刚地弓形虫AP2家族蛋白质研究进展

doi:10.11843/j.issn.0366-6964.2024.09.008

Abstract

Abstract:

Toxoplasma gondii is an obligate intracellular parasitic protozoan belonging to the phylum Apicomplexa, with a complex life cycle involving multiple hosts and stages. T. gondii has a sexual stage restricted to felid species, while the asexual stage occurs in most warm-blooded animals including humans. About one-third of the world's population is infected with toxoplasmosis, and it can also cause serious economic losses in the livestock industry. T. gondii has a sophisticated gene regulatory network that enables it to timely transcribe its own genes as it adapts to changes in the external environment during specific stages. However, little is known about its potential transcriptional regulatory mechanisms. It has been found that specific transcription factors (TFs) play an important role in eukaryotic transcriptional regulation, especially the apetala 2 (AP2) family of transcription factors, which are involved in T. gondii gene expression during different stages. These factors play a crucial role in the growth and development of parasites. This article reviews the research progress of the Apicomplexan AP2 (ApiAP2) family of proteins in T. gondii, combining recent research results, in order to lay a foundation for further study of the biological characteristics of T. gondii.

Key words: Toxoplasma gondii, specific transcription factors, gene, cyst

CLC Number:

S852.729

Xu GUO, Xiaoxiao CHEN, Yiming CHI, Wenyu MA, Mengze DU, Jian AN, Qiuming LI, Deqi YIN. Research Progress of Toxoplasma gondii AP2 Family[J]. Acta Veterinaria et Zootechnica Sinica, 2024, 55(9): 3824-3832.

Figures/Tables 2

Table 1

Overview of Toxoplasma gondii AP2 transcription factors"

基因号 Gene ID	氨基酸 Amino acid	基因描述 Gene description	功能 Function	参考文献 Reference
TGME49_306620	1 388 aa	转录因子AP2IX-9 AP2 domain transcription factor AP2IX-9	缓殖子发育的抑制因子 Inhibitory factors of bradyzoite development	[30]
TGME49_318610	1 369 aa	转录因子AP2IV-3 AP2 domain transcription factor AP2IV-3	缓殖子基因表达的激活剂 Activator of bradyzoite gene expression	[30]
TGME49_288950	951 aa	转录因子AP2IX-4 AP2 domain transcription factor AP2IX-4	促进组织包囊的形成 Promote the formation of tissue cyst	[25]
TGME49_315760	3 236 aa	转录因子AP2XI-4 AP2 domain transcription factor AP2XI-4	寄生虫分化和包囊形成过程中调节缓殖子基因表达 Regulation of bradyzoite gene expression during parasite differentiation and cyst formation	[31]
TGME49_289710	2 282 aa	转录因子AP2IX-5 AP2 domain transcription factor AP2IX-5	调控细胞周期和速殖子增殖 Regulation of cell cycle and tachyzoite proliferation	[27-28]
TGME49_217700	1 737 aa	转录因子AP2XII-2 AP2 domain transcription factor AP2XII-2	调控细胞周期S期和缓殖子分化 Regulation of cell cycle S-phase and bradyzoite differentiation	[36-37]
TGME49_318470	2 406 aa	转录因子AP2IV-4 AP2 domain transcription factor AP2IV-4	调节组织包囊的形成 Regulating the formation of tissue cysts	[23]
TGME49_216220	868 aa	转录因子AP2XI-5 AP2 domain transcription factor AP2XI-5	调节关键毒力因子的基因转录 Regulation of gene transcription of key virulence factors	[32]
TGME49_247730	1 502 aa	转录因子AP2XII-5 AP2 domain transcription factor AP2XII-5	调控弓形虫生活史各阶段基因的有序表达而影响毒株毒力 Regulating the orderly expression of genes at all stages of Toxoplasma gondii life cycle and affecting the virulence of the strain	[38-39]
TGME49_224050	868 aa	转录因子AP2X-4 AP2 domain transcription factor AP2X-4	调控基因转录；调节棒状体蛋白质的表达 Regulate gene transcription and the expression of rhoptry proteins	[38-39]
TGME49_218960	2 282 aa	转录因子AP2XII-1 AP2 domain transcription factor AP2XII-1	调控急性感染性速殖子阶段向有性裂殖子阶段的转变 Regulation of the transition from the acute infectious tachyzoite stage to the sexual cleavage stage	[33-34]
TGME49_310900	2 243 aa	转录因子AP2XI-2 AP2 domain transcription factor AP2XI-2	调控速殖子阶段向有性裂殖子阶段的转变 Regulation of the tachyzoite stage to the sexual cleavage stage	[33]

Table 1

Fig. 1

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