长链非编码RNA——病毒与宿主相互作用中的新型调控因子

doi:10.11843/j.issn.0366-6964.2020.09.003

摘要/Abstract

摘要： 长链非编码RNA（long non-coding RNAs，lncRNAs）是一类长度>200 nt的非编码RNA，在多种生物学过程中发挥重要调控作用。近年来研究表明，lncRNAs可被病毒诱导表达，其作为一类新型的调控因子介导宿主与病毒相互作用，通过病原识别受体，以不同机制激活或抑制天然免疫应答反馈病毒感染。本文阐述了lncRNAs介导病毒与宿主相互作用中的调控机制，归纳了它们在宿主抗病毒天然免疫应答过程中的调控网络，以期为研究lncRNAs在抗病毒中的作用提供参考，为揭示病毒的致病机制和发现新的抗病毒靶标奠定基础。

关键词: 长链非编码RNA, 病毒, 天然免疫, 病原识别受体

Abstract: Long non-coding RNAs (lncRNAs) are designated as the transcripts longer than 200 nt without protein-coding capacity, which play a crucial role in various biological processes. Current evidence demonstrates that lncRNAs, an important class of novel regulatory RNAs, are induced by viruses and mediate host-virus interactions. They can regulate pathogen recognition receptors and inhibit or activate natural immune responses to feedback viral infections through different mechanisms. In this paper, we focus on the regulation of lncRNAs in virus-host interactions and highlight the regulatory networks of host antiviral responses. This review provides a valuable reference for studying the antiviral effect and mechanism of lncRNAs, and lays the foundation for revealing the pathogenesis mechanism of the virus and discovering new antiviral targets.

Key words: long noncoding RNA, virus, innate immune, pathogen recognition receptor

中图分类号:

Q522
Q527.5

赵学亮, 刘海金, 萧飒, 王兴龙, 杨增岐. 长链非编码RNA——病毒与宿主相互作用中的新型调控因子[J]. 畜牧兽医学报, 2020, 51(9): 2059-2067.

ZHAO Xueliang, LIU Haijin, XIAO Sa, WANG Xinglong, YANG Zengqi. Long Non-coding RNAs: Novel Regulators of Virus-host Interactions[J]. Acta Veterinaria et Zootechnica Sinica, 2020, 51(9): 2059-2067.

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