五氯柳胺口服混悬剂的制备及其含量测定

doi:10.11843/j.issn.0366-6964.2016.10.021

Abstract

Abstract:

The study aimed to prepare oxyclozanide oral suspension and evaluate its physical and chemical properties，and establish an HPLC method for the determination of oxyclozanide.The sedimentation volume ratio and redispersibility were used as variable factors，the single factor experiment and the quadratic regression orthogonal rotational combination design were carried out to optimize the prescription.Then，the shape，size of oxyclozanide suspension was measured by transmission electron microscopylaser and particle size analyzer，and the content of oxyclozanide in suspension was determined by HPLC.The result showed that the suspension (100 mL) was consisted of 3.2 g oxyclozanide，0.2 g carbomer 974p，0.3 g sodium dodecyl sulfate sodium salt，0.02 g methyl 4-hydroxybenzoate and 0.4 g sodium pyrosulfite.With good redispersibility，the sedimentation volume ratio of oxyclozanide suspension was 0.999.Excellent line relationship was obtained in the range of 18-100 μg•mL^-1 (r²=0.999 3).The oxyclozanide suspension was successfully prepared with simple preparation process，good stability and well quality-controlled product.

Key words: oxyclozanide suspension, quadratic regression orthogonal rotational combination design, determination of content, HPLC

CLC Number:

S859.5

ZHANG Ji-li，LI Bing，SI Hong-fei，GUO Xiao，ZHU Zhen，SHANG Xiao-fei，ZHOU Xu-zheng，ZHANG Ji-yu. Preparation and Content Measurement of Oxyclozanide Oral Suspension[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2016, 47(10): 2115-2125.

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Preparation and Content Measurement of Oxyclozanide Oral Suspension

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