GPIHBP1分子与血浆中甘油三酯脂蛋白脂解代谢研究进展

doi:10.11843/j.issn.0366-6964.2013.05.001

Abstract

Abstract:

Lipoprotein lipase (LPL) is produced by parenchymal cells from mainly adipocytes and myocytes, but it is involved in hydrolysing triglycerides in plasma lipoproteins at the capillary lumen. For decades, the mechanism by which LPL reaches its site of action in capillaries was unclear, but the problem was recently solved. Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPIHBP1) picks up LPL from the interstitial spaces across endothelial cells to the capillary lumen. When GPIHBP1 is absent, LPL is mislocalized to the interstitial spaces, which lead to severe hypertriglyceridaemia. Some cases of hypertriglyceridaemia in humans are caused by Gpihbp1 mutations that interfere with the ability of GPIHBP1 to bind to LPL. Here, we review recent progress in understanding the role of GPIHBP1 in health and disease and discuss some remaining unresolved issues regarding the processing of triglyceride-rich lipoproteins.

CLC Number:

S813.3

JIANG Yan-zhi, CEN Wang-min, XING Shu-hua, CHEN Jian-ning, LI Xue-wei. New Insights in GPIHBP1 and the Intravascular Processing of Triglyceride-rich Lipoproteins[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2013, 44(5): 665-672.

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New Insights in GPIHBP1 and the Intravascular Processing of Triglyceride-rich Lipoproteins

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