肺泡上皮细胞分泌的外泌体调控巨噬细胞极化在急性肺损伤中的作用

doi:10.11843/j.issn.0366-6964.2024.01.008

摘要/Abstract

摘要： 外泌体作为细胞间微环境中的信使，能够将信号在细胞之间进行传递。肺泡上皮细胞通过分泌外泌体来调节机体固有免疫反应。在特定的刺激条件下，肺泡上皮细胞分泌的外泌体通过传递不同效应活性物质，靶向调节巨噬细胞极化通路中的基因表达，参与控制肺部炎症反应的巨噬细胞极化调节。本篇综述主要阐述肺泡上皮细胞源性外泌体，通过靶向调节巨噬细胞极化，调控急性肺损伤（acute lung injury，ALI）作用的最新研究进展，为相关研究提供参考。

关键词: 脓毒症, 急性肺损伤, 肺泡上皮细胞, 巨噬细胞, 外泌体

Abstract: As messengers in the intercellular microenvironment, exosomes can mediate the transmission of signals between cells. Alveolar epithelial cells can regulate the body’s innate immune response in the form of exosomes. Under specific stimulation conditions, exosomes derived from alveolar epithelial cells target and regulate the gene expression pathway by delivering different effector active substances, and participate in the regulation of macrophage polarization, thereby controlling the pulmonary inflammatory response. This article reviews the latest research progress of alveolar epithelial cell-derived exosomes in regulating acute lung injury(ALI)by targeting macrophage polarization, provide reference for related research.

Key words: sepsis, acute lung injury, alveolar epithelial cells, alveolar macrophages, exosomes

中图分类号:

S856.3

王鑫鑫, 林树梅, 赵冬冬, 王学生. 肺泡上皮细胞分泌的外泌体调控巨噬细胞极化在急性肺损伤中的作用[J]. 畜牧兽医学报, 2024, 55(1): 71-78.

WANG Xinxin, LIN Shumei, ZHAO Dongdong, WANG Xuesheng. Role of Exosomes Secreted by Alveolar Epithelial Cells in Regulating Macrophage Polarization in Acute Lung Injury[J]. Acta Veterinaria et Zootechnica Sinica, 2024, 55(1): 71-78.

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