肉鸡骨骼发育的调控机制

doi:10.11843/j.issn.0366-6964.2022.07.003

Abstract

Abstract: Bone development is mainly accomplished by endochondral ossification in broilers. In the process of endochondral ossification, growth plate chondrocytes undergo proliferation, hypertrophy, transdifferentiation and cartilage matrix mineralization, and eventually osteoblasts gradually replace cartilage primordia to achieve linear bone elongation. Endochondral osteogenesis is a complex and precise process, regulated by multiple signaling and transcription factors such as SOX9, RUNX2, MEF2C, OSX, TGF-β, BMP2, FGFs, IHH and PTHrP, etc. These regulators are expressed by chondrocytes in different zones of the growth plate or specifically regulate chondrocyte proliferation and differentiation, vascular invasion and so on. In poultry breeding, leg disease often occurs in broilers and is difficult to cure, but there are few studies on the pathogenesis of broiler leg disease. This article reviewed the process of bone formation and its specific molecular regulation mechanism, providing reference for understanding the pathogenesis and reasonable treatment of broiler leg disease.

Key words: bone, growth plate, chondrocyte, endochondral ossification, regulatory factor, broiler

CLC Number:

S831.2

WANG Cuiyue, LI Mingrui, GAO Yushi, CHEN Dawei. Regulation Mechanism of Bone Development in Broilers[J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53(7): 2057-2065.

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Regulation Mechanism of Bone Development in Broilers

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