从有丝分裂到肿瘤形成：Plk1功能研究进展

doi:10.11843/j.issn.0366-6964.2015.05.001

Abstract

Abstract:

Polo-like kinase 1 (Plk1)，a well-characterized member of serine/threonine kinases Plk family，is highly conserved among eukaryotes.Plk1 has important regulatory role in cell cycles.It mediates a variety of cell cycle events，including centrosome maturation，bipolar spindle formation，mitosis entry，chromatin lining and cytokinesis by phosphorylation of different specific substrates.Recent studies suggest that Plk1，beyond its traditional function in mitosis，is also well involved in the DNA damage response，carcinogenesis and early embryonic development.In this review，the roles of Plk1 in mitosis，DNA damage response，carcinogenesis and early embryonic development will be focused，which will provide a reference for related studies.

CLC Number:

S857

WANG Zhe，JU Shi-qiang，RUI Rong. From Mitosis to Carcinogenesis，the Research Progress on Plk1’s Function[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2015, 46(5): 681-688.

0
/ / Recommend

Add to citation manager EndNote|Reference Manager|ProCite|BibTeX|RefWorks

URL: https://www.xmsyxb.com/EN/10.11843/j.issn.0366-6964.2015.05.001

https://www.xmsyxb.com/EN/Y2015/V46/I5/681

References

［1］SUNKEL C E，GLOVER D M.Polo，amitotic mutant of Drosophila displaying abnormal spindle poles［J］.J Cell Sci，1988，1（89）：25-38.
［2］GUILLERMO C R，GERARD M，MARCOS M.From Plk1 to Plk5：Functional evolution of polo-like kinases ［J］.Cell Cycle，2011，10（14）：2255-2262.
［3］PARK J E，SOUNG N K，JUHMURA Y，et al.Polo-box domain：a versatile mediator of Polo-like kinase function ［J］.Cell Mol Life Sci，2010，67（12）：1957-1970.
［4］ELIA A E，RELLOS P，HAIRE L F.The molecular basis for phosphodependent substrate targeting and regulation of Plks by the Polo-box domain ［J］.Cell，2003，115（1）：83-95.
［5］NEEF R，GRUNEBERG U，KOPAJTICH R，et al.Choice of Plk1 docking partners during mitosis and cytokinesis is controlled by the activation state of Cdk1 ［J］.Nat Cell Biol，2007，9（4）：436-444.
［6］LIU Z X，REN J，CAO J，et al.Systematic analysis of the Plk-mediated phosphoregulation in eukaryotes ［J］.Briefings Bioinform，2013，14（3）：344-360.
［7］PETRONCZKI M，LÉNÁRT P，PETERS J M.Polo on the rise-from mitotic entry to cytokinesis with Plk1 ［J］.Dev Cell，2008，14（5）：646-659.
［8］STREBHARDT K.Multifaceted polo-like kinases：drug targets and antitargets for cancer therapy ［J］.Nat Rev Drug Discov，2010，9（8）：643-660.
［9］CASENGHI M，BARR F A，NIGG E A.Phosphorylation of Nlp by Plk1 negatively regulates its dynein-dynactin-dependent targeting to the centrosome ［J］.J Cell Sci，2005，118：5101-5108.
［10］OSHIMORI N，OHSUGI M，YAMAMOTO T.The Plk1 target Kizuna stabilizes mitotic centrosomes to ensure spindle bipolarity ［J］.Nat Cell Biol，2006，8（10）：1095-1101.
［11］张亮，曹燕华，卢帅，等.靶向Polo样激酶1底物结合区：PBD1抑制剂的研究进展［J］.药学学报，2013，48（3）：315-324.
ZHANG L， CAO Y H， LU S， et al.Targeting the substrate binding domain of polo-like kinase 1：advances in the study of PBD1 inhibitors ［J］.Acta Pharmaceutica Sinica，2013，48（3）：315-324.(in Chinese)
［12］BARR A R，GERGELY F.Aurora-A：the maker and breaker of spindle poles ［J］.J Cell Sci，2007，120（17）：2987-2996.
［13］MACÜREK L，LINDQVIST A，LIM D，et al.Polo-like kinase-1 is activated by Aurora A to promote checkpoint recovery［J］.Nature，2008，455（7209）：119-123.
［14］SEKI A，COPPINGER J A，JANG C Y，et al.Bora and the kinase Aurora A cooperatively activate the kinase Plk1 and control mitotic entry ［J］.Science，2008，320（5883）：1655-1658.
［15］MACUREK L，LINDQVIST A，MEDEMA R H.Aurora-A and Bora join the game of polo ［J］.Cancer Res，2009，69（11）：4555-4558.
［16］WYTSE B，LIBOR M，RAIMUNDO F，et al.Bora and Aurora-A continue to activate Plk1 in mitosis ［J］. J Cell Sci，2014，127：801-811.
［17］CHAN E H，SANTAMARIA A，SILLJÉ H H，et al.Plk1 regulates mitotic Aurora A function through beta TrCP-dependent degradation of hBora ［J］.Chromosoma，2008，117（5）：457-469.
［18］LINDQVIST A，RODRÍGUEZ-BRAVO V，MEDEMA R H.The decision to enter mitosis：feedback and redundancy in the mitotic entry network ［J］.J Cell Biol，2009，185（2）：193-202.
［19］WÄSCH R，ENGELBERT D.Anaphase-promoting complex-dependent proteolysis of cell cycle regulators and genomic instability of cancer cells ［J］.Oncogene，2005，24（1）：1-10.
［20］VAN LEUKEN R，CLIJSTERS L，WOLTHUIS R.To cell cycle，swing the APC/C ［J］.Biochim Biophys Acta，2008，1786（1）：49-59.
［21］AHONEN L J，KALLIO M J，DAUM J R，et al.Polo-like kinase1 creates the tension-sensing 3F3/2 phosphoepitope and modulates the association of spindle-checkpoint proteins at kinetochores［J］.Curr Biol，2005，15：1078-1089.
［22］NEEF R，GRUNEBERG U，KOPAJTICH R，et al.Choice of Plk1 docking partners during mitosis and cytokinesis is controlled by the activation state of Cdk1［J］.Nat Cell Biol，2007，9（4）：436-444.
［23］LIEBER M R.The mechanism of human nonhomologous DNA end joining ［J］. J Biol Chem，2008，283（1）：1-5.
［24］CALSOU P，DELTEIL C，FRIT P，et al.Coordinated assembly of Ku and p460 subunits of the DNA-dependent protein kinase on DNA ends is necessary for XRCC4-ligase IV recruitment［J］.J Mol Biol，2003，326（1）：93-103.
［25］HELLEDAY T.Pathways for mitotic homologous recombination in mammalian cells ［J］.Mutat Res，2003，532（1-2）：103-115.
［26］QIN B，GAO B，YU J，et al.Ataxia telangiectasia-mutated- and Rad3-related protein regulates the DNA damage-induced G2/M checkpoint through the Aurora A cofactor Bora protein［J］.J Biol Chem，2013，288：16139-16144.
［27］CICCIA A，ELLEDGE S J.The DNA damage response：making it safe to play with knives［J］.Mol Cell，2010，40（2）：179-204.
［28］孙佳，李胜范，郑丽丽.ATM/ATR在DNA损伤反应中的作用［J］.中华临床医师杂志(电子版)，2011，6：1683-1686.
SUN J，LI S F，ZHENG L L.The role of ATM/ATR in DNA damage response ［J］.Chinese Journal of Clinicians (Electronic Edition)，2011，6：1683-1686.(in Chinese)
［29］DONZELLI M，DRAETTA G F.Regulating mammalian checkpoints through Cdc25 inactivation［J］.EMBO Rep，2003，4（7）：671-677.
［30］VAN VUGT，BRÁS A，MEDEMA R H.Polo-like kinase-1 controls recovery from a G2 DNA damage-induced arrest in mammalian cells［J］.Mol Cell，2004，15（5）：799-811.
［31］KUMAGAI A，DUNPHY W G.Claspin，a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts［J］.Mol Cell，2000，6（4）：839-849.
［32］MAMELY I，VAN VUGT M A，SMITS V A，et al.Polo-like kinase-1 controls proteasome-dependent degradation of Claspin during checkpoint recovery［J］. Curr Biol，2006，16（19）：1950-1955.
［33］YATA K，LLOYD J，MASLEN S，et al.Plk1 and CK2 act in concert to regulate Rad51 during DNA double strand break repair ［J］.Mol Cell，2012，45（3）：371-383.
［34］HYUN S Y，ROSEN E M，JANG Y J.Novel DNA damage checkpoint in mitosis：Mitotic DNA damage induces re-replication without cell division in various cancer cells［J］.Biochem Biophys Res，2012，423（3）： 593-599.
［35］MEEK D W.Tumour suppression by p53：a role for the DNA damage response?［J］.Nat Rev Cancer， 2009，9（10）：714-723.
［36］ZHOU Z，CAO J X，LI S Y，et al.p53 Suppresses E2F1-dependent Plk1 expression upon DNA damage by forming p53-E2F1-DNA complex［J］.Exp Cell Res，2013，319（20）：3104-3115.
［37］LIN Y C，SUN S H，WANG F F.Suppression of Polo like kinase 1 (Plk1) by p21(Waf1) mediates the p53-dependent prevention of caspase-independent mitotic death［J］.Cell Signal，2011，23（11）：1816-1823.
［38］PANDIT B，HALASI M，GARTEL A L.p53 negatively regulates expression of FoxM1［J］.Cell Cycle，2009，8（20）：3425-3427.
［39］ANDO K，OZAKI T，YAMAMOTO H，et al.Polo-like kinase 1 (Plk1) inhibits p53 function by physical interaction and phosphorylation［J］.J Biol Chem，2004，279（24）：25549-25561.
［40］RILEY T.Transcriptional control of human p53-regulated genes［J］. Cell Biol，2008，9：402-412.
［41］YANG X，LI H，ZHOU Z，et al.Plk1-mediated phosphorylation of Topors regulates p53 stability［J］. J Biol Chem，2009，284（28）：18588-18592.
［42］LIU X S，LI H，SONG B，et al.Polo-like kinase 1 phosphorylation of G2 and Sphase-expressed 1 protein is essential for p53 inactivation during G2 checkpoint recovery［J］.EMBO Rep，2009，11（8）：626-632.
［43］TRAVIS L S，MARK C L，NIHAL A.Modulating polo-like kinase 1 as a means for cancer chemoprevention［J］. Pharm Res，2010，27（6）：989-998.
［44］TAKAI N，HAMANAKA R，YOSHIMATSU J，et al.Polo-like kinases (Plks) and cancer［J］.Oncogene，2005，24（2）：287-291.
［45］CHOI B，PAGANO M，DAI W.Plk1 phosphorylates PTEN and regulates its mitotic activity during the cell cycle［J］.J Biol Chem，2014，289(20):14066-14074.
［46］SIMIZU S，OSADA H.Mutations in the Plk gene lead to instability of Plk protein in human tumour cell lines［J］.Nat Cell，2000，2（11）： 852-854.
［47］LU L Y，WOOD J L，MINTER-DYKHOUSE K，et al.Polo-like kinase 1 is essential for early embryonic development and tumor suppression［J］. Mol Cell Biol，2008，28（22）： 6870-6876.
［48］张哲.Plk1和mTOR激酶在小鼠受精卵早期发育中作用的研究［D］.沈阳：中国医科大学，2008.
ZHANG Z.Involvement of Plk1 and mTOR in early development of mouse fertilized egg ［D］.Shenyang：China Medical University，2008.(in Chinese)
［49］JEONG K，JEONG J Y，LEE H O，et al.Inhibition of Plk1 induces mitotic infidelity and embryonic growth defects in developing zebrafish embryos［J］. Dev Biol，2010，345（1）：34-48.

[1]	WANG Ruiling, WANG Xueyan, WANG Feifei, KONG Weiyi, MAO Yongxia, LIU Xin, DING Hui, XU Lihua, GUO Yansheng. Study on the Changes of Blood Oxidized Lipid Group in Postpartum Dairy Cows with Acute Endometritis [J]. Acta Veterinaria et Zootechnica Sinica, 2024, 55(1): 373-387.
[2]	XUE Linli, SUN Rui, HAO Xiaojing, CAO Xiaorui, WANG Haidong, LU Jiayin. The Promoting Effect Analysis of Danshensu on Skeletal Muscle Repair and Regeneration after Skeletal Muscle Injury in Mice based on a Mouse Skeletal Muscle Injury Model [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(12): 5252-5263.
[3]	GAO Pingping, FU Jinyu, WANG Liyang, SHI Shuobo, ZHANG Yueping, ZHANG Di. Rapid RPA-CRISPR/Cas12a Detection Platform for Dermatophytes in Dogs and Cats [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(11): 4702-4711.
[4]	GUO Yizhe, LI Zhendong, ZHAO Xingkai, LI Shuai, GAO Hang, ZHOU Zhenlei. Anesthetic Effects and Echocardiography in Cats following Using Alfaxalone Alone or in Combination with Dexmedetomidine [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(11): 4786-4797.
[5]	XU Haojie, LIAN Shicun, DAI Pengxiu, ZHANG Xinke. Application of Immediate Implant Placement Technique in Repairing Molar Defects of Dogs [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(11): 4798-4804.
[6]	DAI Yuexin, YANG Lifeng, ZHAO Deming, ZHOU Xiangmei. A Retrospective Pathological Study of Odontogenic Tumors in Dogs and Cats [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(10): 4372-4378.
[7]	XU Huihao, JIAO Yien, ZHENG Xiaobo, ZHANG Zhipeng, YANG Lihui, LIN Jinzhou, WANG Libo, TANG Jing, LI Qijuan, LIU Jiangyu, CHEN Ziyang, HU Xiaoyan, PIAO Xueling, ZHANG Hui, GAN Ling. A Large Retrospective Study on the Treatment of Corneal Diseases in Dogs and Cats with a New Type of Bioengineered Cornea Transplantation [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(10): 4389-4402.
[8]	DAI Rongquan, LI Hui, ZHANG Bin, LI Yi, YUAN Zhankui. Computed Tomography Angiography Diagnosis and Surgery Outcome in Two Vascular Ring Anomaly Dogs [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(10): 4433-4438.
[9]	JIAO Guangming, LÜ Yingguang, SANG Jinfang, KOU Zhipeng, LIU Tao, WANG Yue, LU Xiangyu, PIAO Chenxi, MA Yajun, ZHANG Jiantao, WANG Hongbin. Effect of Adipose Mesenchymal Stem Cells in Combination with Methylprednisolone on Allogeneic Skin Grafts in Minipigs [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(8): 3533-3545.
[10]	GAO Kangkang, YI Yanyan, ZHAO Yiteng, LIN Pengfei, CHEN Huatao, JIN Yaping. Protective Effect of Endoplasmic Reticulum Stress Preadaptation on LPS-Induced Inflammatory Response in Goat Endometrial Epithelial Cells [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(8): 3546-3556.
[11]	ZHAO Wanli, CAO Qiqi, YANG Yue, DENG Zhaoju, XU Chuang. The Interaction between Gastrointestinal Microbiota and Mucosal Immunity in Health of Perinatal Dairy Cows [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(7): 2751-2760.
[12]	XU Huihao, FENG Xueqian, PIAO Xueling, SHEN Xiaojun, ZHENG Xiaobo, YANG Heng, LIN Jiahao, JIN Yipeng, LIN Degui. Comparative Study on Different Methods of Collection, Isolation, Culture and Identification of Feline Limbal Stem Cells [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(7): 3091-3101.
[13]	ZHANG Yan, LIU Jiayue, WU Meijin, ZHOU Jiahao, DIAO Hongxiu. Research Progress of Non-coding RNA as A Potential Biomarker for Canine Tumors [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(6): 2264-2271.
[14]	REN Xiaoli, FAN Yuying, HUANGFU Heping, LIU Yun, SHI Dongmei. Effect of GSK126 on Epithelial-mesenchymal Transition of Canine Mammary Tumor Cells [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(4): 1721-1729.
[15]	CHEN Yongping, KOU Yuhong, JIAO Wenjing, HOU Xiaoyu, FAN Honggang. Effect of Coenzyme Q10 on LPS-induced Acute Lung Injury in Mice [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(4): 1730-1741.

From Mitosis to Carcinogenesis，the Research Progress on Plk1’s Function

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments