丁酸介导下肠道菌群与宿主免疫互作机制的研究进展

doi:10.11843/j.issn.0366-6964.2021.010.003

Abstract

Abstract: The intestinal microbes and their metabolites play an important role in the growth and functional improvement of the animal. When the dynamic balance between the host and the intestinal microbes is broken, the local or systemic inflammation is induced. Butyrate not only provides energy for the body as an energy substance, but also regulates the host's innate immunity and adaptive immune state, promotes the body's immune response. Butyrate affects the host's secretion of antimicrobial peptides(AMPs) to prevent translocation of intestinal pathogenic bacteria and maintain steady state of intestinal microbes. This article will systematically introduce the research progress of the interaction mechanism between the intestinal microbes and the host immune system mediated by butyrate, and clarify their important role in the steady state of intestinal health.

Key words: intestinal microbes, butyrate, host immunity, crosstalk mechanism

CLC Number:

S852.4

LIANG Kaiyang, SUN Zhihong, TAN Zhiliang, LIU Yong. Crosstalk Mechanism between Intestinal Microbes and Host Immunity Mediated by Microbial Metabolites-Butyrate[J]. Acta Veterinaria et Zootechnica Sinica, 2021, 52(10): 2710-2720.

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Crosstalk Mechanism between Intestinal Microbes and Host Immunity Mediated by Microbial Metabolites-Butyrate

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