长链非编码RNA——病毒与宿主相互作用中的新型调控因子

doi:10.11843/j.issn.0366-6964.2020.09.003

Abstract

Abstract: Long non-coding RNAs (lncRNAs) are designated as the transcripts longer than 200 nt without protein-coding capacity, which play a crucial role in various biological processes. Current evidence demonstrates that lncRNAs, an important class of novel regulatory RNAs, are induced by viruses and mediate host-virus interactions. They can regulate pathogen recognition receptors and inhibit or activate natural immune responses to feedback viral infections through different mechanisms. In this paper, we focus on the regulation of lncRNAs in virus-host interactions and highlight the regulatory networks of host antiviral responses. This review provides a valuable reference for studying the antiviral effect and mechanism of lncRNAs, and lays the foundation for revealing the pathogenesis mechanism of the virus and discovering new antiviral targets.

Key words: long noncoding RNA, virus, innate immune, pathogen recognition receptor

CLC Number:

Q522
Q527.5

ZHAO Xueliang, LIU Haijin, XIAO Sa, WANG Xinglong, YANG Zengqi. Long Non-coding RNAs: Novel Regulators of Virus-host Interactions[J]. Acta Veterinaria et Zootechnica Sinica, 2020, 51(9): 2059-2067.

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Long Non-coding RNAs: Novel Regulators of Virus-host Interactions

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