Abstract: Under the intensive farming mode, early weaning has become an important measure to promote the development of herbivorous animal husbandry. Studies on humans and other animals have shown that early life stress could lead to many negative consequences, including serious mental disorders, such as depression, anxiety and other mental diseases. Intestinal flora regulates host behavior through brain-gut axis. Inoculation of probiotics can improve the abnormal behavior of the offspring. This paper systematically introduces the influence of early maternal separation on behavior of offspring, and the effects of intestinal flora structure improvement on offspring’s behavior and its mechanism. In order to provide a reference basis for further understanding the impact of early weaning on the behavior of offspring and improving the abnormal behavior of offspring caused by early weaning.

Key words: maternal separation, abnormal behavior, brain-gut axis, intestinal flora