外源性硫化氢的毒性机制及在动物体内代谢的研究进展

doi:10.11843/j.issn.0366-6964.2021.05.003

摘要/Abstract

摘要： 外源性硫化氢是畜禽养殖过程中由含硫有机物发酵而产生的一种恶臭气体，其具有神经毒性，能刺激眼和呼吸器官，使氧化型细胞色素酶失去活性，并有直接抑制呼吸中枢等作用，引起急性和慢性中毒，高浓度可导致迅速窒息死亡，严重影响畜禽生产、动物福利和人类健康。然而，硫化氢中毒的预防和治疗至今仍缺乏有效的方法，因此，深入研究外源性硫化氢在动物体内的吸收代谢规律，阐明其作用机制，对缓解硫化氢在畜禽生产中的危害具有重要意义。本文从外源性硫化氢的性质及毒性机制、外源性硫化氢对动物机体的危害、外源性硫化氢进入动物体内的途径和分布状况及新陈代谢规律4个方面进行综述，以期为外源性硫化氢对畜禽健康影响机制研究提供参考，为动物健康养殖提供理论依据。

关键词: 硫化氢, 动物, 毒性, 危害, 吸收, 代谢

Abstract: Exogenous hydrogen sulfide (H₂S), a malodorous gas, is released during decomposition of sulfur-containing organic matter in livestock and poultry production. Long-term exposure to H₂S damages central nervous system, irritates eye and respiratory organs, inhibits cytochrome oxidase activity, and even directly depresses the respiratory center, which causes acute and chronic poisoning. Moreover, high concentrations of hydrogen sulfide can quickly lead to asphyxia and death in human and animals. Thus, H₂S seriously affect the livestock and poultry production, animal welfare and human health. However, little is known about the prevention and treatment of hydrogen sulfide poisoning. Therefore, in-depth study of the absorption and metabolism of exogenous hydrogen sulfide in animals and clarification of its mechanism are of great significance to alleviate the harm of hydrogen sulfide in livestock and poultry production. This paper reviews the current research on the characteristics, absorption, metabolism and toxicity of H₂S for the purpose of proving a reference for further research on the mechanism by which H₂S affects animal health and a theoretical foundation for animal healthy breeding.

Key words: hydrogen sulfide, animal, toxicity, harm, absorption, metabolism

中图分类号:

S852.2

谢彦娇, 刘真, 陈磊, 苗启翔, 张宏福, 唐湘方. 外源性硫化氢的毒性机制及在动物体内代谢的研究进展[J]. 畜牧兽医学报, 2021, 52(5): 1163-1170.

XIE Yanjiao, LIU Zhen, CHEN Lei, MIAO Qixiang, ZHANG Hongfu, TANG Xiangfang. Research Progress on Toxicity Mechanism and Metabolism of Exogenous Hydrogen Sulfide[J]. Acta Veterinaria et Zootechnica Sinica, 2021, 52(5): 1163-1170.

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