镰刀菌毒素对断奶仔猪肠道IL-1β和IL-6分布和表达的影响

doi:10.11843/j.issn.0366-6964.2016.10.022

Abstract

Abstract:

The aim of the present study was to investigate effects of Fusarium toxins on distribution and mRNA expression levels of intestinal IL-1β and IL-6 in post-weaning piglets.A total of 40 healthy piglets (Duroc×Landrace×Large White) aged at 35 d with an average body weight (8.45±0.94) kg were randomly allocated into two treatments with 20 in the control group (Control) and 20 in the test group (Fusarium Toxins).Piglets in the control group were fed a basal diet only，and piglets in the Fusarium toxins group were fed a test diet (0.90 mg•kg^-1 ZEN，1.43 mg•kg^-1 DON，5.85 mg•kg^-1 FUM).The experimental period was 35 d after 7 d adaptation.Then 10 piglets of each treatment were chosen to slaughter and sample.Results showed because of the Fusarium toxins，the positive cells of the small intestinal IL-1β and IL-6 were from dispersed in the lamina propria to villous lymphocytes concentration.But the IL-1β and IL-6 positive cells of the colon were mainly distributed in the lamina propria cells.And the IL-1β mRNA levels of duodenum，the IL-6 mRNA levels of duodenum and jejunum and the IL-1β and IL-6 mRNA levels of colon of the Fusarium toxins group were significantly higher (P<0.05) than that of the control.The mRNA levels of IL-1β and IL-6 had a correlation between small intestine and colon.In the present study，it suggested that Fusarium toxins exerted a deleterious effect on inflammatory response via distribution and mRNA expression levels of intestinal IL-1β and IL-6，which have a negative impact on immunity of piglets eventually.

Key words: Fusarium toxins, intestine, IL-1β, IL-6, piglets

CLC Number:

S859.87

CHEN Xiang-xing，ZHANG Chong-yu，HUANG Li-bo，LIU Fa-xiao，YANG Wei-ren，JIANG Shu-zhen. Effects of Fusarium Toxins on IL-1β and IL-6 in Post-weaning Piglets[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2016, 47(10): 2126-2135.

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Effects of Fusarium Toxins on IL-1β and IL-6 in Post-weaning Piglets

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