动物皮肤伤口愈合的分子机制与创新治疗策略

doi:10.11843/j.issn.0366-6964.2025.09.012

摘要/Abstract

摘要： 皮肤伤口愈合是一个涉及炎症、组织再生和细胞外基质重塑的复杂生理过程，其失调可能导致疤痕增生或慢性溃疡，影响皮肤功能。本文综述了动物皮肤伤口愈合的分子机制，探讨了包括新型药物开发、改善药物传输、调控激素及外源信号、基因治疗和组织工程法在内的多种修复策略。这些方法通过改善药物传输、调控炎症反应、促进血管及组织再生，从而有效提升了伤口愈合效果。本研究旨在为未来动物皮肤伤口愈合提供新的视角，指出了潜在的研究思路和方向，以期开发出更高效、安全的治疗策略，改善动物的健康和福利。

关键词: 动物福利, 皮肤创伤, 伤口愈合, 分子机制, 治疗方法

Abstract: Skin wound healing is a complex physiological process involving inflammation, tissue regeneration, and extracellular matrix remodeling. Dysregulation of this process can lead to excessive scarring or chronic ulcers, impairing skin function. This review summarizes the molecular mechanisms underlying wound healing in animal skin and explores various repair strategies, including novel drug development, enhanced drug delivery, regulation of hormones and external signals, gene therapy, and tissue engineering approaches. These methods improve wound healing outcomes by optimizing drug delivery, modulating inflammatory responses, and promoting vascularization and tissue regeneration. This study aims to provide new insights into animal skin wound healing, highlight potential research directions, and contribute to the development of safer and more effective therapeutic strategies to enhance animal health and welfare.

Key words: animal welfare, skin trauma, wound healing, molecular mechanisms, therapeutic approaches

中图分类号:

S857.5

余时隆, 岳潇雨, 栾悦, 王勤. 动物皮肤伤口愈合的分子机制与创新治疗策略[J]. 畜牧兽医学报, 2025, 56(9): 4267-4278.

YU Shilong, YUE Xiaoyu, LUAN Yue, WANG Qin. Molecular Mechanisms and Innovative Therapeutic Strategies for Cutaneous Wound Healing in Animals[J]. Acta Veterinaria et Zootechnica Sinica, 2025, 56(9): 4267-4278.

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