脂肪分化相关信号通路及microRNA调节研究进展

doi:10.11843/j.issn.0366-6964.2015.04.002

Abstract

Abstract:

Content of body fat in domestic livestocks and poultry determines the meat quality.Adipocyte differentiation is a complex biological process regulated by many factors.Understanding the adipose differentiation-related signaling pathways and their miRNA regulations can reveal the molecular mechanisms of adipocyte differentiation.Based on introduction to the 6 important signaling pathways regulating adipocyte differentiation，biological functions and mechanisms of 8 miRNAs for promoting and another 8 miRNAs for inhibiting adipocyte differentiation were discussed.The function of target genes of these miRNAs in adipogenesis was summarized.Studies on the related miRNAs and their target genes provide theoretical bases for genetic improvement of meat quality traits in domestic livestocks and poultry.

CLC Number:

S813.3

JIA Xia-li，PAN Yang-yang，QIAO Li-ying，GUO Yun-yan，HU Zi-qiao，ZHANG Fang，LI Bao-jun，LIU Wen-zhong. Research Progress in Signaling Pathways and microRNA Regulation of Adipocyte Differentiation[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2015, 46(4): 518-525.

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References

［1］LUKIC L，LALIC N M，RAJKOVIC N，et al.Hypertension in obese type 2 diabetes patients is associated with increases in insulin resistance and IL-6 cytokine levels：Potential targets for an efficient preventive intervention［J］.Int J Environmental Res Public Health，2014，11(4):3586-3598.
［2］RAJKOVIC N，ZAMAKLAR M，LALIC K，et al.Relationship between obesity，adipocytokines and inflammatory markers in type 2 diabetes：Relevance for cardiovascular risk prevention［J］.Int J Environmental Res Public Health，2014，11(4):4049-4065.
［3］ALONSO R，ANDRES E，MATA N，et al.Lipoprotein(a) Lipoprotein(a) levels in familial hypercholesterolemia：an important predictor of cardiovascular disease independent of the type of LDL receptor mutation［J］.J Am Coll Cardiol，2014，63(19)：1982-1989.
［4］ZAHOOR M，CHA P H，CHOI K Y.Indirubin-3’-oxime，an activator of Wnt/β-catenin signaling，enhances osteogenic commitment of ST2 cells and restores bone loss in high-fat diet-induced obese male mice［J］.Bone，2014，65：60-68.
［5］BARON R，KNEISSEL M.WNT signaling in bone homeostasis and disease：from human mutations to treatments［J］.Nat Med，2013，19(2):179-192.
［6］GONG M L，LIU C G，ZHANG L，et al.Loss of the TNFα function inhibits Wnt/β-catenin signaling，exacerbates obesity development in adolescent spontaneous obese mice［J］.Mol Cell Biochem，2014，391(1-2):59-66.
［7］GUSTAFSON B，SMITH U.Cytokines promote wnt signaling and inflammation and impair the normal differentiation and lipid accumulation in 3T3-L1 preadipocytes［J］.J Biol Chem，2006，281(14):9507-9516.
［8］CHOI H J，LEE D H，JEON H J，et al.Transcription factor 7-like 2 (TCF7L2) gene polymorphism rs7903146 is associated with stroke in type 2 diabetes patients with long disease duration［J］.Diabetes Res Clin Prac，2014，103(3):e3-e6.
［9］SASAKI T，NAKATA R，INOUE H，et al.Role of AMPK and PPARγ1 in exercise-induced lipoprotein lipase in skeletal muscle［J］.Am J Physiol：Endocrinol Metab，2014，306(9):E1085-E1092.
［10］KISFALI P，POLGÁR N，SÁFRÁNY E，et al.Triglyceride level affecting shared susceptibility genes in metabolic syndrome and coronary artery disease［J］.Curr Med Chem，2010，17(30):3533-3541.
［11］FRAZIER-WOOD A C，ORDOVAS J M，STRAKA R J，et al.The PPAR alpha gene is associated with triglyceride，low-density cholesterol and inflammation marker response to fenofibrate intervention：the GOLDN study［J］.Pharmacogenomics J，2013，13(4):312-317.
［12］林婄婄，高中元，乔利英，等.核受体因子PPARγ的研究进展［J］.四川畜牧兽医，2011，(5):32-34.
LIN P P，GAO Z Y，QIAO L Y，et al.Advances of nuclear hormone factor：peroxisome proliferator-actived recepter gamma［J］.Sichuan Animal & Veterinary Sciences,2011，(5):32-34.(in Chinese)
［13］林婄婄，高中元，袁亚男，等.PPARα和PPARγ基因在不同脂尾型绵羊脂肪组织中的发育性表达研究［J］.畜牧兽医学报，2012，43(9):1369-1376.
LIN P P，GAO Z Y，YUAN Y N，et al.Developmental expression of PPARα and PPARγ mRNA in adipose tissues of different fat-tailed sheep［J］.Acta Veterinaria et Zootechnica Sinica，2012，43(9):1369-1376.(in Chinese)
［14］HORNEMANNA T，WORGALLB T S.Sphingolipids and atherosclerosis［J］.Atherosclerosis，2013，226(1):16-28.
［15］ALVAREZ M S，ALVAREZ A F，CUCARELLA C，et al.Stable SREBP-1a knockdown decreases the cell proliferation rate in human preadipocyte cells without inducing senescence［J］.Biochem Biophysical Res Commun，2014，447(1)：51-56.
［16］KARASAWA T，TAKAHASHI A，SAITO R，et al.Sterol regulatory element-binding protein-1 determines plasma remnant lipoproteins and accelerates atherosclerosis in low-density lipoprotein receptor-deficient mice［J］.Arterioscler Thromb Vasc Biol，2011，31:1788-1795.
［17］GOLDSTEIN J L，DEBOSE-BOYD R A，BROWN M S.Protein sensors for membrane sterols［J］.Cell，2006，124(1)：35-46.
［18］BOST F，CARON L，MARCHETTI I,et al.Retinoic acid activation of the ERK pathway is required for embryonic stem cell commitment into the adipocyte lineage［J］.Biochem J，2002，361(3):621-627.
［19］LIAO Q C，LI Y L，QIN Y F，et al.Inhibition of adipocyte differentiation by phytoestrogen genistein through a potential downregulation of extracellular signal-regulated kinases 1/2 activity［J］.J Cell Biochem，2008，104(5):1853-1864.
［20］YANG D C，TSAY H J，LIN S Y，et al.cAMP/PKA regulates osteogenesis，adipogenesis and ratio of RANKL/OPG mRNA expression in mesenchymal stem cells by suppressing leptin［J］.PLoS ONE，2008，3(2):e1540-e1541.
［21］武建亮，乔利英，刘建华，等.绵羊β3肾上腺素能受体基因在脂肪组织中的表达研究［J］.畜牧兽医学报，2012，43(2):196-203.
WU J L，QIAO L Y，LIU J H，et al.Expression of β3-adrenergic recept or gene in ovine adipose tissues［J］.Acta Veterinaria et Zootechnica Sinica，2012，43(2):196-203.(in Chinese)
［22］LI H F，FONG C C，CHEN Y，et al.Beta-adrenergic signals regulate adipogenesis of mouse mesenchymal stem cells via cAMP/PKA pathway［J］.Mol Cell Endocrinol，2010，323(2):201-207.
［23］FONTAINE C，COUSIN W，PLAISANT M，et al.Hedgehog signaling alters adipocyte maturation of human mesenchymal stem cells［J］. Stem Cells，2008，26(4):1037-1046.
［24］CHOI S S，SYN W K，KARACA G F，et al.Leptin promotes the myofibroblastic phenotype in hepatic stellate cells by activating the hedgehog pathway［J］. J Biol Chem，2010，285(47):36551-36560.
［25］LEE R C，FEINBAUM R L，AMBROS V.The C.elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14［J］.Cell，1993，75(5)：843-854.
［26］LI L C，POOKOT D，NOONAN E J，et al.MicroRNA-373 induces expression of genes with complementary promoter sequences［J］.Proc Natl Acad Sci，2008，105(5):1608-1613.
［27］PATEL K，KOLLORY A，TAKASHIMA A，et al.MicroRNA let-7 downregulates STAT3 phosphorylation in pancreatic cancer cells by increasing SOCS3 expression［J］. Cancer Letters，2014，347(1)：54-64.
［28］KAJIMOTO K，NARABA H，IWAI N.MicroRNA and 3T3-L1 pre-adipocyte differentiation［J］.RNA，2006，12(9)：1626-1632.
［29］王乐乐.鸡let-7a的组织表达、功能预测及其靶基因ADIPOR2遗传效应分析［D］.郑州：河南农业大学，2013.
WANG L L.Expression profile and function prediction of chicken miRNA let-7a and genetic variation analysis of target genes ADIPOR2［D］.Zhengzhou：Henan Agricultural University，2013.(in Chinese)
［30］WANG Q，LI Y C，WANG J，et al.miR-17-92 cluster accelerates adipocyte differentiation by negatively regulating tumor-suppressor Rb2/p130［J］. Proc Natl Acad Sci U S A，2008，105(8):2889-2894.
［31］HATA K，NISHIMURA R，IKEDA F，et al.Differential roles of Smad1 and p38 kinase in regulation of peroxisome proliferator-activating receptor c during bone morphogenetic protein 2-induced adipogenesis［J］. Mol Biol Cell，2003，14 (2):545-555.
［32］SUN F，WANG J，PAN Q，et al.Characterization of function and regulation of miR-24-1 and miR-31［J］.Biochem Biophys Res Commun，2009，380(3)：660-665.
［33］CHAN M C，HILYARD A C，WU C，et al.Molecular basis for antagonism between PDGF and the TGFβ family of signalling pathways by control of miR-24 expression［J］.EMBO J，2010，29(3):559-573.
［34］SATOH H,AUDREY NGUYEN M T，KUDOH A，et al.Yacon diet (Smallanthus sonchifolius，Asteraceae) improves hepatic insulin resistance via reducing Trb3 expression in Zucker fa/fa rats［J］.Nutr Diabetes，2013，3(5)：e70.
［35］ESAU C，KANG X，PERALTA E，et al.MicroRNA-143 regulates adipocyte differentiation［J］.J Biol Chem，2004，279(50)：52361-52365.
［36］TAKANABE R，ONO K，ABE Y，et al.Up-regulated expression of microRNA-143 in association with obesity in adipose tissue of mice fed high-fat diet［J］. Biochem Biophys Res Commun，2008，376(4)：728-732.
［37］XIE H M，LIM B，LODISH H F.MicroRNAs induced during adipogenesis that accelerate fat cell development are downregulated in obesity［J］. Diabetes，2009，58(5)：1050-1057.
［38］QIN L M，CHEN Y S，NIU Y N，et al.A deep investigation into the adipogenesis mechanism：Profile of microRNAs regulating adipogenesis by modulating the canonical Wnt/β-catenin signaling pathway［J］.BMC Genomics，2010，11(320)：1-10.
［39］LIANG W C，WANG Y，WAN D C，et al.Characterization of miR-210 in 3T3-L1 adipogenesis［J］.J Cell Biochem，2013，114(12)：2699-2707.
［40］MARTINELLI R，NARDELLI C，PILONE V，et al.miR-519d overexpression is associated with human obesity［J］.Obesity，2010,18(11)：2170-2076.
［41］ROTLLAN N，RAMíREZ C M，ARYAL B，et al.Therapeutic silencing of microRNA-33 inhibits the progression of atherosclerosis in Ldlr^-/- Mice—Brief Report［J］.Arterioscler Thromb Vasc Biol，2013，33(8)：1973-1977.
［42］ZHAO G J，TANG S L，LV Y C，et al.NF-κB suppresses the expression of ATP-binding cassette transporter A1/G1 by regulating SREBP-2 and miR-33a in mice［J］.Int J Cardiol，2014，171(3)：e93-e95.
［43］MEERSON A，TRAURIG M，OSSOWSKI V，et al .Human adipose microRNA-221 is upregulated in obesity and affects fat metabolism downstream of leptin and TNF-α［J］.Diabetologia，2013，56(9):1971-1979.
［44］BROWN P T，SQUIRE M W，LI W J.Characterization and evaluation of mesenchymal stem cells derived from human embryonic stem cells and bone marrow［J］.Cell Tissue Res，2014，358(1)：149-164.
［45］ZHANG Y，XIE R L，STEIN J L，et al.A program of microRNAs controls osteogenic lineage progression by targeting transcription factor Runx2［J］.PNAS，2011，108(24):9863-9868.
［46］DENG Y，WU S，ZHOU H F，et al.Effects of a miR-31，Runx2，and Satb2 regulatory loop on the osteogenic differentiation of bone mesenchymal stem cells［J］.Stem Cell Dev，2013，22(16):2278-2286.
［47］BAGLÌO S R，DEVESCOVI V，GRANCHI D，et al.MicroRNA expression profiling of human bone marrow mesenchymal stem cells during osteogenic differentiation reveals Osterix regulation by miR-31［J］.Gene，2013，527(1):321-331.
［48］TRAJKOVSKI M，HAUSSER J，SOUTSCHEK J，et al.MicroRNAs 103 and 107 regulate insulin sensitivity［J］.Nature，2011，474:649-653.
［49］VINNIKOV I A，HAJDUKIEWICZ K，REYMANN J，et al.Hypothalamic miR-103 protects from hyperphagic obesity in mice［J］.J Neurosci，2014，34(32):10659-10674.
［50］KARBIENER M，FISCHER C，NOWITSCH S，et al.microRNA miR-27b impairs human adipocyte differentiation and targets PPAR［J］. Biochem Biophys Res Commun，2009，390(2)：247-251.
［51］SUN L，TRAJKOVSKIC M.MiR-27 orchestrates the transcriptional regulation of brown adipogenesis［J］.Metabolism，2014，63(2)：272-282.
［52］LEE E K，LEE M J，ABDELMOHSEN K，et al.miR-130 suppresses adipogenesis by inhibiting peroxisome proliferator-activated receptor γ expression［J］.Mol Cell Biol，2011，31(4):626-638.
［53］KIM C，LEE H，CHO Y M，et al.TNFα-induced miR-130 resulted in adipocyte dysfunction during obesity-related inflammation［J］.FEBS Letters，2013，587(23)：3853-3858.
［54］LIZCANO F，VARGAS D.EID1-induces brown-like adipocyte traits in white 3T3-L1 pre-adipocytes［J］.Biochem Biophys Res Commun，2010，398(2)：160-165.
［55］YANG Z，BIAN C J，ZHOU H，et al.Differentiation of human adipose tissue-derived mesenchymal stem cells through adenovirus EID-1［J］.Stem Cell Dev，2011，20(2)：259-267.
［56］HASHMI S，ZHANG J，SIDDIQUI S S，et al.Partner in fat metabolism：role of KLFs in fat burning and reproductive behavior［J］.3 Biotech，2011，1(2):59-72.
［57］MATSUBARA Y，AOKI M，ENDO T，et al.Characterization of the expression profiles of adipogenesis-related factors，ZNF423，KLFs and FGF10，during preadipocyte differentiation and abdominal adipose tissue development in chickens［J］.Comparative Biochemistry and Physiology，Part B，2013，165:189-195.
［58］KINOSHITA M，ONO K，HORIE T，et al.Regulation of adipocyte differentiation by activation of serotonin (5-ht) receptors 5-HT2AR and 5-HT2CR and involvement of microRNA-448-mediated repression of KLF5［J］.Mol Endocrinol，2010，24(10)：1978-1987.
［59］ZHANG W B，ZHONG W J，WANG L.A signal-amplification circuit between miR-218 and Wnt/β-catenin signal promotes human adipose tissue-derived stem cells osteogenic differentiation［J］.Bone，2014，58：59-66.
［60］KAWAKITA A，YANAMOTO S，YAMADA S I，et al.MicroRNA-21 promotes oral cancer invasion via the Wnt/β-Catenin pathway by targeting DKK2［J］.Pathol Oncol Res，2013，20(2):253-261.
［61］MEI Y，BIAN C J，LI J，et al.miR-21 modulates the ERK-MAPK signaling pathway by regulating SPRY2 expression during human mesenchymal stem cell differentiation［J］.J Cell Biochem，2013，114(6):1374-1384.

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Research Progress in Signaling Pathways and microRNA Regulation of Adipocyte Differentiation

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