Acta Veterinaria et Zootechnica Sinica ›› 2024, Vol. 55 ›› Issue (7): 2846-2858.doi: 10.11843/j.issn.0366-6964.2024.07.007
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Yunfang SONG1,2(), Hao CHENG1,2, Luya FENG1,2, Ping BAI4, Yuankun DENG1,2, Yaoyao XIA3, Bi'e TAN1,2, Jing WANG1,2,*()
Received:
2023-09-28
Online:
2024-07-23
Published:
2024-07-24
Contact:
Jing WANG
E-mail:18084080964@163.com;jingwang023@hunau.edu.cn
CLC Number:
Yunfang SONG, Hao CHENG, Luya FENG, Ping BAI, Yuankun DENG, Yaoyao XIA, Bi'e TAN, Jing WANG. Research Progress on the Mechanism of Nutrition Regulating Intestinal Immune Cell Activation[J]. Acta Veterinaria et Zootechnica Sinica, 2024, 55(7): 2846-2858.
Table 1
Amino acids regulate immune cell fate"
氨基酸及其代谢产物 Amino acids and their metabolites | 免疫细胞 Immune cells | 机制 Mechanism | 亚型和功能 Subtypes and functions |
谷氨酰胺、亮氨酸、甲硫氨酸、精氨酸 Glutamine, leucine, methionine Acid, arginine | T细胞 T cells | 哺乳动物雷帕霉素靶蛋白 mTOR | 活化(+) Activation(+) |
犬尿氨酸 Kynurenine | T细胞 T cells | 芳香烃受体 AhR | 调节性T细胞(+)、辅助性T细胞17(-) Treg(+), Th17(-) |
吲哚乙酸 Indoleacetic acid | T细胞 T cells | 芳香烃受体 AhR | 调节性T细胞(+)、辅助性T细胞17(-) Treg(+),Th17(-) |
硫代半胱氨酸 Thiocysteine | B细胞 B cells | 丙酮酸激酶同工酶2 PKM2 | 活化(+) Activation(+) |
γ-氨基丁酸 GABA | B细胞 B cells | γ-氨基丁酸-γ-氨基丁酸受体-雷帕霉素靶蛋白复合物1 GABA-GABAR-mTORC1 | IgA+ B细胞(+) IgA+ B cells |
色氨酸 Tryptophan | B细胞 B cells | 芳香烃受体 AhR | 调节性B细胞(+)、白介素-10(+) Bregs(+), IL-10(+) |
吲哚乙酸 Indoleacetic acid | B细胞 B cells | Toll样受体4-核因子κB TLR4-NF-κB | 白介素-35(+) IL-35(+) |
丝氨酸 Serine | 巨噬细胞 Macrophage | p38依赖性Janus激酶-信号转导及转录激活蛋白 p38-JAK-STAT | M1巨噬细胞(+)、M2巨噬细胞(-) M1(+), M2(-) |
谷氨酰胺 Glutamine | 巨噬细胞 Macrophage | 核因子κB NF-κB | M1巨噬细胞(-) M1(-) |
Table 2
Fatty acids and carbohydrates regulate the fate of immune cells"
分类 Sort | 营养代谢 Nutrient metabolism | 免疫细胞 Immune cells | 机制 Mechanism | 亚型和功能 Subtypes and functions |
脂肪酸 Fatty acid | 脂肪酸 Fatty acid | T细胞 T cells | G蛋白偶联受体120-转化生长因子β激活激酶1- IκB激酶-核因子κB GPR120-TAK1-IKK-NF-κB | 活化(-) Activation(-) |
二十碳五烯酸、二十二碳六烯酸 EPA、DHA | 白细胞介素-6/糖蛋白130-信号转导子和转录激活子3 IL-6/gp130-STAT3 | 辅助性T细胞17(-) Th17(-) | ||
单糖 Monose | 果糖 Fructose | 巨噬细胞 Macrophage | Toll样受体4-丝裂原活化蛋白激酶/核因子κb/Janus激酶3-信号转导子和转录激活子4 TLR4- MAPK/NF-κB/JAK3-STAT4 | 白细胞介素-6、肿瘤坏死因子-α IL-6、TNF-α |
葡萄糖 Glucose | T细胞 T cells | 活性氧-转化生长因子-β-受体反应性 ROS-TGF-β-ROR | 辅助性T细胞17(+) Th17(+) | |
B细胞 B cells | 哺乳动物雷帕霉素靶蛋白 mTOR | 凋亡(+) Apoptosis(+) | ||
巨噬细胞 Macrophage | Toll样受体4-核因子κb/丝裂原活化蛋白激酶 TLR4-NF-κB/MAPK | 白细胞介素-6、白细胞介素-1β、肿瘤坏死因子-α(+) IL-6、IL-1β、TNF-α(+) | ||
多糖 Polysaccharide | 岩藻聚糖 Fucosan | 巨噬细胞 Macrophage | 诱导型一氧化氮合酶-环氧化酶2 iNOS-COX-2 | 白细胞介素-6、白细胞介素-1β、肿瘤坏死因子-α(-) IL-6、IL-1β、TNF-α(-) |
多糖 Polysaccharide | 茯苓多糖 Pachymaran | 巨噬细胞 Macrophage | Toll样受体4-髓样分化因子88/肿瘤坏死因子受体相关因子6 TLR4-MyD88/TRAF6 | 白细胞介素-2、白细胞介素-6、白细胞介素-17A、肿瘤坏死因子-α、干扰素-γ(+) IL-2、IL-6、IL-17A、TNF-α、IFN-γ(+) |
果胶 Pectin | 巨噬细胞 Macrophage | Toll样受体2 TLR2 | 肿瘤坏死因子-α、干扰素-γ、 白细胞介素-17(+) TNF-α、IFN-γ、IL-17(+) | |
白细胞介素-22-芳香烃受体-白细胞介素-3 IL-22-AhR-IL-3 | 白细胞介素-10、白细胞介素-1β、白细胞介素-6、白细胞介素-8、肿瘤坏死因子-α(-) IL-10、IL-1β、IL-6、IL-8、TNF-α(-) | |||
短链脂肪酸 SCFAs | 短链脂肪酸 SCFAs | T细胞 T cells | G蛋白偶联受体43 GPR43 | 辅助性T细胞1、白细胞介素-10(+) Th1;IL-10(+) |
乙酸盐 Acetate | 蛋白激酶S6K/核糖体S6蛋白-哺乳动物雷帕霉素靶蛋白-G蛋白偶联受体41/43 S6K/rS6-mTOR-GPR41/GPR43 | 辅助性T细胞1、辅助性T细胞17、白细胞介素-10(+) Th1、Th17;IL-10(+) | ||
丙酸盐 Propionate | G蛋白偶联受体6/组蛋白脱乙酰酶 G protein-coupled receptor 6/histone deacetylase | 辅助性T细胞17、调节性T细胞(+) Th17、Tregs(+) | ||
丁酸盐 Butyrate | B细胞 B cells | 芳香烃受体 AhR | 调节性B细胞(+) Breg(+) 白细胞介素-10(+),白细胞介素-17(-) IL-10(+),IL-17(-) | |
视黄酸受体 RAR | 白细胞介素-10(+),白细胞介素-17(-) IL-10(+),IL-17(-) | |||
巨噬细胞 Macrophage | 核苷酸结合寡聚蛋白3 NLRP3 | 活化(-); Activation(-) |
Table 3
Micronutrients regulate immune cell fate"
营养素 Nutrient | 免疫细胞 Immune cell | 亚型和功能 Subtypes and functions |
锌 Zinc | T细胞 T cells | 辅助性T细胞1(+)、辅助性T细胞17(-)、调节性T细胞(-) Th1(+),Th17(-),Tregs(-) |
B细胞 B cells | 成熟(+)、凋亡(-) Maturation(+),apoptosis(-) | |
硒 Selenium | T细胞 T cells | 辅助性T细胞1、白细胞介素-12p40、干扰素-γ(+) Th 1,IL-12p40,IFN-γ(+) |
巨噬细胞 Macrophage | M1巨噬细胞、白细胞介素-10(-) M1,IL-10(-) | |
铁 Iron | 巨噬细胞 Macrophage | M1巨噬细胞 M1(-) |
T细胞 T cells | 调节性T细胞(-) Tregs(-) | |
B细胞 B cells | 增殖、浆细胞(+) Proliferating, plasma cells(+) | |
维生素E Vitamin E | T细胞 T cells | 白细胞介素-2/10、肿瘤坏死因子-α、干扰素-γ(+) IL-2,IL-10,TNF-α,IFN-γ(+) |
维生素C Vitamin C | T细胞 T cells | 增殖(+) Proliferating(+) |
维生素C Vitamin C | B细胞 B cells | 成熟(+) Maturation(+) |
维生素B Vitamin B | 树突细胞 Dendritic cell | 白细胞介素-6/12/1β、肿瘤坏死因子-α(+) IL-6,IL-12,IL-1β,TNF-α(+) |
T细胞 T cells | 白细胞介素-4/5/9/13/17/33(-) IL-4,IL-5,IL-9,IL-13,IL-17,IL-33(-) | |
巨噬细胞 Macrophage | M2巨噬细胞(+) M2(+) | |
维生素A Vitamin A | T细胞 T cells | 调节性T细胞、辅助性T细胞17、白细胞介素-6(+),辅助性T细胞2(-) Tregs,Th17,IL-6(+),Th2(-) |
巨噬细胞 Macrophage | M1巨噬细胞(+) M1(+) | |
维生素D Vitamin D | 巨噬细胞 Macrophage | M2巨噬细胞、白细胞介素-10(+),肿瘤坏死因子-α(-) M2,IL-10(+),TNF-α(-) |
1 |
SANIDAD K Z , ZENG M Y . Neonatal gut microbiome and immunity[J]. Curr Opin Microbiol, 2020, 56, 30- 37.
doi: 10.1016/j.mib.2020.05.011 |
2 |
CHASE C C L . Enteric immunity: happy gut, healthy animal[J]. Vet Clin North Am Food Anim Pract, 2018, 34 (1): 1- 18.
doi: 10.1016/j.cvfa.2017.10.006 |
3 |
ADILIAGHDAM F , AMATULLAH H , DIGUMARTHI S , et al. Human enteric viruses autonomously shape inflammatory bowel disease phenotype through divergent innate immunomodulation[J]. Sci Immunol, 2022, 7 (70): eabn6660.
doi: 10.1126/sciimmunol.abn6660 |
4 |
LIAO Y , ZHAO J J , BULEK K , et al. Inflammation mobilizes copper metabolism to promote colon tumorigenesis via an IL-17-STEAP4-XIAP axis[J]. Nat Commun, 2020, 11 (1): 900.
doi: 10.1038/s41467-020-14698-y |
5 |
SHEN Q C , HUANG Z Z , YAO J C , et al. Extracellular vesicles-mediated interaction within intestinal microenvironment in inflammatory bowel disease[J]. J Adv Res, 2022, 37, 221- 233.
doi: 10.1016/j.jare.2021.07.002 |
6 |
STOCKINGER B , SHAH K , WINCENT E . AHR in the intestinal microenvironment: safeguarding barrier function[J]. Nat Rev Gastroenterol Hepatol, 2021, 18 (8): 559- 570.
doi: 10.1038/s41575-021-00430-8 |
7 |
MUCIDA D , ESTERHAZY D . SnapShot: gut immune niches[J]. Cell, 2018, 174 (6): 1600- 1600.e1.
doi: 10.1016/j.cell.2018.08.043 |
8 |
PEREZ-LOPEZ A , BEHNSEN J , NUCCIO S P , et al. Mucosal immunity to pathogenic intestinal bacteria[J]. Nat Rev Immunol, 2016, 16 (3): 135- 148.
doi: 10.1038/nri.2015.17 |
9 |
CANESSO M C C , MOREIRA T G , FARIA A M C . Compartmentalization of gut immune responses: mucosal niches and lymph node peculiarities[J]. Immunol Lett, 2022, 251-252, 86- 90.
doi: 10.1016/j.imlet.2022.10.005 |
10 |
JAMES K R , GOMES T , ELMENTAITE R , et al. Distinct microbial and immune niches of the human colon[J]. Nat Immunol, 2020, 21 (3): 343- 353.
doi: 10.1038/s41590-020-0602-z |
11 |
COSTA G T , VASCONCELOS Q D J S , ARAGÃO G F . Fructooligosaccharides on inflammation, immunomodulation, oxidative stress, and gut immune response: a systematic review[J]. Nutr Rev, 2022, 80 (4): 709- 722.
doi: 10.1093/nutrit/nuab115 |
12 |
MACPHERSON A J , HARRIS N L . Interactions between commensal intestinal bacteria and the immune system[J]. Nat Rev Immunol, 2004, 4 (6): 478- 485.
doi: 10.1038/nri1373 |
13 |
KAYAMA H , OKUMURA R , TAKEDA K . Interaction between the microbiota, epithelia, and immune cells in the intestine[J]. Annu Rev Immunol, 2020, 38, 23- 48.
doi: 10.1146/annurev-immunol-070119-115104 |
14 |
FANG P , LI X Y , DAI J , et al. Immune cell subset differentiation and tissue inflammation[J]. J Hematol Oncol, 2018, 11 (1): 97.
doi: 10.1186/s13045-018-0637-x |
15 |
WILLIAMS J A , ZHANG J J , JEON H , et al. Thymic medullary epithelium and thymocyte self-tolerance require cooperation between CD28-CD80/86 and CD40-CD40L costimulatory pathways[J]. J Immunol, 2014, 192 (2): 630- 640.
doi: 10.4049/jimmunol.1302550 |
16 |
TANG T T , CHENG X , TRUONG B , et al. Molecular basis and therapeutic implications of CD40/CD40L immune checkpoint[J]. Pharmacol Ther, 2021, 219, 107709.
doi: 10.1016/j.pharmthera.2020.107709 |
17 |
MØLLER S H , HSUEH P C , YU Y R , et al. Metabolic programs tailor T cell immunity in viral infection, cancer, and aging[J]. Cell Metab, 2022, 34 (3): 378- 395.
doi: 10.1016/j.cmet.2022.02.003 |
18 |
HAN C F , GE M M , HO P C , et al. Fueling T-cell antitumor immunity: amino acid metabolism revisited[J]. Cancer Immunol Res, 2021, 9 (12): 1373- 1382.
doi: 10.1158/2326-6066.CIR-21-0459 |
19 |
XIA Y Y , CHEN S Y , ZHAO Y Y , et al. GABA attenuates ETEC-induced intestinal epithelial cell apoptosis involving GABAAR signaling and the AMPK-autophagy pathway[J]. Food Funct, 2019, 10 (11): 7509- 7522.
doi: 10.1039/C9FO01863H |
20 |
LI M X , LI M Y , LEI J X , et al. Huangqin decoction ameliorates DSS-induced ulcerative colitis: role of gut microbiota and amino acid metabolism, mTOR pathway and intestinal epithelial barrier[J]. Phytomedicine, 2022, 100, 154052.
doi: 10.1016/j.phymed.2022.154052 |
21 |
CHENG H , LIU J , ZHANG D D , et al. Ginsenoside Rg1 alleviates acute ulcerative colitis by modulating gut microbiota and microbial tryptophan metabolism[J]. Front Immunol, 2022, 13, 817600.
doi: 10.3389/fimmu.2022.817600 |
22 |
OPITZ C A , LITZENBURGER U M , SAHM F , et al. An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor[J]. Nature, 2011, 478 (7368): 197- 203.
doi: 10.1038/nature10491 |
23 |
WANG J J , ZHU N N , SU X M , et al. Gut-microbiota-derived metabolites maintain gut and systemic immune homeostasis[J]. Cells, 2023, 12 (5): 793.
doi: 10.3390/cells12050793 |
24 |
WANG X Y , SUN G Q , FENG T , et al. Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer's disease progression[J]. Cell Res, 2019, 29 (10): 787- 803.
doi: 10.1038/s41422-019-0216-x |
25 |
KELLY B , PEARCE E L . Amino assets: how amino acids support immunity[J]. Cell Metab, 2020, 32 (2): 154- 175.
doi: 10.1016/j.cmet.2020.06.010 |
26 | WU B , LI L , RUAN T , et al. Effect of methionine deficiency on duodenal and jejunal IgA+ B cell count and immunoglobulin level of broilers[J]. Iran J Vet Res, 2018, 19 (3): 165- 171. |
27 |
DENG J , LÜ S , LIU H Y , et al. Homocysteine activates B cells via regulating PKM2-dependent metabolic reprogramming[J]. J Immunol, 2017, 198 (1): 170- 183.
doi: 10.4049/jimmunol.1600613 |
28 |
LIAO Y X , FAN L J , BIN P , et al. GABA signaling enforces intestinal germinal center B cell differentiation[J]. Proc Natl Acad Sci U S A, 2022, 119 (44): e2215921119.
doi: 10.1073/pnas.2215921119 |
29 |
SU X M , GAO Y H , YANG R C . Gut microbiota-derived tryptophan metabolites maintain gut and systemic homeostasis[J]. Cells, 2022, 11 (15): 2296.
doi: 10.3390/cells11152296 |
30 |
ZHUANG H R , YANG Z H , CHEN T H , et al. Boosting HSA vaccination with jujube powder modulating gut microbiota favorable for arginine metabolism[J]. Nutrients, 2023, 15 (8): 1955.
doi: 10.3390/nu15081955 |
31 |
SHAN X , HU P H , NI L N , et al. Serine metabolism orchestrates macrophage polarization by regulating the IGF1-p38 axis[J]. Cell Mol Immunol, 2022, 19 (11): 1263- 1278.
doi: 10.1038/s41423-022-00925-7 |
32 |
XIA Y Y , HE F , WU X Y , et al. GABA transporter sustains IL-1β production in macrophages[J]. Sci Adv, 2021, 7, eabe9274.
doi: 10.1126/sciadv.abe9274 |
33 |
HU X B , MA Z F , XU B B , et al. Glutamine metabolic microenvironment drives M2 macrophage polarization to mediate trastuzumab resistance in HER2-positive gastric cancer[J]. Cancer Commun (Lond), 2023, 43 (8): 909- 937.
doi: 10.1002/cac2.12459 |
34 |
MATOS A , CARVALHO M , BICHO M , et al. Arginine and arginases modulate metabolism, tumor microenvironment and prostate cancer progression[J]. Nutrients, 2021, 13 (12): 4503.
doi: 10.3390/nu13124503 |
35 |
ZHAO Y M , SUN J X , LI Y , et al. Tryptophan 2, 3-dioxygenase 2 controls M2 macrophages polarization to promote esophageal squamous cell carcinoma progression via AKT/GSK3β/IL-8 signaling pathway[J]. Acta Pharm Sin B, 2021, 11 (9): 2835- 2849.
doi: 10.1016/j.apsb.2021.03.009 |
36 |
FRANCESCHI T S , SOARES M S P , PEDRA N S , et al. Characterization of macrophage phenotype, redox, and purinergic response upon chronic treatment with methionine and methionine sulfoxide in mice[J]. Amino Acids, 2020, 52 (4): 629- 638.
doi: 10.1007/s00726-020-02841-4 |
37 | KIM Y J , LEE J Y , LEE J J , et al. Arginine-mediated gut microbiome remodeling promotes host pulmonary immune defense against nontuberculous mycobacterial infection[J]. Gut Microbes, 2022, 14 (1): 2073132. |
38 |
DRAPER E , DECOURCEY J , HIGGINS S C , et al. Conjugated linoleic acid suppresses dendritic cell activation and subsequent Th17 responses[J]. J Nutr Biochem, 2014, 25 (7): 741- 749.
doi: 10.1016/j.jnutbio.2014.03.004 |
39 |
CALDER P C . Immunomodulation by omega-3 fatty acids[J]. Prostaglandins Leukot Essent Fatty Acids, 2007, 77 (5-6): 327- 335.
doi: 10.1016/j.plefa.2007.10.015 |
40 |
CARLSSON J A , WOLD A E , SANDBERG A S , et al. The polyunsaturated fatty acids arachidonic acid and docosahexaenoic acid induce mouse dendritic cells maturation but reduce T-cell responses in vitro[J]. PLoS One, 2015, 10 (11): e0143741.
doi: 10.1371/journal.pone.0143741 |
41 |
HOU T Y , MCMURRAY D N , CHAPKIN R S . Omega-3 fatty acids, lipid rafts, and T cell signaling[J]. Eur J Pharmacol, 2016, 785, 2- 9.
doi: 10.1016/j.ejphar.2015.03.091 |
42 |
OUYANG L , DAN Y , HUA W B , et al. Therapeutic effect of omega-3 fatty acids on T cell-mediated autoimmune diseases[J]. Microbiol Immunol, 2020, 64 (8): 563- 569.
doi: 10.1111/1348-0421.12800 |
43 |
LAUSON C B N , TIBERTI S , CORSETTO P A , et al. Linoleic acid potentiates CD8+ Tcell metabolic fitness and antitumor immunity[J]. Cell Metab, 2023, 35 (4): 633- 650.e9.
doi: 10.1016/j.cmet.2023.02.013 |
44 | LIERMANN W , VIERGUTZ T , UKEN K L , et al. Influences of maternal conjugated linoleic acid and essential fatty acid supply during late pregnancy and early lactation on T and B cell subsets in mesenteric lymph nodes and the small intestine of neonatal calves[J]. Front Vet Sci, 2020, 16 (7): 604452. |
45 | HUBLER M J , KENNEDY A J . Role of lipids in the metabolism and activation of immune cells[J]. J Nutr Biochem, 2015, 34, 1- 7. |
46 |
YANG S S , WANG C J , HUANG X , et al. Linoleic acid stimulation results in TGF-β1 production and inhibition of PEDV infection in vitro[J]. Virology, 2023, 581, 89- 91.
doi: 10.1016/j.virol.2023.03.004 |
47 |
ROCKETT B D , SALAMEH M , CARRAWAY K , et al. n-3 PUFA improves fatty acid composition, prevents palmitate-induced apoptosis, and differentially modifies B cell cytokine secretion in vitro and ex vivo[J]. J Lipid Res, 2010, 51 (6): 1284- 1297.
doi: 10.1194/jlr.M000851 |
48 |
DRAPER E , REYNOLDS C M , CANAVAN M , et al. Omega-3 fatty acids attenuate dendritic cell function via NF-κB independent of PPARγ[J]. J Nutr Biochem, 2011, 22 (8): 784- 790.
doi: 10.1016/j.jnutbio.2010.06.009 |
49 |
KONG W M , YEN J H , GANEA D . Docosahexaenoic acid prevents dendritic cell maturation, inhibits antigen-specific Th1/Th17 differentiation and suppresses experimental autoimmune encephalomyelitis[J]. Brain, Behav, Immun, 2011, 25 (5): 872- 882.
doi: 10.1016/j.bbi.2010.09.012 |
50 |
LOSCHER C E , DRAPER E , LEAVY O , et al. Conjugated linoleic acid suppresses NF-κB activation and IL-12 production in dendritic cells through ERK-mediated IL-10 induction[J]. J Immunol, 2005, 175 (8): 4990- 4998.
doi: 10.4049/jimmunol.175.8.4990 |
51 |
CHENG H , ZHOU J Y , SUN Y T , et al. High fructose diet: a risk factor for immune system dysregulation[J]. Hum Immunol, 2022, 83 (6): 538- 546.
doi: 10.1016/j.humimm.2022.03.007 |
52 | MA X , NAN F , LIANG H T , et al. Excessive intake of sugar: an accomplice of inflammation[J]. Front Immunol, 2022, 13 (13): 988481. |
53 |
XIA Y Y , ZHANG Q Z , YE Y Y , et al. Melatonergic signalling instructs transcriptional inhibition of IFNGR2 to lessen interleukin-1β-dependent inflammation[J]. Clin Translational Med, 2022, 12 (2): e716.
doi: 10.1002/ctm2.716 |
54 |
JAYAWARDENA T U , SANJEEWA K K A , NAGAHAWATTA D P , et al. Anti-inflammatory effects of sulfated polysaccharide from Sargassum swartzii in macrophages via blocking TLR/NF-Κb Signal Transduction[J]. Mar Drugs, 2020, 18 (12): 601.
doi: 10.3390/md18120601 |
55 |
陆江, 朱道仙, 卢劲晔, 等. 高聚合度菊粉通过调节肠-脂肪组织轴改善高脂饮食诱导的犬肥胖[J]. 畜牧兽医学报, 2023, 54 (9): 3941- 3950.
doi: 10.11843/j.issn.0366-6964.2023.09.032 |
LU J , ZHU D X , LU J Y , et al. Inulin with high degree of polymerization improves high-fat diet induced obesity in dogs by regulating the gut-adipose tissue axis[J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54 (9): 3941- 3950.
doi: 10.11843/j.issn.0366-6964.2023.09.032 |
|
56 |
JAYACHANDRAN M , CHEN J L , CHUNG S S M , et al. A critical review on the impacts of β-glucans on gut microbiota and human health[J]. J Nutr Biochem, 2018, 61, 101- 110.
doi: 10.1016/j.jnutbio.2018.06.010 |
57 |
TIAN H , LIU Z J , PU Y W , et al. Immunomodulatory effects exerted by Poria Cocos polysaccharides via TLR4/TRAF6/NF-κB signaling in vitro and in vivo[J]. Biomed Pharmacother, 2019, 112, 108709.
doi: 10.1016/j.biopha.2019.108709 |
58 |
DANG G Q , WEN X B , ZHONG R Q , et al. Pectin modulates intestinal immunity in a pig model via regulating the gut microbiota-derived tryptophan metabolite-AhR-IL22 pathway[J]. J Anim Sci Biotechnol, 2023, 14 (1): 38.
doi: 10.1186/s40104-023-00838-z |
59 |
BLANCO-PÉREZ F , STEIGERWALD H , SCHÜLKE S , et al. The dietary fiber pectin: health benefits and potential for the treatment of allergies by modulation of gut microbiota[J]. Curr Allergy Asthma Rep, 2021, 21 (10): 43.
doi: 10.1007/s11882-021-01020-z |
60 |
TIAN S S , PAUDEL D , HAO F H , et al. Refined fiber inulin promotes inflammation-associated colon tumorigenesis by modulating microbial succinate production[J]. Cancer Rep (Hoboken), 2023, 6 (11): e1863.
doi: 10.1002/cnr2.1863 |
61 | OSTADMOHAMMADI S , NOJOUMI S A , FATEH A , et al. Interaction between Clostridium species and microbiota to progress immune regulation[J]. Acta Microbiol Immunol Hung, 2022, 7, 01678. |
62 |
DU H X , YUE S Y , NIU D , et al. Gut microflora modulates Th17/Treg cell differentiation in experimental autoimmune prostatitis via the short-chain fatty acid propionate[J]. Front Immunol, 2022, 13, 915218.
doi: 10.3389/fimmu.2022.915218 |
63 |
PARK J , KIM M , KANG S G , et al. Short-chain fatty acids induce both effector and regulatory T cells by suppression of histone deacetylases and regulation of the mTOR-S6K pathway[J]. Mucosal Immunol, 2015, 8 (1): 80- 93.
doi: 10.1038/mi.2014.44 |
64 |
HE F , QIU Y Y , WU X Y , et al. Slc6a13 deficiency attenuates Pasteurella multocida infection-induced inflammation via glycine-inflammasome signaling[J]. J Innate Immun, 2023, 15 (1): 107- 121.
doi: 10.1159/000525089 |
65 |
KIM M , QIE Y , PARK J , et al. Gut microbial metabolites fuel host antibody responses[J]. Cell Host Microbe, 2016, 20 (2): 202- 214.
doi: 10.1016/j.chom.2016.07.001 |
66 |
ROSSER E C , PIPER C J M , MATEI D E , et al. Microbiota-derived metabolites suppress arthritis by amplifying aryl-hydrocarbon receptor activation in regulatory B cells[J]. Cell Metab, 2020, 31 (4): 837- 851.e10.
doi: 10.1016/j.cmet.2020.03.003 |
67 |
KIM D S , WOO J S , MIN H K , et al. Short-chain fatty acid butyrate induces IL-10-producing B cells by regulating circadian-clock-related genes to ameliorate Sjögren's syndrome[J]. J Autoimmun, 2021, 119, 102611.
doi: 10.1016/j.jaut.2021.102611 |
68 |
ELMADFA I , MEYER A L . The role of the status of selected micronutrients in shaping the immune function[J]. Endocr Metab Immune Disord Drug Targets, 2019, 19 (8): 1100- 1115.
doi: 10.2174/1871530319666190529101816 |
69 |
FAN L J , XIA Y Y , WANG Y X , et al. Gut microbiota bridges dietary nutrients and host immunity[J]. Sci China Life Sci, 2023, 66 (11): 2466- 2514.
doi: 10.1007/s11427-023-2346-1 |
70 |
XIA Y Y , CHEN S Y , ZENG S J , et al. Melatonin in macrophage biology: current understanding and future perspectives[J]. J Pineal Res, 2019, 66 (2): e12547.
doi: 10.1111/jpi.12547 |
71 |
GARCÍA-MONTERO C , FRAILE-MARTÍNEZ O , GÓMEZ-LAHOZ A M , et al. Nutritional components in western diet versus mediterranean diet at the gut microbiota-immune system interplay.implications for health and disease[J]. Nutrients, 2021, 13 (2): 699.
doi: 10.3390/nu13020699 |
72 |
PARADA VENEGAS D , DE LA FUENTE M K , LANDSKRON G , et al. Short Chain Fatty Acids (SCFAs)-mediated gut epithelial and immune regulation and its relevance for inflammatory bowel diseases[J]. Front Immunol, 2019, 10, 277.
doi: 10.3389/fimmu.2019.00277 |
73 |
KHAN S , WALIULLAH S , GODFREY V , et al. Dietary simple sugars alter microbial ecology in the gut and promote colitis in mice[J]. Sci Transl Med, 2020, 12 (567): eaay6218.
doi: 10.1126/scitranslmed.aay6218 |
74 |
HOCHREIN S M , WU H , ECKSTEIN M , et al. The glucose transporter GLUT3 controls T helper 17 cell responses through glycolytic-epigenetic reprogramming[J]. Cell Metab, 2022, 34 (4): 516- 532.e11.
doi: 10.1016/j.cmet.2022.02.015 |
75 |
田威龙, 司景磊, 刘笑笑, 等. 高脂高糖饮食对小型猪肠道微生物的影响[J]. 畜牧兽医学报, 2022, 53 (4): 1143- 1153.
doi: 10.11843/j.issn.0366-6964.2022.04.014 |
TIAN W L , SI J L , LIU X X , et al. Effects of high-fat and high-sugar diet on intestinal microbiota in mini-pigs[J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53 (4): 1143- 1153.
doi: 10.11843/j.issn.0366-6964.2022.04.014 |
|
76 |
KAWANO Y , EDWARDS M , HUANG Y M , et al. Microbiota imbalance induced by dietary sugar disrupts immune-mediated protection from metabolic syndrome[J]. Cell, 2022, 185 (19): 3501- 3519.e20.
doi: 10.1016/j.cell.2022.08.005 |
77 |
BARREA L , MUSCOGIURI G , FRIAS-TORAL E , et al. Nutrition and immune system: from the Mediterranean diet to dietary supplementary through the microbiota[J]. Crit Rev Food Sci Nutr, 2021, 61 (18): 3066- 3090.
doi: 10.1080/10408398.2020.1792826 |
78 |
HASKEY N , ESTAKI M , YE J Y , et al. A Mediterranean Diet Pattern improves intestinal inflammation concomitant with reshaping of the bacteriome in ulcerative colitis: a randomized controlled trial[J]. J Crohns Colitis, 2023, 17 (10): 1569- 1578.
doi: 10.1093/ecco-jcc/jjad073 |
79 |
MERRA G , NOCE A , MARRONE G , et al. Influence of mediterranean diet on human gut microbiota[J]. Nutrients, 2020, 13 (1): 7.
doi: 10.3390/nu13010007 |
80 | MAKKI K , DEEHAN E C , WALTER J , et al. The impact of dietary fiber on gut microbiota in host health and disease[J]. Cell Host Microbe, 2018, 23 (6): 705- 715. |
81 | ZHAO L P , ZHANG F , DING X Y , et al. Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes[J]. Science, 2018, 359 (6380): 1151- 1156. |
82 | MATSUMOTO K , SAWANO H , OTSUBO M , et al. Comparison of the Effects of 3 Forms of Soluble Dietary Fiber on the Production of IgA in BALB/cAJcl and BALB/cAJcl-nu/nu Mice[J]. J Nutr, 2023, 153 (5): 1618- 1626. |
83 | XIA Y Y , DING X Z , WANG S Y , et al. Circadian orchestration of host and gut microbiota in infection[J]. Biol Rev, 2023, 98 (1): 115- 131. |
84 | MICHAUDEL C , SOKOL H . The gut microbiota at the service of immunometabolism[J]. Cell Metab, 2020, 32 (4): 514- 523. |
85 | ESLAMI M , YOUSEFI B , KOKHAEI P , et al. Importance of probiotics in the prevention and treatment of colorectal cancer[J]. J Cell Physiol, 2019, 234 (10): 17127- 17143. |
86 | PLAZA-DIAZ J , RUIZ-OJEDA F J , GIL-CAMPOS M , et al. Mechanisms of action of probiotics[J]. Adv Nutr, 2019, 10, S49- S66. |
87 | BATTISTINI C , B R , HERKENHOFF M E , et al. Vitamin D modulates intestinal microbiota in inflammatory bowel diseases[J]. Int J Mol Sciences, 2020, 22 (1): 362. |
88 | FIERS W D , LEONARDI I , ILIEV I D . From birth and throughout life: fungal microbiota in nutrition and metabolic health[J]. Annu Rev Nutr, 2020, 40, 323- 343. |
89 | MALIK A , SHARMA D , MALIREDDI R K S , et al. SYK-CARD9 signaling axis promotes gut fungi-mediated inflammasome activation to restrict colitis and colon cancer[J]. Immunity, 2018, 49 (3): 515- 530.e5. |
90 | ZHU Y N , SHI T , LU X , et al. Fungal-induced glycolysis in macrophages promotes colon cancer by enhancing innate lymphoid cell secretion of IL-22[J]. EMBO J, 2021, 40 (11): e105320. |
91 | BÄR E , WHITNEY P G , MOOR K , et al. IL-17 regulates systemic fungal immunity by controlling the functional competence of NK cells[J]. Immunity, 2014, 40 (1): 117- 127. |
92 | NAGATA N , TAKEUCHI T , MASUOKA H , et al. Human gut microbiota and its metabolites impact immune responses in COVID-19 and its complications[J]. Gastroenterology, 2023, 164 (2): 272- 288. |
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