阿法沙龙与异氟烷静吸复合麻醉对犬麻醉效果的影响

doi:10.11843/j.issn.0366-6964.2021.04.027

摘要/Abstract

摘要： 旨在探讨使用不同剂量阿法沙龙和异氟烷静吸复合麻醉（IVIA）对犬麻醉效果的比较。对18只试验犬随机编号后分为L（1～6号）、M（7～12号）、H（13～18号）3组，分别使用阿法沙龙3、6、9 mg·（kg·h）^-1静脉恒速滴注（CRI）配合0.5%异氟烷的维持麻醉方案，观察并记录诱导麻醉前1 h（T0）、维持麻醉期间（15、30、45、60 min）及停止给药后15 min（75 min）时，犬的生理指标、镇痛、镇静及肌松效果。45 d后，对该18只试验犬按原编号分组为CⅠ（1～6号）、CⅡ（7～12号）、CⅢ（13～18号）进行吸入性维持麻醉（2%异氟烷），同样记录各指标。两轮试验均使用丙泊酚进行诱导麻醉。结果显示：L组与CⅠ组比较发现，在各时间点生理指标基本无统计学差异（P>0.05），但L组存在轻度疼痛反应；与M组比较，CⅡ组体温、血氧均明显下降（P<0.05），CⅡ组脉搏、心率、呼吸频率、舒张压显著下降，差异极显著（P<0.01），麻醉中两组（M及CⅡ组）均无疼痛反应；与H组比较，CⅢ组脉搏、心率存在统计学差异（P<0.05），麻醉中两组（H及CⅢ组）均无疼痛反应。IVIA和单纯吸入麻醉均可获得较好的麻醉效果，但阿法沙龙剂量为6 mg·（kg·h）^-1的IVIA可提高试验犬的心率、脉搏，对心血管和体温影响较小，同时无疼痛反应、麻醉深度良好及苏醒迅速。相较于常规呼吸麻醉，该麻醉方案可提高犬的整体麻醉质量。

关键词: 静吸复合麻醉, 阿法沙龙, 异氟烷, 麻醉效果, 犬

Abstract: In this study, we compared the anesthetic effect of intravenous-inhalation anesthesia(IVIA) of different doses of alfaxalone combined with isoflurane in dogs. Eighteen experimental dogs were randomly numbered and divided into three groups: L (No.1-6), M (No.7-12) and H (No.13-18). Alfaxalone 3, 6, 9 mg·(kg·h)^-1 intravenous constant rate infusion (CRI) combined with 0.5% isoflurane inhalation was used, for maintenance anesthesia, respectively. The physiological indexes, analgesia, sedation and muscle relaxant effect of dogs were observed and recorded at 1 h (T0) before induction anesthesia, 15 min, 30 min, 45 min, and 60 min during maintenance anesthesia, and 15 min (75 min) after the anesthesia. After 45 days, the 18 dogs were grouped according to their original numbers: CⅠ (No.1-6), CⅡ (No.7-12) and CⅢ (No.13-18) for inhalation maintenance anesthesia (2% isoflurane), all data is also recorded. Propofol was used for induction anesthesia in both rounds. There was no statistically significant difference in physiological indexes between group L and group CⅠ(P>0.05)，however, group L had mild pain reaction；Compared with group M, the temperature and blood oxygen of animals in group CⅡ decreased significantly(P>0.05) and pulse, heart rate, respiratory rate and diastolic blood pressure in group CⅡ significantly decreased (P<0.01). There was no pain response in both groups (M and CⅡ group) during anesthesia. Compared with group H, There were statistical differences in pulse and heart rate in group CⅢ (P<0.05), no pain reaction was observed in both groups (H and CⅢ group) during anesthesia. Both intravenous-inhalation anesthesia and simple inhalation anesthesia can get better anesthesia effect, of which alfaxalone dose of 6 mg/(kg·h)^-1 of IVIA can improve the experimental dogs heart rate and pulse, it has little effect on cardiovascular and temperature, at the same time without pain reaction, good depth of anesthesia and wake up fast, compared with the conventional respiratory simple inhalation anesthesia, this anesthetic scheme can improve the overall anesthesia quality of dogs.

Key words: intravenous-inhalation anesthesia, alfaxalone, isoflurane, anesthestic effect of anesthesi, dogs

中图分类号:

S859.791

戴超英, 林强锋, 吴梦伊, 胡崇伟. 阿法沙龙与异氟烷静吸复合麻醉对犬麻醉效果的影响[J]. 畜牧兽医学报, 2021, 52(4): 1115-1125.

DAI Chaoying, LIN Qiangfeng, WU Mengyi, HU Chongwei. Influence of Intravenous-inhalation Anesthesia of Alfaxalone Combined with Isoflurane on Anesthetic Effects in Dogs[J]. Acta Veterinaria et Zootechnica Sinica, 2021, 52(4): 1115-1125.

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