镉致肝损伤机制及硒拮抗镉肝毒性的研究进展

doi:10.11843/j.issn.0366-6964.2024.04.011

畜牧兽医学报 ›› 2024, Vol. 55 ›› Issue (4): 1456-1466.doi: 10.11843/j.issn.0366-6964.2024.04.011

镉致肝损伤机制及硒拮抗镉肝毒性的研究进展

罗通旺, 吴亚, 王书杰, 宋厚辉*, 邵春艳*

浙江农林大学动物科技学院·动物医学院浙江省畜禽绿色生态健康养殖应用技术研究重点实验室动物健康互联网检测技术浙江省工程实验室动物医学与健康管理浙江省国际科技合作基地中澳动物健康大数据分析联合实验室, 杭州 311300

收稿日期:2023-07-18 出版日期:2024-04-23 发布日期:2024-04-26
通讯作者: 宋厚辉,主要从事人兽共患病流行病学和功能基因组学研究,E-mail:songhh@zafu.edu.cn;邵春艳,主要从事动物中毒病与营养代谢病研究,E-mail:shaocy@zafu.edu.cn
作者简介:罗通旺(1989-)，男，浙江杭州人，讲师，博士，主要从事动物中毒病与营养代谢病研究，E-mail:luotongwang@zafu.edu.cn
基金资助:
浙江农林大学科研发展基金人才启动基金资助项目(2020FR045)；浙江省大学生科技创新活动计划暨新苗人才计划资助项目(2023R412021)

Research Progress on the Mechanism of Cadmium Induced Liver Damage and Selenium Antagonizing Cadmium Hepatotoxicity

LUO Tongwang, WU Ya, WANG Shujie, SONG Houhui*, SHAO Chunyan*

China-Australia Joint Laboratory for Animal Health Big Data Analytics, Zhejiang International Science and Technology Cooperation Base for Veterinary Medicine and Health Management, Zhejiang Provincial Engineering Laboratory for Animal Health Inspection & Internet Technology, Key Laboratory of Applied Technology on Green-Eco-Healthy Animal Husbandry of Zhejiang Province, College of Animal Science and Technology & College of Veterinary Medicine of Zhejiang A&F University, Hangzhou 311300, China

Received:2023-07-18 Online:2024-04-23 Published:2024-04-26

摘要/Abstract

摘要： 镉是一种有毒重金属，能通过食物链蓄积于机体内，造成急性或慢性中毒，严重威胁人类和畜禽的健康。肝是镉毒性损伤的主要靶器官，揭示镉的肝毒性机制以及如何抑制其毒性作用具有重要意义。硒是人体必需的微量元素之一，在维持机体正常生命活动中具有重要作用，近年来，很多研究表明硒能够拮抗镉的肝毒性。本文主要对镉致肝毒性损伤机制以及硒拮抗镉肝毒性的相关研究报道进行归纳总结，以期为镉污染的防治以及硒的临床应用提供参考。

关键词: 镉, 肝毒性, 硒, 作用机制

Abstract: Cadmium is a toxic heavy metal that can accumulate in the body through the food chain, causing acute or chronic poisoning and posing a serious threat to the health of humans and livestock. Liver is the main target organ of cadmium toxicity injury. Therefore, it is of great significance to reveal the mechanism of cadmium hepatotoxicity and how to inhibit its toxic effect. Selenium is one of the essential trace elements in the human body and plays an important role in maintaining normal life activities. In recent years, many studies have shown that selenium has the effect of antagonizing cadmium hepatotoxicity. This article mainly summarizes the related studies on the mechanism of cadmium induced hepatotoxicity and the antagonism of selenium, hoping to provide reference for the prevention and treatment of cadmium pollution as well as the clinical application of selenium.

Key words: cadmium, hepatotoxicity, selenium, mechanism

中图分类号:

S856.5

罗通旺, 吴亚, 王书杰, 宋厚辉, 邵春艳. 镉致肝损伤机制及硒拮抗镉肝毒性的研究进展[J]. 畜牧兽医学报, 2024, 55(4): 1456-1466.

LUO Tongwang, WU Ya, WANG Shujie, SONG Houhui, SHAO Chunyan. Research Progress on the Mechanism of Cadmium Induced Liver Damage and Selenium Antagonizing Cadmium Hepatotoxicity[J]. Acta Veterinaria et Zootechnica Sinica, 2024, 55(4): 1456-1466.

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镉致肝损伤机制及硒拮抗镉肝毒性的研究进展

Research Progress on the Mechanism of Cadmium Induced Liver Damage and Selenium Antagonizing Cadmium Hepatotoxicity

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