脂肪分化相关信号通路及microRNA调节研究进展

doi:10.11843/j.issn.0366-6964.2015.04.002

Abstract

Abstract:

Content of body fat in domestic livestocks and poultry determines the meat quality.Adipocyte differentiation is a complex biological process regulated by many factors.Understanding the adipose differentiation-related signaling pathways and their miRNA regulations can reveal the molecular mechanisms of adipocyte differentiation.Based on introduction to the 6 important signaling pathways regulating adipocyte differentiation，biological functions and mechanisms of 8 miRNAs for promoting and another 8 miRNAs for inhibiting adipocyte differentiation were discussed.The function of target genes of these miRNAs in adipogenesis was summarized.Studies on the related miRNAs and their target genes provide theoretical bases for genetic improvement of meat quality traits in domestic livestocks and poultry.

Key words: adipocyte, adipogenic differentiation, signaling pathways, microRNA, target gene

CLC Number:

S813.3

JIA Xia-li，PAN Yang-yang，QIAO Li-ying，GUO Yun-yan，HU Zi-qiao，ZHANG Fang，LI Bao-jun，LIU Wen-zhong. Research Progress in Signaling Pathways and microRNA Regulation of Adipocyte Differentiation[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2015, 46(4): 518-525.

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Research Progress in Signaling Pathways and microRNA Regulation of Adipocyte Differentiation

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