长链非编码RNA与动物的基因表达调控

doi:10.11843/j.issn.0366-6964.2015.04.001

Abstract

Abstract:

Long noncoding RNA are a group of endogenous RNA molecules which exceed 200 nt in length，lack complete specific open reading frame，they don’t have the ability to encode proteins.But recent studies have shown that lncRNA participates in many important physiological processes，such as gene imprinting，X chromosome inactivation，and so on.They regulate gene expression mainly through the DNA methylation，Histone modification，chromatin remodeling.At the same time，lncRNA have important effect on the occurrence and development process of disease，and have very important significance to the diagnosis and treatment of disease.Therefore，this article analyzed the biological characteristics of lncRNA，lncRNA in epigenetic，transcriptional level post-transcriptional level，the role in stem cell and the research of the disease，elaborated the research progress of the current lncRNA，provided a reference for further study on the mechanism of lncRNA involved in the regulation of physiological processes.

Key words: lncRNA, epigenetics, ncRNA, gene imprinting, DNA methylation, Histone modifications

CLC Number:

S852.2

WANG Kang-yan，LING Ying-hui，ZHANG Xiao-rong. Research Progress in Regulation of Gene Expression of Long Noncoding RNA[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2015, 46(4): 509-517.

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Research Progress in Regulation of Gene Expression of Long Noncoding RNA

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