流感病毒逃避宿主天然免疫抗病毒应答研究进展

doi:10.11843/j.issn.0366-6964.2015.04.003

Abstract

Abstract:

Influenza virus is an important respiratory pathogen，which can bring endemic infection in people every year，and can cause worldwide pandemic due to its easy variation of antigenicity.Influenza viruses can also spread in a variety of animal populations，transmit occasionally from animal species to the humans and spread in the population，resulting in potential threats to human health under certain conditions.Host innate immune response，especially early interferon response is the body’s first defense barrier against viral infections.Viruses must breakthrough that barrier in order to successfully infect the host.To fight viral infections，the host cells use a range of sophisticated anti-viral strategies：the cells firstly use pattern recognition receptor to recognize viral products，and then activate signaling cascades，leading to a range of interferon and other cytokines；downstream effector molecules are induced by interferons and inhibit viral replication；the activated cytokines contribute to adapted immune response.In the process of co-evolution with the host，influenza virus also develops perfect antagonist strategies to host interferon pathway，which help virus infect the host and spread efficiently in host cell.In recent years，the studies on how virus induces and modulates host innate immune response have made rapid development，and a large study found that the virus can utilize a variety of strategies to evade host antiviral response.Therefore，this review focuses on how influenza virus antagonizes host interferon production and evades cellular antiviral response，which will be contributed to uncover the pathogenicity mechanisms of influenza virus and reveal novel antiviral targets for the prevention and control of influenza infection.

Key words: influenza virus, innate immune, interferon, immune evasion

CLC Number:

LI Yong-tao，WANG Chuan-qing. Evasion of Host Innate Immune Antiviral Responses by Influenza Viruses[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2015, 46(4): 526-533.

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Evasion of Host Innate Immune Antiviral Responses by Influenza Viruses

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