mRNA中N6-甲基腺苷修饰及其在动物中的研究进展

doi:10.11843/j.issn.0366-6964.2019.01.001

Abstract

Abstract:

The N⁶-methyladenosine (m⁶A) modification is the most abundant RNA modification in animals, and is dynamically regulated by methyltransferase, demethylase and m⁶A binding protein. In mRNA, m⁶A modification can regulate most RNA metabolism processes and play an important physiological role in animals. In this review, the research progress of distribution and expression, detection methods, enzymes related to methylation metabolism and their physiological functions of m⁶A modification in animals are well introduced. Besides, the existing problems or challenges in the current m⁶A modification research are prospected in the present study, which will provide reference for further study on m⁶A modification.

Key words: N⁶-methyladenosine, RNA epigenetics, distribution and expression, detection method, m⁶A regulator, physiological function

CLC Number:

Q524
Q527

LU Zengkui, ZHANG Liping, LI Qing, LIU Enmin, DU Lixin, CHU Mingxing, WEI Caihong. N⁶-methyladenosine Modification in mRNA and Its Research Advance in Animals[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2019, 50(1): 1-13.

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N⁶-methyladenosine Modification in mRNA and Its Research Advance in Animals

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N6-methyladenosine Modification in mRNA and Its Research Advance in Animals

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N⁶-methyladenosine Modification in mRNA and Its Research Advance in Animals