Acta Veterinaria et Zootechnica Sinica ›› 2022, Vol. 53 ›› Issue (7): 2057-2065.doi: 10.11843/j.issn.0366-6964.2022.07.003
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WANG Cuiyue1,2, LI Mingrui3, GAO Yushi1, CHEN Dawei1*
Received:
2021-10-14
Online:
2022-07-23
Published:
2022-07-23
CLC Number:
WANG Cuiyue, LI Mingrui, GAO Yushi, CHEN Dawei. Regulation Mechanism of Bone Development in Broilers[J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53(7): 2057-2065.
[1] | HUANG S C,KONG A A,CAO Q Q,et al.The role of blood vessels in broiler chickens with tibial dyschondroplasia[J].Poult Sci,2019,98(12):6527-6532. |
[2] | GUO Y P,TANG H H,WANG X N,et al.Clinical assessment of growth performance,bone morphometry,bone quality,and serum indicators in broilers affected by valgus-varus deformity[J].Poult Sci,2019,98(10):4433-4440. |
[3] | LIU K P,FAN R B,ZHOU Z L.Endoplasmic reticulum stress,chondrocyte apoptosis and oxidative stress in cartilage of broilers affected by spontaneous femoral head necrosis[J].Poult Sci,2021,100(8):101258. |
[4] | BLUMER M J F.Bone tissue and histological and molecular events during development of the long bones[J].Ann Anat,2021,235:151704. |
[5] | TATA Z,MERCERON C,SCHIPANI E.Fetal growth plate cartilage:histological and immunohistochemical techniques[M]//HAQQI T M,LEFEBVRE V.Chondrocytes:Methods and Protocols.New York:Humana,2021:53-84. |
[6] | KOYAMA E,MUNDY C,SAUNDERS C,et al.Premature growth plate closure caused by a hedgehog cancer drug is preventable by co-administration of a retinoid antagonist in mice[J].J Bone Miner Res,2021,36(7):1387-1402. |
[7] | LUI J C.Home for a rest:Stem cell niche of the postnatal growth plate[J].J Endocrinol,2020,246(1):R1-R11. |
[8] | ROLIAN C.Endochondral ossification and the evolution of limb proportions[J].Wiley Interdiscip Rev Dev Biol,2020,9(4):e373. |
[9] | MEHMOOD K,ZHANG H,JIANG X,et al.Ligustrazine recovers thiram-induced tibial dyschondroplasia in chickens:Involvement of new molecules modulating integrin beta 3[J].Ecotoxicol Environ Saf,2019,168:205-211. |
[10] | ZHANG H,MEHMOOD K,JIANG X,et al.Effect of tetramethyl thiuram disulfide (thiram) in relation to tibial dyschondroplasia in chickens[J].Environ Sci Pollut Res,2018,25(28):28264-28274. |
[11] | WANG J,WANG Z Y,WANG Z J,et al.Effects of manganese deficiency on chondrocyte development in tibia growth plate of Arbor Acres chicks[J].J Bone Miner Metab,2015,33(1):23-29. |
[12] | KOZHEMYAKINA E,LASSAR A B,ZELZER E.A pathway to bone:Signaling molecules and transcription factors involved in chondrocyte development and maturation[J].Development,2015,142(5):817-831. |
[13] | LEFEBVRE V.Toward understanding the functions of the two highly related Sox5 and Sox6 genes[J].J Bone Miner Metab,2002,20(3):121-130. |
[14] | JIANG X,LI A Y,WANG Y P,et al.Ameliorative effect of naringin against thiram-induced tibial dyschondroplasia in broiler chicken[J].Environ Sci Pollut Res,2020,27(10):11337-11348. |
[15] | YAO W Y,ZHANG H,JIANG X,et al.Effect of total flavonoids of Rhizoma drynariae on tibial dyschondroplasia by regulating BMP-2 and runx2 expression in chickens[J].Front Pharmacol,2018,9:1251. |
[16] | WANG C Y,XIA W H,WANG L,et al.Manganese deficiency induces avian tibial dyschondroplasia by inhibiting chondrocyte proliferation and differentiation[J].Res Vet Sci,2021,140:164-170. |
[17] | DE OLIVEIRA H C,IBELLI A M G,GUIMARÃES S E F,et al.RNA-seq reveals downregulated osteochondral genes potentially related to tibia bacterial chondronecrosis with osteomyelitis in broilers[J].BMC Genet,2020,21(1):58. |
[18] | LEUNG V Y L,GAO B,LEUNG K K H,et al.SOX9 governs differentiation stage-specific gene expression in growth plate chondrocytes via direct concomitant transactivation and repression[J].PLoS Genet,2011,7(11):e1002356. |
[19] | LEFEBVRE V,ANGELOZZI M,HASEEB A.SOX9 in cartilage development and disease[J].Curr Opin Cell Biol,2019,61:39-47. |
[20] | CHENG A X,GENEVER P G.SOX9 determines RUNX2 transactivity by directing intracellular degradation[J].J Bone Miner Res,2010,25(12):2680-2689. |
[21] | DY P,WANG W H,BHATTARAM P,et al.Sox9 directs hypertrophic maturation and blocks osteoblast differentiation of growth plate chondrocytes[J].Dev Cell,2012,22(3):597-609. |
[22] | KOMORI T.Runx2,an inducer of osteoblast and chondrocyte differentiation[J].Histochem Cell Biol,2018,149(4):313-323. |
[23] | QIN X,JIANG Q,NAGANO K,et al.Runx2 is essential for the transdifferentiation of chondrocytes into osteoblasts[J].PLoS Genet,2020,16(11):e1009169. |
[24] | CHEN H Y,GHORI-JAVED F Y,RASHID H,et al.Runx2 regulates endochondral ossification through control of chondrocyte proliferation and differentiation[J].J Bone Miner Res,2014,29(12):2653-2665. |
[25] | LAURIE L E,KOKUBO H,NAKAMURA M,et al.The transcription factor hand1 is involved in Runx2-Ihh-regulated endochondral ossification[J].PLoS One,2016,11(2):e0150263. |
[26] | ARNOLD M A,KIM Y,CZUBRYT M P,et al.MEF2C transcription factor controls chondrocyte hypertrophy and bone development[J].Dev Cell,2007,12(3):377-389. |
[27] | TAN Z J,NIU B,TSANG K Y,et al.Synergistic co-regulation and competition by a SOX9-GLI-FOXA phasic transcriptional network coordinate chondrocyte differentiation transitions[J].PLoS Genet,2018,14(4):e1007346. |
[28] | IONESCU A,KOZHEMYAKINA E,NICOLAE C,et al.FoxA family members are crucial regulators of the hypertrophic chondrocyte differentiation program[J].Dev Cell,2012,22(5):927-939. |
[29] | CONNELLY Z M,JIN R J,ZHANG J H,et al.FOXA2 promotes prostate cancer growth in the bone[J].Am J Transl Res,2020,12(9):5619-5629. |
[30] | NISHIMURA R,WAKABAYASHI M,HATA K,et al.Osterix regulates calcification and degradation of chondrogenic matrices through matrix metalloproteinase 13(MMP13) expression in association with transcription factor Runx2 during endochondral ossification[J].J Biol Chem,2012,287(40):33179-33190. |
[31] | NAKASHIMA K,ZHOU X,KUNKEL G,et al.The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation[J].Cell,2002,108(1):17-29. |
[32] | HAN Y,KIM Y M,KIM H S,et al.Melatonin promotes osteoblast differentiation by regulating osterix protein stability and expression[J].Sci Rep,2017,7(1):5716. |
[33] | AMARILIO R,VIUKOV S V,SHARIR A,et al.HIF1α regulation of Sox9 is necessary to maintain differentiation of hypoxic prechondrogenic cells during early skeletogenesis[J].Development,2007,134(21):3917-3928. |
[34] | MA L,YANG Z Q,DING J L,et al.Function and regulation of transforming growth factor β1 signalling in antler chondrocyte proliferation and differentiation[J].Cell Prolif,2019,52(4):e12637. |
[35] | KANG J S,ALLISTON T,DELSTON R,et al.Repression of Runx2 function by TGF-β through recruitment of class II histone deacetylases by Smad3[J].EMBO J,2005,24(14):2543-2555. |
[36] | HORITA M,NISHIDA K,HASEI J,et al.Involvement of ADAM12 in chondrocyte differentiation by regulation of TGF-β1-induced IGF-1 and RUNX-2 expressions[J].Calcif Tissue Int,2019,105(1):97-106. |
[37] | YODTHONG T,KEDJARUNE-LEGGAT U,SMYTHE C,et al.Enhancing activity of Pleurotus sajor-caju (Fr.) sing β-1,3-glucanoligosaccharide (Ps-GOS) on proliferation,differentiation,and mineralization of MC3T3-E1 cells through the involvement of BMP-2/Runx2/MAPK/Wnt/β-catenin signaling pathway[J].Biomolecules,2020,10(2):190. |
[38] | YOON B S,POGUE R,OVCHINNIKOV D A,et al.BMPs regulate multiple aspects of growth-plate chondrogenesis through opposing actions on FGF pathways[J].Development,2006,133(23):4667-4678. |
[39] | NISHIMURA R,HATA K,MATSUBARA T,et al.Regulation of bone and cartilage development by network between BMP signalling and transcription factors[J].J Biochem,2012,151(3):247-254. |
[40] | KARUPPAIAH K,YU K,LIM J,et al.FGF signaling in the osteoprogenitor lineage non-autonomously regulates postnatal chondrocyte proliferation and skeletal growth[J].Development,2016,143(10):1811-1822. |
[41] | WANG Y,YANG T,LIU Y D,et al.Decrease of miR-195 promotes chondrocytes proliferation and maintenance of chondrogenic phenotype via targeting FGF-18 pathway[J].Int J Mol Sci,2017,18(5):975. |
[42] | KREJCI P,MASRI B,FONTAINE V,et al.Interaction of fibroblast growth factor and C-natriuretic peptide signaling in regulation of chondrocyte proliferation and extracellular matrix homeostasis[J].J Cell Sci,2005,118(21):5089-5100. |
[43] | CINQUE L,FORRESTER A,BARTOLOMEO R,et al.FGF signalling regulates bone growth through autophagy[J].Nature,2015,528(7581):272-275. |
[44] | OHBA S.Hedgehog signaling in skeletal development:Roles of Indian hedgehog and the mode of its action[J].Int J Mol Sci,2020,21(18):6665. |
[45] | DENG A,ZHANG H Q,HU M Y,et al.The inhibitory roles of Ihh downregulation on chondrocyte growth and differentiation[J].Exp Ther Med,2018,15(1):789-794. |
[46] | ST-JACQUES B,HAMMERSCHMIDT M,MCMAHON A P.Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation[J].Genes Dev,1999,13(16):2072-2086. |
[47] | MARTIN T J.Parathyroid hormone-related protein,its regulation of cartilage and bone development,and role in treating bone diseases[J].Physiol Rev,2016,96(3):831-871. |
[48] | KARAPLIS A C,KRONENBERG H M.Physiological roles for parathyroid hormone-related protein:lessons from gene knockout mice[J].Vitam Horm,1996,52:177-193. |
[49] | HAN X S,ZHUANG Y F,ZHANG Z H,et al.Regulatory mechanisms of the Ihh/PTHrP signaling pathway in fibrochondrocytes in entheses of pig Achilles tendon[J].Stem Cells Int,2016,2016:8235172. |
[50] | PEAKE N J,HOBBS A J,PINGGUAN-MURPHY B,et al.Role of C-type natriuretic peptide signalling in maintaining cartilage and bone function[J].Osteoarthritis Cartilage,2014,22(11):1800-1807. |
[51] | FUJII T,HIROTA K,YASODA A,et al.Rats deficient C-type natriuretic peptide suffer from impaired skeletal growth without early death[J].PLoS One,2018,13(3):e0194812. |
[52] | LORGET F,KACI N,PENG J,et al.Evaluation of the therapeutic potential of a CNP analog in a Fgfr3 mouse model recapitulating achondroplasia[J].Am J Hum Genet,2012,91(6):1108-1114. |
[53] | CHUA K,LEE V K,CHAN C,et al.Hematopoietic wnts modulate endochondral ossification during fracture healing[J].Front Endocrinol,2021,12:667480. |
[54] | KOBAYASHI Y,UEHARA S,UDAGAWA N,et al.Regulation of bone metabolism by Wnt signals[J].J Biochem),2016,159(4):387-392. |
[55] | DIEDERICHS S,TONNIER V,MÄRZ M,et al.Regulation of WNT5A and WNT11 during MSC in vitro chondrogenesis:WNT inhibition lowers BMP and hedgehog activity,and reduces hypertrophy[J].Cell Mol Life Sci,2019,76(19):3875-3889. |
[56] | LIU S,ZHANG E J,YANG M L,et al.Overexpression of Wnt11 promotes chondrogenic differentiation of bone marrow-derived mesenchymal stem cells in synergism with TGF-β[J].Mol Cell Biochem,2014,390(1-2):123-131. |
[57] | ZHANG H,MEHMOOD K,LI K,et al.Icariin ameliorate thiram-induced tibial dyschondroplasia via regulation of WNT4 and VEGF expression in broiler chickens[J].Front Pharmacol,2018,9:123. |
[58] | DUAN X,MURATA Y,LIU Y,et al.Vegfa regulates perichondrial vascularity and osteoblast differentiation in bone development[J].Development,2015,142(11):1984-1991. |
[59] | DIOMEDE F,MARCONI G D,FONTICOLI L,et al.Functional relationship between osteogenesis and angiogenesis in tissue regeneration[J].Int J Mol Sci,2020,21(9):3242. |
[60] | ZELZER E,MAMLUK R,FERRARA N,et al.VEGFA is necessary for chondrocyte survival during bone development[J].Development,2004,131(9):2161-2171. |
[61] | HUANG S C,LI L,REHMAN M U,et al.Tibial growth plate vascularization is inhibited by the dithiocarbamate pesticide thiram in chickens:potential relationship to peripheral platelet counts alteration[J].Environ Sci Pollut Res,2019,26(36):36322-36332. |
[62] | STEGEN S,LAPERRE K,EELEN G,et al.HIF-1α metabolically controls collagen synthesis and modification in chondrocytes[J].Nature,2019,565(7740):511-515. |
[63] | PFANDER D,CRAMER T,SCHIPANI E,et al.HIF-1α controls extracellular matrix synthesis by epiphyseal chondrocytes[J].J Cell Sci,2003,116(9):1819-1826. |
[64] | ZHOU N,HU N,LIAO J Y,et al.Hif-1α as a regulator of BMP2-induced chondrogenic differentiation,osteogenic differentiation,and endochondral ossification in stem cells[J].Cell Physiol Biochem,2015,36(1):44-60. |
[65] | SCHLEGEL W,HALBAUER D,RAIMANN A,et al.IGF expression patterns and regulation in growth plate chondrocytes[J].Mol Cell Endocrinol,2010,327(1-2):65-71. |
[66] | RICO-LLANOS G A,BECERRA J,VISSER R.Insulin-like growth factor-1(IGF-1) enhances the osteogenic activity of bone morphogenetic protein-6(BMP-6) in vitro and in vivo,and together have a stronger osteogenic effect than when IGF-1 is combined with BMP-2[J].J Biomed Mater Res Part A,2017,105(7):1867-1875. |
[67] | MELNIK S,GABLER J,DREHER S I,et al.miR-218 affects hypertrophic differentiation of human mesenchymal stromal cells during chondrogenesis via targeting RUNX2,MEF2C,and COL10A1[J].Stem Cell Res Ther,2020,11(1):532. |
[68] | OKA S,LI X Y,ZHANG F Z,et al.MicroRNA-21 facilitates osteoblast activity[J].Biochem Biophys Rep,2021,25:100894. |
[69] | ZHANG B Y,WANG C Y,ZHANG Y,et al.A CRISPR-engineered swine model of COL2A1 deficiency recapitulates altered early skeletal developmental defects in humans[J].Bone,2020,137:115450. |
[70] | ZHOU X P,MA C Y,HU B,et al.FoxA2 regulates the type II collagen-induced nucleus pulposus-like differentiation of adipose-derived stem cells by activation of the Shh signaling pathway[J].FASEB J,2018,32(12):6582-6595. |
[71] | INADA M,WANG Y M,BYRNE M H,et al.Critical roles for collagenase-3(Mmp13) in development of growth plate cartilage and in endochondral ossification[J].Proc Natl Acad Sci U S A,2004,101(49):17192-17197. |
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