m6A修饰调控circRNA的研究进展

doi:10.11843/j.issn.0366-6964.2023.10.002

摘要/Abstract

摘要： Circular RNAs （circRNAs）是由pre-RNA通过反向剪接使5'尾端和3'polyA端以共价结合的形式形成的环状RNA，在多种生物学过程起重要作用。N6-甲基腺苷修饰（N6-methyladenosine，m⁶A）是真核生物中最丰富的修饰之一，参与调控RNA的剪接、翻译及降解等过程。现越来越多证据表明m⁶A修饰也存在于环状RNA中并且介导环状RNA的翻译、降解等。本文主要综述了circRNA在真核生物中的合成和作用机制以及m⁶A修饰对circRNA的调控作用。

关键词: circRNAs, 作用机制, m⁶A修饰

Abstract: Circular RNAs (circRNAs) are single-stranded, covalently closed RNA that were generated by 3' polyA and 5'tail of pre-mRNA via back-splicing. CircRNAs play a crucial role in varieties biological processes. N6-methyladenosine (m⁶A) is one of the most abundant modifications in eukaryotes, which regulate splicing, translation and degradation of RNA. There is increasing evidence that m⁶A modification also controlling circRNAs metabolism, including translation, degradation and so on. In this review, the biogenesis and function of circRNAs were summerized. Moreover, the role of m⁶A modification in the regulation of circRNAs was discussed.

Key words: circRNAs, function, m⁶A modification

中图分类号:

S811.3

杨志梅, 梁成成, 张殿琦, 李雪峰, 昝林森. m⁶A修饰调控circRNA的研究进展[J]. 畜牧兽医学报, 2023, 54(10): 4016-4027.

YANG Zhimei, LIANG Chengcheng, ZHANG Dianqi, LI Xuefeng, ZAN Linsen. Research Progress on the Regulation of circRNA by m⁶A Modification[J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(10): 4016-4027.

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m⁶A修饰调控circRNA的研究进展

Research Progress on the Regulation of circRNA by m⁶A Modification

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