Acta Veterinaria et Zootechnica Sinica ›› 2022, Vol. 53 ›› Issue (5): 1334-1344.doi: 10.11843/j.issn.0366-6964.2022.05.002
• REVIEW • Previous Articles Next Articles
ZHANG Deming, HUANG Jiahe, LI Jinshu, ZHENG Hongmei, WANG Shaoying, YANG Gongshe, SHI Xin’e*
Received:
2021-08-09
Online:
2022-05-23
Published:
2022-05-25
CLC Number:
ZHANG Deming, HUANG Jiahe, LI Jinshu, ZHENG Hongmei, WANG Shaoying, YANG Gongshe, SHI Xin’e. Research Progress of Gut Microbiota, Metabolites and Gut Barrier in Pigs[J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53(5): 1334-1344.
[1] | 刘作华,杜 蕾,齐仁立.仔猪早期肠道微生物变化特点及饲养管理措施[J].饲料工业,2020,41(19):5-11.LIU Z H,DU L,QI R L.The dynamic changes of gut microbiota and feed managements in piglets at early life[J].Feed Industry,2020,41(19):5-11.(in Chinese) |
[2] | JIANG L L,FENG C P,TAO S Y,et al.Maternal imprinting of the neonatal microbiota colonization in intrauterine growth restricted piglets:a review[J].J Anim Sci Biotechnol,2019,10:88. |
[3] | 孙笑非,孙冬岩,王文娟,等.猪肠道微生物定植规律和生理功能[J].饲料研究,2011(9):70-72.SUN X F,SUN D Y,WANG W J,et al.Colonization and physiological function of intestinal microorganisms in pigs[J].Feed Research,2011(9):70-72.(in Chinese) |
[4] | HUANG S M,LI N,LIU C,et al.Characteristics of the gut microbiota colonization,inflammatory profile,and plasma metabolome in intrauterine growth restricted piglets during the first 12 hours after birth[J].J Microbiol,2019,57(9):748-758. |
[5] | LI N,HUANG S M,JIANG L L,et al.Differences in the gut microbiota establishment and metabolome characteristics between low- and normal-birth-weight piglets during early-life[J].Front Microbiol,2018,9:1798. |
[6] | PLUSKE J R,LE DIVIDICH J,VERSTEGEN M W A.Weaning the pig:concepts and consequences[M].Netherlands:Wageningen Pers,2003. |
[7] | 张柏林,秦贵信,孙泽威,等.仔猪胃肠道微生物菌群定植规律及其功能的研究进展[J].中国畜牧杂志,2009,45(19):66-69.ZHANG B L,QIN G X,SUN Z W,et al.Advances in gastrointestinal microflora colonization rule and function of piglet[J].Chinese Journal of Animal Science,2009,45(19):66-69.(in Chinese) |
[8] | 王怀禹.猪肠道微生物菌群特征与营养调控[J].猪业科学,2020,37(9):62-65.WANG H Y.Characteristics and nutritional regulation of intestinal microflora in pigs[J].Swine Industry Science,2020,37(9):62-65.(in Chinese) |
[9] | 王文文,王 园,安晓萍,等.断奶仔猪肠道菌群结构特征及其调控研究进展[J].动物营养学报,2020,32(11):4998-5005.WANG W W,WANG Y,AN X P,et al.Research advances on structural characteristics and modulation of gut Microbiota of weaned piglets[J].Chinese Journal of Animal Nutrition,2020,32(11):4998-5005.(in Chinese) |
[10] | PAJARILLO E A B,CHAE J P,BALOLONG M P,et al.Assessment of fecal bacterial diversity among healthy piglets during the weaning transition[J].J General Appl Microbiol,2014,60(4):140-146. |
[11] | ARFKEN A M,FREY J F,SUMMERS K L.Temporal dynamics of the gut bacteriome and mycobiome in the weanling pig[J].Microorganisms,2020,8(6):868. |
[12] | LU D,TIEZZI F,SCHILLEBEECKX C,et al.Host contributes to longitudinal diversity of fecal microbiota in swine selected for lean growth[J].Microbiome,2018,6(1):4. |
[13] | SHIN D,CHANG S Y,BOGERE P,et al.Beneficial roles of probiotics on the modulation of gut microbiota and immune response in pigs[J].PLoS One,2019,14(8):e0220843. |
[14] | 吕 存,孙玉亭,胡传炯,等.合生元对保育猪生长性能、粪样菌群结构和短链脂肪酸含量的影响[J].南京农业大学学报,2019,42(4):721-728.LV C,SUN Y T,HU C J,et al.Effects of synbiotics on the growth performance,microbial community and concentrations of short chain fatty acids in feces of nursery pigs[J].Journal of Nanjing Agricultural University,2019,42(4):721-728.(in Chinese) |
[15] | 刘 虹,王 琪,刘作华,等.猪肠道微生物区系的形成及营养调控[J].动物营养学报,2018,30(7):2480-2487.LIU H,WANG Q,LIU Z H,et al.Formation of intestinal microflora in pigs and nutrients regulation[J].Chinese Journal of Animal Nutrition,2018,30(7):2480-2487.(in Chinese) |
[16] | WANG X F,TSAI T,DENG F L,et al.Longitudinal investigation of the swine gut microbiome from birth to market reveals stage and growth performance associated bacteria[J].Microbiome,2019,7(1):109. |
[17] | KIM H B,ISAACSON R E.The pig gut microbial diversity:understanding the pig gut microbial ecology through the next generation high throughput sequencing[J].Vet Microbiol,2015,177(3-4):242-251. |
[18] | BARREA L,MUSCOGIURI G,ANNUNZIATA G,et al.From gut microbiota dysfunction to obesity:could short-chain fatty acids stop this dangerous course?[J].Hormones,2019,18(3):245-250. |
[19] | 刘鹏林,逄承健,邸爱婷,等.短链脂肪酸影响肠道动力的机制研究进展[J].结直肠肛门外科,2021,27(2):179-182.LIU P L,PANG C J,DI A T,et al.Research progress on the mechanism of short-chain fatty acids affecting intestinal motility[J].Journal of Colorectal & Anal Surgery,2021,27(2):179-182.(in Chinese) |
[20] | VENEGAS D P,DE LA FUENTE M K,LANDSKRON G,et al.Corrigendum:short chain fatty acids (SCFAs)-mediated gut epithelial and immune regulation and its relevance for inflammatory bowel diseases[J].Front Immunol,2019,10:277. |
[21] | 王子花,申瑞玲,李文全.短链脂肪酸的产生及作用[J].畜牧兽医科技信息,2007(2):12-13.WANG Z H,SHEN R L,LI W Q.Production and function of short chain fatty acids[J].Chinese Journal of Animal Husbandry and Veterinary Medicine,2007(2):12-13.(in Chinese) |
[22] | 朱伟云,余凯凡,慕春龙,等.猪的肠道微生物与宿主营养代谢[J].动物营养学报,2014,26(10):3046-3051.ZHU W Y,YU K F,MU C L,et al.Gut microbiota and host nutrition metabolism in pigs[J].Chinese Journal of Animal Nutrition,2014,26(10):3046-3051.(in Chinese) |
[23] | DIAO H,JIAO A R,YU B,et al.Gastric infusion of short-chain fatty acids can improve intestinal barrier function in weaned piglets[J].Genes Nutr,2019,14(1):4. |
[24] | ZHUANG M,SHANG W T,MA Q C,et al.Abundance of probiotics and butyrate-production microbiome manages constipation via short-chain fatty acids production and hormones secretion[J].Molecular Nutrition & Food Research,2019,63(23):1801187. |
[25] | CHEN X,XU J M,SU Y,et al.Effects of intravenous infusion with sodium butyrate on colonic microbiota,intestinal development- and mucosal immune-related gene expression in normal growing pigs[J].Front Microbiol,2018,9:1652. |
[26] | KNUDSEN K E B,LERKE H N,HEDEMANN M S,et al.Impact of diet-modulated butyrate production on intestinal barrier function and inflammation[J].Nutrients,2018,10(10):1499. |
[27] | MARKOWIAK-KOPEĆ P, Ś LIZ EWSKA K.The effect of probiotics on the production of short-chain fatty acids by human intestinal microbiome[J].Nutrients,2020,12(4):1107 |
[28] | CHEN T T,CHEN D W,TIAN G,et al.Soluble fiber and insoluble fiber regulate colonic microbiota and barrier function in a piglet model[J].Biomed Res Int,2019,2019:7809171. |
[29] | ZHANG L L,MU C L,HE X Y,et al.Effects of dietary fibre source on microbiota composition in the large intestine of suckling piglets[J].FEMS Microbiol Lett,2016,363(14):fnw138. |
[30] | 冯文林,伍海涛.基于短链脂肪酸调控5-HT探讨中医药治疗肠易激综合征作用机制[J].吉林中医药,2019,39(1):7-9,23.FENG W L,WU H T.Mechanism of the treatment of irritable bowel syndrome by traditional Chinese medicine based on the short chain fatty acid regulating 5-HT[J].Jilin Journal of Traditional Chinese Medicine,2019,39(1):7-9,23.(in Chinese) |
[31] | 孔祎頔,李 民,王桂芹.动物胆汁酸代谢与肠道微生态的互作关系[J].中国畜牧杂志,2020,56(8):38-44.KONG Y D,LI M,WANG G Q.Interaction between bile acid metabolism and intestinal micro-ecology in animals[J].Chinese Journal of Animal Science,2020,56(8):38-44.(in Chinese) |
[32] | KRIAA A,BOURGIN M,POTIRON A,et al.Microbial impact on cholesterol and bile acid metabolism:current status and future prospects[J].J Lipid Res,2019,60(2):323-332. |
[33] | 钟奇祺,张海波,幸清凤,等.肠道微生物及代谢产物对动物肠道免疫的研究进展[J].中国畜牧杂志,2021,57(2):28-33.ZHONG Q Q,ZHANG H B,XING Q F,et al.Advances in the effects of intestinal microorganisms and metabolites on host intestinal mucosal innate immune system[J].Chinese Journal of Animal Science,2021,57(2):28-33.(in Chinese) |
[34] | LONG S L,GAHAN C G M,JOYCE S A.Interactions between gut bacteria and bile in health and disease[J].Mol Aspects Med,2017,56:54-65. |
[35] | JAIN U,LAI C W,XIONG S S,et al.Temporal regulation of the bacterial metabolite deoxycholate during colonic repair is critical for crypt regeneration[J].Cell Host Microbe,2018,24(3):353-363.e5. |
[36] | GADALETA R M,ERPECUM K J V,OLDENBURG B,et al.Farnesoid X receptor activation inhibits inflammation and preserves the intestinal barrier in inflammatory bowel disease[J].Gut,2011,60(4):463-472. |
[37] | SONG M,YANG Q,ZHANG F L,et al.Hyodeoxycholic acid (HDCA) suppresses intestinal epithelial cell proliferation through FXR-PI3K/AKT pathway,accompanied by alteration of bile acids metabolism profiles induced by gut bacteria[J].FASEB J,2020,34(5):7103-7117. |
[38] | BURRIN D G,STOLL B,GUAN X F,et al.Glucagon-like peptide 2 dose-dependently activates intestinal cell survival and proliferation in neonatal piglets[J].Endocrinology,2005,146(1):22-32. |
[39] | LIN S,STOLL B,ROBINSON J,et al.Differential action of TGR5 agonists on GLP-2 secretion and promotion of intestinal adaptation in a piglet short bowel model[J].Am J Physiol Gastrointest Liver Physiol,2019,316(5):G641-G652. |
[40] | BURRIN D,STOLL B,MOORE D.Digestive physiology of the pig symposium:intestinal bile acid sensing is linked to key endocrine and metabolic signaling pathways[J].J Anim Sci,2013,91(5):1991-2000. |
[41] | LEE H,KO G.Antiviral effect of vitamin A on norovirus infection via modulation of the gut microbiome[J].Sci Rep,2016,6(1):25835. |
[42] | BAR-EL DADON S,REIFEN R.Vitamin A and the epigenome[J].Crit Rev Food Sci Nutr,2017,57(11):2404-2411. |
[43] | LI Y C,CHEN Y Z,DU J.Critical roles of intestinal epithelial vitamin D receptor signaling in controlling gut mucosal inflammation[J].J Steroid Biochem Mol Biol,2015,148:179-183. |
[44] | KONG J,ZHANG Z Y,MUSCH M W,et al.Novel role of the vitamin D receptor in maintaining the integrity of the intestinal mucosal barrier[J].Am J Physiol Gastrointest Liver Physiol,2008,294(1):G208-G216. |
[45] | BATTISTINI C,BALLAN R,HERKENHOFF M E,et al.Vitamin D modulates intestinal microbiota in inflammatory bowel diseases[J].Int J Mol Sci,2020,22(1):362. |
[46] | MCCOLE D F.Regulation of epithelial barrier function by the inflammatory bowel disease candidate gene,PTPN2[J].Ann N Y Acad Sci,2012,1257(1):108-114. |
[47] | LIN J J,SUN-WATERHOUSE D,CUI C.The therapeutic potential of diet on immune-related diseases:based on the regulation on tryptophan metabolism[J].Crit Rev Food Sci Nutr,2021:1-19,doi:10.1080/10408398.2021.1934813. |
[48] | LIANG H W,DAI Z L,KOU J,et al.Dietary L-tryptophan supplementation enhances the intestinal mucosal barrier function in weaned piglets:implication of tryptophan-metabolizing microbiota[J].Int J Mol Sci,2018,20(1):20. |
[49] | HU R Z,HE Z Y,LIU M,et al.Dietary protocatechuic acid ameliorates inflammation and up-regulates intestinal tight junction proteins by modulating gut microbiota in LPS-challenged piglets[J].J Anim Sci Biotechnol,2020,11(1):92. |
[50] | WEI H K,XUE H X,ZHOU Z X,et al.A carvacrol-thymol blend decreased intestinal oxidative stress and influenced selected microbes without changing the messenger RNA levels of tight junction proteins in jejunal mucosa of weaning piglets[J].Animal,2017,11(2):193-201. |
[51] | 黄妍君.维生素E及其衍生物对肠道屏障结构蛋白的保护作用研究[D].长沙:湖南师范大学,2018.HUANG Y J.The protective effects of vitamin E and its[D].Changsha:Hunan Normal University,2018.(in Chinese) |
[52] | ZHANG Y N,CHEN H Z,ZHU W Y,et al.Cecal infusion of sodium propionate promotes intestinal development and jejunal barrier function in growing pigs[J].Animals,2019,9(6):284. |
[53] | YAN H,AJUWON K M.Butyrate modifies intestinal barrier function in IPEC-J2 cells through a selective upregulation of tight junction proteins and activation of the Akt signaling pathway[J].PLoS One,2017,12(6):e0179586. |
[54] | WANG W K,CHEN D W,YU B,et al.Effects of dietary inulin supplementation on growth performance,intestinal barrier integrity and microbial populations in weaned pigs[J].Br J Nutr,2020,124(3):296-305. |
[55] | LIU J,ZHU H T,LI B,et al.Beneficial effects of butyrate in intestinal injury[J].J Pediatr Surgery,2020,55(6):1088-1093. |
[56] | LUTGENDORFF F,AKKERMANS L M A,SODERHOLM J D.The role of microbiota and probiotics in stress-induced gastrointestinal damage[J].Curr Mol Med,2008,8(4):282-298. |
[57] | CARIO E,GERKEN G,PODOLSKY D K.Toll-like receptor 2 controls mucosal inflammation by regulating epithelial barrier function[J].Gastroenterology, 2007,132(4):1359-1374. |
[58] | CARIO E,GERKEN G,PODOLSKY D K.Toll-like receptor 2 enhances ZO-1-associated intestinal epithelial barrier integrity via protein kinase C[J].Gastroenterology,2004,127(1):224-238. |
[59] | KARCZEWSKI J,TROOST F J,KONINGS I,et al.Regulation of human epithelial tight junction proteins by Lactobacillus plantarum in vivo and protective effects on the epithelial barrier[J].Am J Physiol Gastrointest Liver Physiol,2010,298(6):G851-G859. |
[60] | 杨文娟,来利华,王青青.肠道杯状细胞在肠道免疫调控中作用的研究进展[J].细胞与分子免疫学杂志,2018,34(11):1046-1050.YANG W J,LAI L H,WANG Q Q.Progress in the role of intestinal goblet cells in intestinal immune regulation[J].Chinese Journal of Cellular and Molecular Immunology,2018,34(11):1046-1050.(in Chinese) |
[61] | KARLSSON J,PVTSEP K,CHU H,et al.Regional variations in Paneth cell antimicrobial peptide expression along the mouse intestinal tract[J].BMC Immunol,2008,9:37 |
[62] | LEHOTZKY R E,PARTCH C L,MUKHERJEE S,et al.Molecular basis for peptidoglycan recognition by a bactericidal lectin[J].Proc Natl Acad Sci U S A,2010,107(17):7722-7727. |
[63] | KAYAMA H,OKUMURA R,TAKEDA K.Interaction between the microbiota,epithelia,and immune cells in the intestine[J].Ann Rev Immunol,2020,38:23-48. |
[64] | GAUDIER E,JARRY A,BLOTTIÈRE H M,et al.Butyrate specifically modulates MUC gene expression in intestinal epithelial goblet cells deprived of glucose[J].Am J Physiol Gastrointest Liver Physiol,2004,287(6):G1168-G1174. |
[65] | HANSSON G C,JOHANSSON M E V.The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria[J].Gut Microbes,2010,1(1):51-54. |
[66] | LIU Y,YU X J,ZHAO J X,et al.The role of MUC2 mucin in intestinal homeostasis and the impact of dietary components on MUC2 expression[J].Int J Biol Macromol,2020,164:884-891. |
[67] | MA S,YEOM J,LIM Y H.Dairy Propionibacterium freudenreichii ameliorates acute colitis by stimulating MUC2 expression in intestinal goblet cell in a DSS-induced colitis rat model[J].Sci Rep,2020,10(1):5523. |
[68] | LÓPEZ-BOADO Y S,WILSON C L,HOOPER L V,et al.Bacterial exposure induces and activates matrilysin in mucosal epithelial cells[J].J Cell Biol,2000,148(6):1305-1315. |
[69] | XIA X,ZHOU J,LIU H N,et al.Dietary lysozyme supplementation contributes to enhanced intestinal functions and gut microflora of piglets[J].Food Funct,2019,10(3):1696-1706. |
[70] | 王海昆,崔 旻,姚 萍.肠道菌群变化对肠上皮细胞Myd88蛋白及炎症因子的影响[J].中国微生态学杂志,2018,30(9):1004-1007,1012.WANG H K,CUI M,YAO P.Impact of intestinal flora variation on Myd88 protein and inflammatory factors in intestinal epithelial cells of rats[J].Chinese Journal of Microecology,2018,30(9):1004-1007,1012.(in Chinese) |
[71] | HE B,XU W F,SANTINI P A,et al.Intestinal bacteria trigger T cell-independent immunoglobulin A2 class switching by inducing epithelial-cell secretion of the cytokine APRIL[J].Immunity,2007,26(6):812-826. |
[72] | JANDHYALA S M,TALUKDAR R,SUBRAMANYAM C,et al.Role of the normal gut microbiota[J].World J Gastroenterol,2015,21(29):8787-8803. |
[73] | YANAGIBASHI T,HOSONO A,OYAMA A,et al.IgA production in the large intestine is modulated by a different mechanism than in the small intestine:Bacteroides acidifaciens promotes IgA production in the large intestine by inducing germinal center formation and increasing the number of IgA+ B cells[J].Immunobiology,2013,218(4):645-651. |
[74] | 胡红莲,高 民.肠道屏障功能及其评价指标的研究进展[J].中国畜牧杂志,2012,48(17):78-82.HU H L,GAO M.Research advance in intestinal barrier function and evaluation index[J].Chinese Journal of Animal Science,2012,48(17):78-82.(in Chinese) |
[75] | LI Y H,HOU S L,PENG W,et al.Oral administration of Lactobacillus delbrueckii during the suckling phase improves antioxidant activities and immune responses after the weaning event in a piglet model[J].Oxid Med Cell Longev,2019,2019:6919803. |
[76] | 邢帅兵,陈代文,余 冰,等.枯草芽孢杆菌对断奶仔猪生长性能和肠道形态、黏膜免疫及菌群数量的影响[J].动物营养学报,2020,32(5):2066-2073.XING S B,CHEN D W,YU B,et al.Effects of Bacillus subtilis on growth performance,intestinal morphology,mucosal immune and microflora number of weaned piglets[J].Chinese Journal of Animal Nutrition,2020,32(5):2066-2073.(in Chinese) |
[77] | LU J F,ZHANG X Y,LIU Y H,et al.Effect of fermented corn-soybean meal on serum immunity,the expression of genes related to gut immunity,gut microbiota,and bacterial metabolites in grower-finisher pigs[J].Front Microbiol,2019,10:2620. |
[1] | ZHANG Jixian, FAN Dingkun, FU Yuze, JIAO Shuai, MA Tao, BI Yanliang, ZHANG Naifeng. Research Progress on Mechanism and Application of Postbiotics in Regulating Animal Intestinal Health [J]. Acta Veterinaria et Zootechnica Sinica, 2024, 55(5): 1926-1935. |
[2] | KANG Jiawei, HUANG Xuankai, WANG Zhipeng, ZHANG Aizhen, MENG Fangrong, GAI Peng, BAO Junfu, SUN Kexin, SONG Shaokang, SUN Pan, CHEN Yichuan, ZHANG Lei, GAO Shengyue, CHANG Minghang. Estimation of Genetic Parameters for Growth, Reproduction, and Body Measurements Traits in Large White Pigs [J]. Acta Veterinaria et Zootechnica Sinica, 2024, 55(5): 1936-1944. |
[3] | SUN Wenli, WANG Haoqi, ZE Licuo, GAO Yufan, ZHANG Feifan, ZHANG Jian, DUAN Mengqi, SHANG Peng, QIANG Bayangzong. Polymorphism of Pro-Inflammatory Factors (IL-1β, IL-6, TNF-α) in Tibetan Pigs and Its Association Analysis with Immune Traits [J]. Acta Veterinaria et Zootechnica Sinica, 2024, 55(5): 1958-1969. |
[4] | XIAO Le, LIU Junyuan, ZENG Wenyu, WANG Qin, HAN Wenjue, LIU Yanling, FAN Yu, XU Yuting, YANG Beini, XIAO Xiong, WANG Zili. Microbiome and Transcriptome Analyses Revealed the Regulatory Mechanism of Xiangsha Liujunzi Decoction on Ileal Injury Induced by ETEC in Weaned Piglets with Diarrhea [J]. Acta Veterinaria et Zootechnica Sinica, 2024, 55(2): 797-808. |
[5] | NIU Naiqi, ZHAO Runze, ZONG Wencheng, LIU Xiance, LIU Hai, SHI Guohua, JING Xitao, ZHANG Longchao. Association of Polymorphisms of GREB1L and MIB1 Genes with Rib Number and Carcass Traits in Beijing Black Pigs [J]. Acta Veterinaria et Zootechnica Sinica, 2024, 55(1): 79-86. |
[6] | ZHU Xueli, ZHANG Longchao, WANG Lixian, PU Lei, LIU Xin. Association Analysis of AQP9 and RPS10 Gene Polymorphisms with Backfat Thickness in Beijing Black Pigs [J]. Acta Veterinaria et Zootechnica Sinica, 2024, 55(1): 87-98. |
[7] | SHI Shengjie, WANG Liguang, GAO Lei, CAI Chuanjiang, HE Weixian, CHU Guiyan. Effect of miR-24-3p on Estradiol Synthesis in Porcine Granulosa Cells [J]. Acta Veterinaria et Zootechnica Sinica, 2024, 55(1): 169-178. |
[8] | WANG Ruiling, WANG Xueyan, WANG Feifei, KONG Weiyi, MAO Yongxia, LIU Xin, DING Hui, XU Lihua, GUO Yansheng. Study on the Changes of Blood Oxidized Lipid Group in Postpartum Dairy Cows with Acute Endometritis [J]. Acta Veterinaria et Zootechnica Sinica, 2024, 55(1): 373-387. |
[9] | CHEN Ying, ZHONG Ruqing, CHEN Liang, ZHANG Hongfu. Utilization of Dietary Fiber and Its Impact on Nutrient Digestion of Pigs [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(9): 3745-3757. |
[10] | ZHANG Zhaobo, HOU Liming, LI Pinghua, DU Taoran, WANG Zhongyu, WU Chengwu, HUANG Ruihua. Screening Candidate Metabolites of Dietary Fiber Affecting Meat Quality Traits of Erhualian Pigs Based on Plasma Metabolomics [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(9): 3758-3769. |
[11] | HUANG Jiang, LI Chuang, CUI Yueqi, YUAN Xueying, ZHAO Zhicheng, LIU Yu, ZHOU Yulong, ZHU Zhanbo, ZHANG Zecai. Study on the Effect of Gut Microbiota Disturbance on Susceptibility to BVDV Based on a Mouse Model [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(8): 3466-3473. |
[12] | JIAO Guangming, LÜ Yingguang, SANG Jinfang, KOU Zhipeng, LIU Tao, WANG Yue, LU Xiangyu, PIAO Chenxi, MA Yajun, ZHANG Jiantao, WANG Hongbin. Effect of Adipose Mesenchymal Stem Cells in Combination with Methylprednisolone on Allogeneic Skin Grafts in Minipigs [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(8): 3533-3545. |
[13] | LIAN Yuju, ZHANG Zhiyuan, LIAO Xiaobo, WEI Hongjiang, YIN Yulong, LIU Mei. Breeding Methods and Application Progress of Medical Miniature Pigs [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(7): 2667-2682. |
[14] | ZHOU Fuchen, YE Jian, GUO Caijin, ZENG Haiyu, WU Zhenfang, DONG Linsong, CAI Gengyuan. Litter Effect Analysis and Genetic Parameters Estimation of Lean Meat Percentage Trait in Duroc Pigs [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(6): 2288-2296. |
[15] | ZHU Qian, CHENG Yating, LI Ruixuan, LI Chenjian, LIU Yating, KONG Xiangfeng. Effects of Probiotics and Synbiotics Addition to Sows’ Diet on Fatty Acid Composition and Related Gene Expression in Muscle of Offspring Bama Mini-Pigs [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(6): 2458-2467. |
Viewed | ||||||
Full text |
|
|||||
Abstract |
|
|||||