生物节律对动物生理营养及物质消化利用调控的研究进展

doi:10.11843/j.issn.0366-6964.2021.04.003

摘要/Abstract

摘要： 生物钟是生物的计时机制，是生物体内的一种无形的“时钟”。实际上是生物体生命活动的内在节律性，是由生物体内的时间结构序列所决定，使行为、生理和新陈代谢的内部循环与外界环境周期性同步。本文就生物节律系统、生物钟的调控基因、生物钟对营养生理代谢和消化器官的调控以及其在实际生产中的应用作一综述。

关键词: 生物节律, 生物钟, 营养代谢, 营养调控

Abstract: Circadian clock is timing mechanism, it is an invisible “clock” in the organism, and it is actually an organism inner rhythm of life activity. It is determined by the time sequence structure in the organism. It keeps the periodicity in the internal circulation of behavior, physiology and metabolism, and in sync with the external environment. In this paper, the circadian system, the regulation genes of circadian clock, the regulation of biological clock on nutrient metabolism and digestive organs, and its application in practical production are reviewed.

Key words: biological rhythm, circadian clock, nutrition metabolism, nutritional regulation

中图分类号:

S852.21

张春桃, 马涛, 屠焰, 刁其玉. 生物节律对动物生理营养及物质消化利用调控的研究进展[J]. 畜牧兽医学报, 2021, 52(4): 872-880.

ZHANG Chuntao, MA Tao, TU Yan, DIAO Qiyu. The Relationship between Biorhythms and Physiological Nutrients and Substance Digestion and Utilization in Animals[J]. Acta Veterinaria et Zootechnica Sinica, 2021, 52(4): 872-880.

参考文献 41

[1]	MASRI S, SASSONE-CORSI P. The emerging link between cancer, metabolism, and circadian rhythms[J]. Nat Med, 2018, 24(12):1795-1803.
[2]	MAURY E. Off the clock:From circadian disruption to metabolic disease[J]. Int J Mol Sci, 2019, 20(7):1597.
[3]	HONMA S. The mammalian circadian system:a hierarchical multi-oscillator structure for generating circadian rhythm[J]. J Physiol Sci, 2018, 68(3):207-219.
[4]	YU Q. Biological clock:the oscillator of gene expression[J]. Sci China Life Sci, 2018, 61(1):128-130.
[5]	THAISS C A, ZEEVI D, LEVY M, et al. Transkingdom control of microbiota diurnal oscillations promotes metabolic homeostasis[J]. Cell, 2014, 159(3):514-529.
[6]	BASS J. Circadian topology of metabolism[J]. Nature, 2012, 491(7424):348-356.
[7]	MOHAWK J A, GREEN C B, TAKAHASHI J S. Central and peripheral circadian clocks in mammals[J]. Annu Rev Neurosci, 2012, 35(1):445-462.
[8]	MARCHEVA B, RAMSEY K M, BUHR E D, et al. Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes[J]. Nature, 2010, 466(7306):627-631.
[9]	SOLT L A, WANG Y J, BANERJEE S, et al. Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists[J]. Nature, 2012, 485(7396):62-68.
[10]	JHA P K, CHALLET E, KALSBEEK A. Circadian rhythms in glucose and lipid metabolism in nocturnal and diurnal mammals[J]. Mol Cell Endocrinol, 2015, 418:74-88.
[11]	WU X, GUO X Y, XIE C Y, et al. Effects of a two-meal daily feeding pattern with varied crude protein levels on growth performance and antioxidant indexes in pigs[J]. Anim Nutr, 2016, 2(4):267-270.
[12]	MORRIS C J, YANG J N, GARCIA J I, et al. Endogenous circadian system and circadian misalignment impact glucose tolerance via separate mechanisms in humans[J]. Proc Natl Acad Sci U S A, 2015, 112(17):E2225-E2234.
[13]	MASON I C, QIAN J Y, ADLER G K, et al. Impact of circadian disruption on glucose metabolism:implications for type 2 diabetes[J]. Diabetologia, 2020, 63(3):462-472.
[14]	GAO L M, XIE C Y, ZHANG T Y, et al. Maternal supplementation with calcium varying with feeding time daily during late pregnancy affects lipid metabolism and transport of placenta in pigs[J]. Biochem Biophys Res Commun, 2018, 505(2):624-630.
[15]	BELL A W. Regulation of organic nutrient metabolism during transition from late pregnancy to early lactation[J]. J Anim Sci, 1995, 73(9):2804-2819.
[16]	DIBNER C, SCHIBLER U, ALBRECHT U. The mammalian circadian timing system:organization and coordination of central and peripheral clocks[J]. Annu Rev Physiol, 2010, 72:517-549.
[17]	GORDON J G, MCALLISTER I K. The circadian rhythm of rumination[J]. J Agric Sci, 1970, 74(2):291-297.
[18]	WU X, XIE C Y, LONG C M, et al. Effects of a daily 3-meal pattern with different dietary protein contents on pig growth performance, carcass and muscle quality traits[J]. J Sci Food Agric, 2018, 98(1):415-421.
[19]	WANG J K, MAUVOISIN D, MARTIN E, et al. Nuclear proteomics uncovers diurnal regulatory landscapes in mouse liver[J]. Cell Metab, 2017, 25(1):102-117.
[20]	PULLEN D L, PALMQUIST D L, EMERY R S. Effect on days of lactation and methionine hydroxy analog on incorporation of plasma fatty acids into plasma triglycerides[J]. J Dairy Sci, 1989, 72(1):49-58.
[21]	REDDY A B, MAYWOOD E S, KARP N A, et al. Glucocorticoid signaling synchronizes the liver circadian transcriptome[J]. Hepatology, 2007, 45(6):1478-1488.
[22]	SHAANI Y, ZEHAVI T, EYAL S, et al. Microbiome niche modification drives diurnal rumen community assembly, overpowering individual variability and diet effects[J]. ISME J, 2018, 12(10):2446-2457.
[23]	CRUZ C, ROCCO P D, HACKWORTH C. Effects of quick rotating shift schedules on the health and adjustment of air traffic controllers[J]. Aviat Space Environ Med, 2000, 71(4):400-407.
[24]	徐巧云. PER2蛋白影响消化道上皮挥发性脂肪酸吸收机制的研究[D]. 扬州:扬州大学, 2019.XU Q Y. Study on the mechanism of PER2 affecting the absorption of volatile fatty acids in the digestive tract[D]. Yangzhou:Yangzhou University, 2019. (in Chinese)
[25]	KHAFIPOUR E, KRAUSE D O, PLAIZIER J C. A grain-based subacute ruminal acidosis challenge causes translocation of lipopolysaccharide and triggers inflammation[J]. J Daily Sci, 2009, 92(3):1060-1070.
[26]	GOO R H, MOORE J G, GREENBERG E, et al. Circadian variation in gastric emptying of meals in humans[J]. Gastroenterology, 1987, 93(3):515-518.
[27]	LINDBERG G, IWARZON M, HAMMARLUND B. 24-hour ambulatory electrogastrography in healthy volunteers[J]. Scand J Gastroenterol, 1996, 31(7):658-664.
[28]	KUMAR D, WINGATE D, RUCKEBUSCH Y. Circadian variation in the propagation velocity of the migrating motor complex[J]. Gastroenterology, 1986, 91(4):926-930.
[29]	BRUININX E M A M, HEETKAMP M J W, VAN DEN BOGAART D, et al. A prolonged photoperiod improves feed intake and energy metabolism of weanling pigs[J]. J Anim Sci, 2002, 80(7):1736-1745.
[30]	MARTELLI G, NANNONI E, GRANDI M, et al. Growth parameters, behavior, and meat and ham quality of heavy pigs subjected to photoperiods of different duration[J]. J Anim Sci, 2015, 93(2):758-766.
[31]	李胜利, 孙海洲, 赵存发, 等. 控制光照对内蒙古白绒山羊母羊营养物质消化率的影响研究[J]. 家畜生态学报, 2014, 35(9):28-32.LI S L, SUN H Z, ZHAO C F, et al. Effects of photoperiod on nutrient digestibility of Inner Mongolia white cashmere goat[J]. Acta Ecologae Animalis Domastici, 2014, 35(9):28-32. (in Chinese)
[32]	LACASSE P, VINET C M, PEITTCLERC D. Effect of prepartum photoperiod and melatonin feeding on milk production and prolactin concentration in dairy heifers and cows[J]. J Dairy Sci, 2014, 97(6):3589-3598.
[33]	李玉鹏, 陈丽丽, 李海花, 等. 饲粮蛋白质水平日变化对育肥猪生长性能和血液生化指标的影响[J]. 中国饲料, 2019(15):76-79.LI Y P, CHEN L L, LI H H, et al. Effects of dynamic diets with different CP levels on growth performance and biochemistry indexes of growing pigs[J]. China Feed, 2019(15):76-79. (in Chinese)
[34]	NIEKAMP S R, SUTHERLAND M A, DAHL G E, et al. Photoperiod influences the immune status of multiparous pregnant sows and their piglets[J]. J Anim Sci, 2006, 84(8):2072-2082.
[35]	TAO Z, SONG W, ZHU C, et al. Comparative transcriptomic analysis of high and low egg-producing duck ovaries[J]. Poult Sci, 2017, 96(12):4378-4388.
[36]	王晓娟, 刘磊, 焦洪超, 等. 生物钟在蛋鸡排卵-产蛋过程中的调控作用[J]. 中国农业科学, 2018, 51(16):3181-3190.WANG X J, LIU L, JIAO H C, et al. Regulation of biological clock in ovulation-laying of laying hens[J]. Scientia Agricultura Sinica, 2018, 51(16):3181-3190. (in Chinese)
[37]	ZHANG L, ZHANG H J, WANG J, et al. Stimulation with monochromatic green light during incubation alters satellite cell mitotic activity and gene expression in relation to embryonic and posthatch muscle growth of broiler chickens[J]. Animal, 2014, 8(1):86-93.
[38]	WANG M, ZHOU Z, KHAN M J, et al. Clock circadian regulator (CLOCK) gene network expression patterns in bovine adipose, liver, and mammary gland at 3 time points during the transition from pregnancy into lactation[J]. J Dairy Sci, 2015, 98(7):4601-4612.
[39]	ZHANG C Z, SUN H Z, LI S L, et al. Effects of photoperiod on nutrient digestibility, hair follicle activity and cashmere quality in Inner Mongolia white cashmere goats[J]. Asian-Australas J Anim Sci, 2019, 32(4):541-547.
[40]	IWANAGA H, YANO M, MIKI H, et al. Per2 gene expressions in the suprachiasmatic nucleus and liver differentially respond to nutrition factors in rats[J]. J Parenter Enteral Nutr, 2005, 29(3):157-161.
[41]	THAISS C A, LEVY M, KOREM T, et al. Microbiota diurnal rhythmicity programs host transcriptome oscillations[J]. Cell, 2016, 167(6):1495-1510.