miR-502在犬乳腺癌中的表达及意义

doi:10.11843/j.issn.0366-6964.2020.01.022

Abstract

Abstract: The aim of this study was to investigate the expression level of miR-502 and its clinical significance in canine breast cancer tissues. A total of 30 cases of canine breast cancer tissues and normal adjacent tissues were enrolled in this study. The expression levels of miR-502 were detected by real-time quantitative polymerase chain reaction (qRT-PCR). The relationship between the levels of miR-502 and the clinicopathological features (age, tumor size, histological grade and metastasis state) of canine breast cancer were analyzed. The experiment results showed that compared with the adjacent normal tissues, the levels of miR-502 transcription in canine breast cancer tissues increased significantly (P<0.01). The transcription of miR-502 was related with histological grade and metastasis in canine breast cancer (P<0.05); but not related with tumor size or age (P>0.05). The miR-502 transcription level is up-regulated in canine breast cancer that related with tumorigenesis and progression of canine breast cancer. miR-502 can be used as a tumor marker for diagnosis prediction of canine breast cancer.

Key words: breast cancer, canine, miR-502, gene expression

CLC Number:

S857.4

REN Xiaoli, FAN Yuying, SHI Dongmei, TIAN Chuanwen, LU Shuilong, LIU Yun. Expressions of miR-502 in Canine Breast Cancer and Clinical Significance[J]. Acta Veterinaria et Zootechnica Sinica, 2020, 51(1): 193-197.

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Expressions of miR-502 in Canine Breast Cancer and Clinical Significance

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