胍基乙酸及代谢产物肌酸的研究进展

doi:10.11843/j.issn.0366-6964.2018.08.002

Abstract

Abstract:

Guanidinoacetic acid, a white water-soluble amino acid derivative, is a natural precursor of creatine, also known as guanidine acetic acid. At present, guanidinoacetic acid is widely used as a feed additive to increase muscle yield and improve carcass meat quality in animal production. This review summarizes the physiological functions of guanidinoacetic acid, stimulating insulin release, neuromodulation, altering the metabolic utilization of arginine and adjusting the oxidant-antioxidant status, and the function of creatine, a metabolite of guanidinoacetic acid, promoting the differentiation of skeletal muscle and inhibiting differentiation of adipocytes. Which will provide a reference for the follow-up guanidinoacetic acid related research.

CLC Number:

S816

WANG Yu-jie, ZHANG Jin-wei, WANG Xun, LI Ming-zhou, LI Xue-wei, MA Ji-deng. The Research Progress of Guanidinoacetic Acid and Creatine[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2018, 49(8): 1577-1584.

0
/ / Recommend

Add to citation manager EndNote|Reference Manager|ProCite|BibTeX|RefWorks

URL: https://www.xmsyxb.com/EN/10.11843/j.issn.0366-6964.2018.08.002

https://www.xmsyxb.com/EN/Y2018/V49/I8/1577

References

[1] OSTOJIC S M.Guanidinoacetic acid as a performance-enhancing agent[J].Amino Acids,2016,48(8):1867-1875.
[2] BARCELOS R P,STEFANELLO S T,MAURIZ J L,et al.Creatine and the liver:Metabolism and possible interactions[J].Mini Rev Med Chem,2016,16(1):12-18.
[3] WYSS M,KADDURAH-DAOUK R.Creatine and creatinine metabolism[J].Physio Rev,2000,80(3):1107-1213.
[4] WANG L S,SHI B M,SHAN A S,et al.Effects of guanidinoacetic acid on growth performance,meat quality and antioxidation in growing-finishing pigs[J].J Anim Vet Adv,2012,11(5):631-636.
[5] MICHIELS J,MAERTENS L,BUYSE J,et al.Supplementation of guanidinoacetic acid to broiler diets:Effects on performance,carcass characteristics,meat quality,and energy metabolism[J].Poult Sci,2012,91(2):402-412.
[6] EDISON E E,BROSNAN M E,MEYER C,et al.Creatine synthesis:Production of guanidinoacetate by the rat and human kidney in vivo[J].Am J Physiol Renal Physiol,2007,293(6):F1799-F1804.
[7] MCGUIRE D M,GROSS M D,VAN PILSUM J F,et al.Repression of rat kidney L-arginine:Glycine amidinotransferase synthesis by creatine at a pretranslational level[J].J Biol Chem,1984,259(19):12034-12038.
[8] SNOW R J,MURPHY R M.Creatine and the creatine transporter:A review[J].Mol Cell Biochem,2001,224(1-2):169-181.
[9] CURT M J C,VOICU P M,FONTAINE M,et al.Creatine biosynthesis and transport in health and disease[J].Biochimie,2015,119(5):146-165.
[10] OSTOJIC S M,DRID P,OSTOJIC J.Guanidinoacetic acid increases skeletal muscle creatine stores in healthy men[J].Nutrition,2016,32(6):723-724.
[11] MCBREAIRTY L E,ROBINSON J L,FURLONG K R,et al.Guanidinoacetate is more effective than creatine at enhancing tissue creatine stores while consequently limiting methionine availability in Yucatan miniature pigs[J].PLoS One,2015,10(6):1-11.
[12] TACHIKAWA M,KASAI Y,YOKOYAMA R,et al.The blood-brain barrier transport and cerebral distribution of guanidinoacetate in rats:Involvement of creatine and taurine transporters[J].J Neurochem,2009,111(2):499-509.
[13] FAGERBERG L,HALLSTR M B M,OKSVOLD P,et al.Analysis of the human tissue-specific expression by genome-wide integration of transcriptomics and antibody-based proteomics[J].Mol Cell Proteomics,2014,13(2):397-406.
[14] MARCO J,CALLE C,HEDO J A,et al.Glucagon-releasing activity of guanidine compounds in mouse pancreatic islets[J].FEBS Lett,1976,64(1):52-54.
[15] NEU A,NEUHOFF H,TRUBE G,et al.Activation of GABA_A receptors by guanidinoacetate:A novel pathophysiological mechanism[J]. Neurobiol Dis,2002,11(2):298-307.
[16] OSTOJIC S M,STOJANOVIC M.Guanidinoacetic acid loading affects plasma γ-aminobutyric acid in healthy men[J].Eur J Nutr,2015, 54(5):855-858.
[17] DILGER R N,BRYANT-ANGELONI K,PAYNE R L,et al.Dietary guanidino acetic acid is an efficacious replacement for arginine for young chicks[J].Poult Sci,2013,92(1):171-177.
[18] YAZDI F T,GOLIAN A,ZARGHI H,et al.Effect of wheat-soy diet nutrient density and guanidine acetic acid supplementation on performance and energy metabolism in broiler chickens[J].Ital J Anim Sci,2017,16(4):593-600.
[19] HIRAMATSU M.A role for guanidino compounds in the brain[J].Mol Cell Biochem,2003,244(1-2):57-62.
[20] OSTOJIC S M.Advanced physiological roles of guanidinoacetic acid[J].Eur J Nutr,2015,54(8):1211-1215.
[21] TONG B C,BARBUL A.Cellular and physiological effects of arginine[J].Mini Rev Med Chem,2004,4(8):823-832.
[22] MORI A,KOHNO M,MASUMIZU T,et al.Guanidino compounds generate reactive oxygen species[J].IUBMB Life,1996,40(1):135-143.
[23] 代重山,马佳,王泽明,等.胍基乙酸的致突变性研究[J].中国饲料,2017(3):16-19.
DAI Z S,MA J,WANG Z M,et al.The study on mutagenicity of Guanidinoacetic acid[J].China Feed,2017(3):16-19. (in Chinese)
[24] OSTOJIC S M,NIESS B,STOJANOVIC M,et al.Creatine metabolism and safety profiles after six-week oral guanidinoacetic acid administration in healthy humans[J].Int J Med Sci,2013,10(2):141-147.
[25] OSTOJIC S M,STOJANOVIC M,DRID P,et al.Dose-response effects of oral guanidinoacetic acid on serum creatine,homocysteine and B vitamins levels[J].Eur J Nutr,2014,53(8):1637-1643.
[26] MCCULLY K S.Homocysteine and the pathogenesis of atherosclerosis[J].Expert Rev Clin Pharmacol,2015,8(2):211-219.
[27] OSTOJIC S M,NIESS B,STOJANOVIC M,et al.Co-administration of methyl donors along with guanidinoacetic acid reduces the incidence of hyperhomocysteinaemia compared with guanidinoacetic acid administration alone[J].Brit J Nutr,2013,110(5):865-870.
[28] European Food Safety Authority.Safety and efficacy of guanidinoacetic acid as feed additive for chickens for fattening[J].EFSA J,2009,7(3):1-30.
[29] European Food Safety Authority.Safety and efficacy of guanidinoacetic acid for chickens for fattening,breeder hens and roosters,and pigs[J].EFSA J,2016,14(2):1-39.
[30] SESTILI P,BARBIERI E,STOCCHI V.Effects of creatine in skeletal muscle cells and in myoblasts differentiating under normal or oxidatively stressing conditions[J].Mini Rev Med Chem,2015,16(1):4-11.
[31] GERBER I,GWYNN I,ALINI M,et al.Stimulatory effects of creatine on metabolic activity,differentiation and mineralization of primary osteoblast-like cells in monolayer and micromass cell cultures[J].Eur Cells Mater,2005,10:8-22.
[32] NAYEONL,INHEE K,SOOJEONG P,et al.Creatine inhibits adipogenesis by downregulating insulin-induced activation of the phosphatidylinositol 3-kinase signaling pathway[J].Stem Cells Dev,2015,24(8):983-994.
[33] WILLOUGHBY D S,ROSENE J.Effects of oral creatine and resistance training on myosin heavy chain expression[J].Med Sci Sports Exerc,2001,33(10):1674-1681.
[34] WILLOUGHBY D S,ROSENE J R.Effects of oral creatine and heavy resistance training on myogenic regulatory factor and creatine kinase expression[J].Med Sci Sports Exerc,2003,35(6):923-929.
[35] VIERCK J L,ICENOGGLE D L,BUCCI L,et al.The effects of ergogenic compounds on myogenic satellite cells[J].Med Sci Sports Exerc,2003,35(5):769-776.
[36] LOUIS M,VAN BENEDEN R,DEHOUX M,et al.Creatine increases IGF-I and myogenic regulatory factor mRNA in C₂C₁₂ cells[J].FEBS Lett,2004,557(1-3):243-247.
[37] SESTILI P,BARBIERI E,MARTINELLI C,et al.Creatine supplementation prevents the inhibition of myogenic differentiation in oxidatively injured C₂C₁₂ murine myoblasts[J].Mol Nutr Food Res,2009,53(9):1187-1204.
[38] DELDICQUE L,THEISEN D,BERTRAND L,et al.Creatine enhances differentiation of myogenic C₂C₁₂ cells by activating both p38 and Akt/PKB pathways[J].Am J Physiol Cell Physiol,2007,293(4):C1263-C1271.
[39] DELDICQUE L,LOUIS M,NIELENS H,et al.Increased IGF mRNA in human skeletal muscle after creatine supplementation[J].Med Sci Sports Exerc,2005,37(5):731-736.
[40] SAFDAR A,YARDLEY N J,SNOW R,et al.Global and targeted gene expression and protein content in skeletal muscle of young men following short-term creatine monohydrate supplementation[J].Physiol Genomics,2008,32(2):219-228.
[41] BURKE D G,CANDOW D G,CHILIBECK P D,et al.Effect of creatine supplementation and resistance-exercise training on muscle insulin-like growth factor in young adults[J].Int J Sports Nutr Exerc Metab,2008,18(4):389-398.
[42] HANSEN J M,KLASS M,HARRIS C,et al.A reducing redox environment promotes C₂C₁₂ myogenesis:Implications for regeneration in aged muscle[J].Cell Biol Int,2007,31(6):546-553.
[43] ZACCAGNINI G,MARTELLI F,MAGENTA A,et al.p66^ShcA and oxidative stress modulate myogenic differentiation and skeletal muscle regeneration after hind limb ischemia[J].J Biol Chem,2007,282(43):31453-31459.
[44] ARDITE E,BARBERA J A,ROCA J,et al.Glutathione depletion impairs myogenic differentiation of murine skeletal muscle C₂C₁₂ cells through sustained NF-κB activation[J].Am J Pathol,2004,165(3):719-728.
[45] LANGEN R C J,SCHOLS A M W J,KELDERS M C J M,et al.Tumor necrosis factor-αinhibits myogenesis through redox-dependent and -independent pathways[J].Am J Physiol Cell Physiol,2002,283(3):C714-C721.
[46] BARBIERI E,GUESCINI M,CALCABRINI C,et al.Creatine prevents the structural and functional damage to mitochondria in myogenic,oxidatively stressed C₂C₁₂ cells and restores their differentiation capacity[J].Oxid Med Cell Longev,2016,2016:1-12.
[47] MORENO-NAVARRETE J M,FERNÁNDEZ-REAL J M.Adipocyte Differentiation[M].New York,NY:Springer,2012:17-38.
[48] HALL K D,HEYMSFIELD S B,KEMNITZ J W,et al.Energy balance and its components:Implications for body weight regulation[J].Am J Clin Nutr,2012,95(4):989-994.
[49] KAZAK L,CHOUCHANI E T,LU G Z,et al.Genetic depletion of adipocyte creatine metabolism inhibits diet-induced thermogenesis and drives obesity[J].Cell Metab,2017,26(4):600-671.
[50] LIM K,PULLALAREVU S,SURABIAN K T,et al.Structural basis for the mechanism and substrate specificity of glycocyamine kinase,a phosphagen kinase family member[J].Biochemistry,2010,49(9):2031-2041.
[51] KAN H E,JAN RENEMA W K,ISBRANDT D,et al.Phosphorylated guanidinoacetate partly compensates for the lack of phosphocreatine in skeletal muscle of mice lacking guanidinoacetate methyltransferase[J].J Physiol,2004,560(1):219-229.
[52] LYGATE C A,AKSENTIJEVIC D,DAWSON D,et al.Living without creatine:Unchanged exercise capacity and response to chronic myocardial infarction in creatine-deficient mice[J].Circ Res,2013,112(6):945-955.
[53] 刘洋,李蛟龙,张林,等.胍基乙酸和甜菜碱对育肥猪肌肉能量代谢和肉品质的影响[J].畜牧兽医学报,2015,49(9):1557-1563.
LIU Y,LI J L,ZHANG L,et al.Effects of dietary supplementation of guanidinoacetic acid and combination of guanidinoacetic acid and betaine on muscle energy metabolism,meat quality in finishing pigs[J].Acta Veterinaria et Zootechnica Sinica,2015,49(9):1557-1563. (in Chinese)
[54] 韩剑众,顾振宇,吴劲松,等.一水肌酸对肥育猪胴体组成和肉质的影响及机理研究[J].中国粮油学报,2007,22(3):101-106.
HAN J Z,GU Z Y,WU J S,et al.Effects and mechanism:Creatine monohydrate on carcass characteristics and meat quality of finishing swine[J].Journal of the Chinese Cereals and Oils Association,2007,22(3):101-106. (in Chinese)
[55] STEAD L M,AU K P,JACOBS R L,et al.Methylation demand and homocysteine metabolism:Effects of dietary provision of creatine and guanidinoacetate[J].Am J Physiol Endocrinol Metab,2001,281(5):E1095-E1100.
[56] STEAD L M,BROSNAN J T,BROSNAN M E,et al.Is it time to reevaluate methyl balance in humans?[J].Am J Clin Nutr,2006,83(1):5-10.
[57] OHUCHI S,MATSUMOTO Y,MORITA T,et al.High-casein diet suppresses guanidinoacetic acid-induced hyperhomocysteinemia and potentiates the hypohomocysteinemic effect of serine in rats[J].Biosci Biotechnol Biochem,2008,72(12):3258-3264.
[58] SETOUE M,OHUCHI S,MORITA T,et al.Hyperhomocysteinemia induced by guanidinoacetic acid is effectively suppressed by choline and betaine in rats[J].Biosci Biotechnol Biochem,2008,72(7):1696-1703.

The Research Progress of Guanidinoacetic Acid and Creatine

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	XIA Chunqiu, WAN Fachun, LIU Lei, SHEN Weijun, XIAO Dingfu. Valine: Biological Function and Application in Livestock and Poultry Diets [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(11): 4502-4513.
[2]	REN Hongyang, ZHENG Linfeng, WANG Zili, WANG Hongliang. Effects of Mixing Materials on Crude Protein Content and Fermentation Quality of Whole Corn Silage [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(11): 4526-4536.
[3]	WU Zhili, YAO Junhu, LEI Xinjian. Research Progress of Rumen-protected Glucose on Nutritional Regulation in Perinatal Dairy Animals [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(8): 3173-3182.
[4]	LIU Jinmei, CHANG Wenhuan, CHEN Zhimin, ZHENG Aijuan, QIU Kai, WANG Zedong, LIU Guohua, CAI Huiyi. Research Progress of Pectin and Its Microbial Degradation [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(7): 2723-2731.
[5]	ZHAO Wei, Mahmoud M. Abdelsattar, CHAI Jianmin, WANG Xin, DIAO Qiyu, ZHANG Naifeng. Research Progress of Rumen Microbiota Transplantation and Its Application [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(5): 1792-1803.
[6]	SUN Yufan, YU Panyuan, CHEN Hongyu, TAN Yiqing, CHEN Xiabing, ZHANG Tengfei, GAO Ting, ZHOU Rui, LI Lu. Evaluation of the Efficacy of Potassium Diformate in the Prevention of Salmonella Infection and the Effect on Intestinal Flora [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(5): 2101-2113.
[7]	YANG Zihui, DONG Zhen, WU Huilan, TAN Bin, ZENG Jianguo. Analysis of the Material Basis and Mechanism of Action of Antioxidant Function of Taraxacum mongolicum based on Network Pharmacology [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(5): 2170-2185.
[8]	ZHUO Ruhao, LIU Qingyang, ZHONG Xiang. Advances in the Roles of Curcumin on Regulating Gut Microbiota and Antiviral Effects [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(2): 473-483.
[9]	ZHAO Yaya, CHANG Jiang, JU Ning, LUO Yulong. Mechanism of Plant Polyphenols Addition in Diet Regulating Meat Color Stability [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(1): 36-47.
[10]	LI Kai, ZHAO Yuqing, ZHONG Ruqing, LIU Lei, YAN Honglin, ZHOU Jianchuan, CHEN Liang, ZHANG Hongfu. Comparative Study on Evaluation of the Available Energy of Corn and Sorghum of Chicken by Free Feeding Method and Tube Feeding Method [J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53(11): 3907-3916.
[11]	SUN Dong, CAI Yinchuan, JIANG Siyu, LI Xuan, HAO Gang. Molecular Design, Structure and Activity Analysis of Antimicrobial Peptide Tachyplesin I [J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53(6): 1905-1913.
[12]	WANG Meng, LI Shangmin, SHEN Dan, HAN Guofeng, LI Yansen, DOU Xinhong, LI Chunmei. Effects of Dietary Different Whole-Plant Corn Silage Levels on Growth Performance, Slaughter Performance, Meat Quality and Serum Biochemical Parameters of Geese [J]. Acta Veterinaria et Zootechnica Sinica, 2021, 52(12): 3501-3511.
[13]	WANG Ruixiu, CHEN Zhongwei, LIU Qiang, ZHUANG Su. Effects of Synbiotics on Meat Quality, Antioxidant Capacity and Immune Function of Cherry Valley Ducks [J]. Acta Veterinaria et Zootechnica Sinica, 2021, 52(9): 2522-2533.
[14]	ZHANG Xiaojing, ZHANG Yangyang, ZHANG Xiaofeng, QIAO Hongxing, BIAN Chuanzhou. Isolation and Identification of Aflatoxin B₁ Degrading Bacillus amyloliquefaciens and Its in vitro Detoxification Effect [J]. Acta Veterinaria et Zootechnica Sinica, 2021, 52(8): 2291-2301.
[15]	JIA Hongmin, MA Yonghang, HE Pingli, QIAO Shiyan. Effects of Excessive Lysine on Weaned Piglets and Their Intestinal Epithelial Cells [J]. Acta Veterinaria et Zootechnica Sinica, 2021, 52(7): 1912-1926.