牛病毒性腹泻病毒蛋白的免疫学特性以及相关疫苗研究进展

doi:10.11843/j.issn.0366-6964.2023.04.004

畜牧兽医学报 ›› 2023, Vol. 54 ›› Issue (4): 1381-1391.doi: 10.11843/j.issn.0366-6964.2023.04.004

牛病毒性腹泻病毒蛋白的免疫学特性以及相关疫苗研究进展

李易聪^1,2,3, 蒲飞洋^1,2,3, 冯茜莉^1,2,3, 汪梦竹^1,2,3, 赵泽阳^1,2,3, 张德荣^1,2, 马忠仁^1,2, 周建华^1,2,4*

1. 西北民族大学生物医学研究中心生物工程与技术国家民委重点实验室, 兰州 730030;
2. 西北民族大学生物医学研究中心甘肃省动物细胞技术创新中心, 兰州 730030;
3. 西北民族大学生命科学与工程学院, 兰州 730010;
4. 中国农业科学院兰州兽医研究所, 兰州 730046

收稿日期:2022-04-26 出版日期:2023-04-23 发布日期:2023-04-27
通讯作者: 周建华,主要从事病毒基因工程研究,E-mail:zhoujianhuazjh@163.com
作者简介:李易聪(1998-),女,山西霍州人,硕士生,主要从事病毒基因工程研究,E-mail:lyicongcong@163.com
基金资助:
优秀青年团队培育项目（31920220069）；西北民族大学引进人才科研项目（xbmuyjrc202225）；国家自然科学基金（31302100）

Research Progress on Immunological Characteristics of Bovine Viral Diarrhea Virus Protein and Vaccines

LI Yicong^1,2,3, PU Feiyang^1,2,3, FENG Xili^1,2,3, WANG Mengzhu^1,2,3, ZHAO Zeyang^1,2,3, ZHANG Derong^1,2, MA Zhongren^1,2, ZHOU Jianhua^1,2,4*

1. Key Laboratory of Biotechnology and Bioengineering of State Ethnic Affairs Commission, Biomedical Research Center, Northwest Minzu University, Lanzhou 730030, China;
2. Gansu Tech Innovation Center of Animal Cell, Biomedical Research Center, Northwest Minzu University, Lanzhou 730030, China;
3. College of Life Science and Engineering, Northwest Minzu University, Lanzhou 730010, China;
4. Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China

Received:2022-04-26 Online:2023-04-23 Published:2023-04-27

摘要/Abstract

摘要： 牛病毒性腹泻病毒（bovine viral diarrhea virus，BVDV）众多基因亚型毒株的流行及其宿主谱的扩大干扰着BVDV防控工作。欧洲国家采用全面检测和扑杀BVDV阳性牛的方法达到一定防控效果，但结合我国实际生产情况，使用疫苗防控BVDV仍是最优策略。深入了解病毒感染过程中BVDV蛋白与宿主免疫系统之间的“博弈”，将有助于研究人员在疫苗研发过程中有效规避抗原候选蛋白可能对免疫效果造成的干扰。此外，大力开发低成本、高效力的新型疫苗（如表位肽疫苗和病毒样颗粒疫苗）可以在整合病毒免疫优势抗原表位的基础上加强BVDV相关疫苗的生物安全性，满足用疫苗防控BVDV的要求。鉴于此，本文对BVDV蛋白免疫学功能与特性的研究以及BVDV疫苗开发的现状进行综述，以期为BVDV疫苗研发以及BVDV防控提供一些理论指导。

关键词: 牛病毒性腹泻病毒(BVDV), BVDV蛋白, 疫苗, 免疫

Abstract: The prevalence of numerous genetic subtypes strains of bovine viral diarrhea virus (BVDV) and the expansion of its host spectrum interfere with the prevention and control of BVDV. European countries have adopted the measure of comprehensive detection and culling of BVDV-positive cattle and achieved a certain prevention and control effect, but considering the actual production situation in China, vaccination is still the optimal strategy. An in-depth understanding of the ‘game’ between BVDV proteins and the host immune system during virus infection will help researchers to effectively avoid the potential interference of antigen candidate proteins on immune effects in the term of vaccine development. In addition, vigorously developing low-cost, high-efficiency new-type vaccines (such as epitope peptide vaccine and virus-like particle vaccine) can enhance the biosafety of BVDV vaccines based on integrating viral immunodominant antigenic epitopes, and meet the requirements for the prevention and control of BVDV with vaccines. Thus, in order to provide proof-of-concept towards the development of BVDV vaccine and BVDV prevention and control, this paper reviews the researches on the immunological function and characteristics of BVDV proteins and the current situation of BVDV vaccine development.

Key words: bovine viral diarrhea virus (BVDV), BVDV proteins, vaccines, immunity

中图分类号:

S852.653

李易聪, 蒲飞洋, 冯茜莉, 汪梦竹, 赵泽阳, 张德荣, 马忠仁, 周建华. 牛病毒性腹泻病毒蛋白的免疫学特性以及相关疫苗研究进展[J]. 畜牧兽医学报, 2023, 54(4): 1381-1391.

LI Yicong, PU Feiyang, FENG Xili, WANG Mengzhu, ZHAO Zeyang, ZHANG Derong, MA Zhongren, ZHOU Jianhua. Research Progress on Immunological Characteristics of Bovine Viral Diarrhea Virus Protein and Vaccines[J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(4): 1381-1391.

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牛病毒性腹泻病毒蛋白的免疫学特性以及相关疫苗研究进展

Research Progress on Immunological Characteristics of Bovine Viral Diarrhea Virus Protein and Vaccines

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