靶向MAPK信号通路调控脂肪细胞分化的microRNAs

doi:10.11843/j.issn.0366-6964.2016.11.002

Abstract

Abstract:

Adipocyte differentiation is a complicated process in which pluripotent mesenchymal stem cells (MSCs) differentiate into mature adipocytes. The process of adipocyte differentiation is strictly regulated by a number of transcription factors, hormones and signaling pathway molecules. In vivo and in vitro research has revealed that microRNAs (miRNAs) are also involved in adipocyte differentiation and play a role by targeting transcription factors and key signaling molecules. MAPK signaling pathway is one of important signaling systems which transduce the extracellular signal to intracellular space and cause cell response. The studies showed that, miRNAs can target certain genes in MAPK and affect its signal transduction, thus regulating adipocyte differentiation. Therefore, a summary of researches how miRNAs change the signal transduction of MAPK pathway and regulate adipocyte differentiation was performed in order to further understand the adipocyte differentiation mechanism and offer new ideas for curing the fat-associated diseases.

CLC Number:

S813.2

ZHANG Xiu-xiu, GUO Yun-tao, HUANG Wan-long, LI Yuan, MIAO Xiang-yang. Regulation of Adipocyte Differentiation via microRNAs Targeting MAPK Signaling Pathway[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2016, 47(11): 2159-2166.

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Regulation of Adipocyte Differentiation via microRNAs Targeting MAPK Signaling Pathway

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