β-防御素的生物学特性及其在调控动物肠道屏障中的研究进展

doi:10.11843/j.issn.0366-6964.2025.03.003

Abstract

Abstract:

The intestinal mucosal barrier is the first line of defense against the invasion of foreign pathogenic substances, and its integrity is essential to maintain intestinal health. β-defensins are small molecular peptides widely distributed in mammalian epithelial cells. They have biological properties such as antimicrobial, anti-tumor, anti-inflammatory and immunomodulatory properties, and have a broad spectrum of antimicrobial activity, small molecular weight, and are not prone to drug-resistant. β-defensins can regulate intestinal barrier function by regulating intestinal flora, the expression of tight junction of intestinal epithelial cells, the secretion of bacteriostatic substances in intestinal epithelial cells, and the immune function of intestinal mucosa, thus maintaining the homeostasis of the intestinal environment. In this paper, the biological characteristics of β-defensins and its function mechanism, the regulation of β-defensins on animal intestinal barrier function, regulatory effect of feed additive on β-defensins were reviewed, in order to provide reference for its application in animal intestines.

Key words: β-defensins, biological characteristics, livestock and poultry, gut barrier

CLC Number:

S852.2

WANG Zhuo, ZHAO Yuwei, TU Yan, DIAO Qiyu, CUI Kai. Research Progress on Biological Characteristics of β-defensins and Their Roles in Regulating Intestinal Barrier in Animals[J]. Acta Veterinaria et Zootechnica Sinica, 2025, 56(3): 995-1005.

Figures/Tables 3

Fig. 1

Fig. 2

Table 1

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添加剂种类 Types of additives	饲料添加剂 Feed additive	添加剂量 Dose added	产生部位 Site of production	β-防御素类型 β-defensin types	参考文献 References
植物提取物 Plant extracts	槲皮素	0.02%~0.06%	肉鸡回肠	AvBD3、4、5、6、7、 8、9、10、11、13	[69]
	黄花蒿	0.1%	仔猪十二指肠、空肠、回肠	pBD1、pBD2、pBD3	[70]
	葛根多糖	0.8 g·kg^－1	小鼠小肠	总β-防御素	[71]
氨基酸 Amino acids	L-苏氨酸	1 mmol·L^－1	IPEC-J2	pBD-1、pBD-2、 pBD-3	[72]
小分子化合物 Small molecule compounds	烟酸	1×10⁷ TCID₅₀	断奶仔猪空肠、回肠	pBD-1、pBD-2	[73]
小分子化合物 Small molecule compounds	丁酸甘油酯	0.5%	断奶仔猪空肠、回肠	pBD1、pBD2、pBD3、 pBD114、pBD129	[74]
益生菌 Probiotics	双歧杆菌	1×10⁹ cfu·mL^－1	斑马鱼	zfbd-1, zfbd-2, zfbd-3	[75]
	罗伊氏乳杆菌	1×10⁸ CFU 菌液300 μL	鸡回肠和盲肠	AvBD10、 AvBD12↓	[76]
	酸化小儿球菌、粪肠球菌	2.5×10⁹ CFU·kg^－1、 1 g·kg^－1	肉鸡回肠	AvBD2、 AvBD9↓	[77]

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Research Progress on Biological Characteristics of β-defensins and Their Roles in Regulating Intestinal Barrier in Animals

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