毒素-抗毒素系统在细菌生物被膜形成中的作用及调控机制

doi:10.11843/j.issn.0366-6964.2022.10.006

摘要/Abstract

摘要： 毒素-抗毒素（toxin-antitoxin，T-A）系统广泛存在于细菌基因组和质粒中，调控细菌的多种生理活动。细菌生物被膜是细菌适应应激环境（不利环境）而采取的一种生存策略，其具有极强的耐药性及免疫逃逸性，广泛存在于自然界，具有广泛的危害性，严重威胁畜禽和人类的健康。本文对不同类型的T-A系统在细菌生物被膜形成中的作用和分子机制进行综述，旨在为更好地了解和掌握细菌T-A系统在生物被膜形成中的作用和调控关系，为生物被膜的清除和控制奠定基础。

关键词: 生物被膜, 毒素-抗毒素系统, 细菌

Abstract: Toxin-antitoxin (T-A) system exists widely in bacterial genomes and plasmids, and regulates various physiological activities in bacteria. Bacterial biofilm formation is a survival strategy adopted by bacteria to adapt to stressful environments (adverse environments), which has strong antibiotic resistance and immune escape, and widely exists in nature. Biofilms have extensive harm and seriously threatens to the health of livestock, poultry and human. In this review, the roles and regulatory mechanisms of different types of T-A system in biofilm formation were summarized, aiming to better understand and master the roles and regulatory mechanisms of T-A system in biofilm formation, and lay a foundation for the removal and control of biofilm formation.

Key words: biofilm, toxin-antitoxin (T-A) system, bacteria

中图分类号:

S852.61

侯博, 王晨燕, 周伦江. 毒素-抗毒素系统在细菌生物被膜形成中的作用及调控机制[J]. 畜牧兽医学报, 2022, 53(10): 3326-3334.

HOU Bo,WANG Chenyan,ZHOU Lunjiang. The Roles and Regulatory Mechanisms of Toxin-antitoxin System in Bacterial Biofilm Formation[J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53(10): 3326-3334.

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