ALV-E的结构、活性调控以及对宿主功能的影响

doi:10.11843/j.issn.0366-6964.2023.07.002

摘要/Abstract

摘要： 禽白血病病毒E亚群（ALV-E）是整合在鸡基因组中的内源性逆转录病毒元件。近年来，随基因组测序的深入，许多新的ALV-E被发现，但关于ALV-E对宿主的影响尚不清楚。本文对ALV-E的结构及其功能进行总结，阐述了ALV-E转录启动活性的调控以及ALV-E整合位置的结构特征，最后讨论了ALV-E对宿主功能的影响，为深入探究禽内源性白血病病毒的宿主功能及其表达调控机制提供参考。

关键词: 内源性逆转录病毒, 生物合成, 转录调控, 生物学功能

Abstract: Avian leukemia virus E subgroup (ALV-E) is an endogenous retroviral element integrated in chicken genome. In recent years, many new ALVEs have been described with the develop-ment of genome sequencing projects. However, the ALV-E effects on host have not been fully understood. In this review, the structure and function of ALV-E were summarized, and the regu-lation of transcription initiation activity of ALV-E was elaborated, and the structure characteristics of ALV-E location in host genome was expounded. Finally, the effects of ALV-E on host function was discussed, which would provide reference for further understanding the function and expression regulation mechanism of avian leukemia virus in the genome of host.

Key words: endogenous retrovirus, biosynthesis, transcriptional regulation, biological function

中图分类号:

S813.1

郭艳丽, 李可强, 白少川, 王涛, 王德贺, 王麒, 李兰会. ALV-E的结构、活性调控以及对宿主功能的影响[J]. 畜牧兽医学报, 2023, 54(7): 2683-2691.

GUO Yanli, LI Keqiang, BAI Shaochuan, WANG Tao, WANG Dehe, WANG Qi, LI Lanhui. The Structure, Activity Regulation of ALV-E and Its Effects on Host Function[J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(7): 2683-2691.

参考文献 62

[1]	LIU C N, ZHENG S M, WANG Y Q, et al.Detection and molecular characterization of recombinant avian leukosis viruses in commercial egg-type chickens in China[J].Avian Pathol, 2011, 40(3):269-275.
[2]	MAYS J K, BLACK-PYRKOSZ A, MANSOUR T, et al.Endogenous avian leukosis virus in combination with Serotype 2 Marek's disease virus significantly boosted the incidence of lymphoid leukosis-like bursal lymphomas in susceptible chickens[J].J Virol, 2019, 93(23):e00861-19.
[3]	HUDA A, POLAVARAPU N, JORDAN I K, et al.Endogenous retroviruses of the chicken genome[J].Biol Direct, 2008, 3(1):9.
[4]	DAI Y D, DIAS P, MARGOSIAK A, et al.Endogenous retrovirus Gag antigen and its gene variants are unique autoantigens expressed in the pancreatic islets of non-obese diabetic mice[J].Immunol Lett, 2020, 223:62-70.
[5]	王麒, 王晗, 张秀玲, 等.鸡内源白血病病毒ev21与慢羽非连锁分析和LTR区启动子活性分析[J].畜牧兽医学报, 2017, 48(5):930-937.WANG Q, WANG H, ZHANG X L, et al.Analysis of non-linkage between endogenous ALV-ev21 and Late feathering of chickens and its promoter activity of LTR[J].Acta Veterinaria et Zootechnica Sinica, 2017, 48(5):930-937.(in Chinese)
[6]	CULLEN B R, LOMEDICO P T, JU G.Transcriptional interference in avian retroviruses-implications for the promoter insertion model of leukaemogenesis[J].Nature, 1984, 307(5948):241-245.
[7]	HUGHES S H.Sequence of the long terminal repeat and adjacent segments of the endogenous avian virus Rous-associated virus 0[J].J Virol, 1982, 43(1):191-200.
[8]	PETTERSSON M E, JERN P.Whole-genome analysis of domestic chicken selection lines suggests segregating variation in ERV makeups[J].Genes (Basel), 2019, 10(2):162.
[9]	HU X M, ZHU W Q, CHEN S H, et al.Expression patterns of endogenous avian retrovirus ALVE1 and its response to infection with exogenous avian tumour viruses[J].Arch Virol, 2017, 162(1):89-101.
[10]	CHANG C M, COVILLE J L, COQUERELLE G, et al.Complete association between a retroviral insertion in the tyrosinase gene and the recessive white mutation in chickens[J].BMC Genom, 2006, 7:19.
[11]	GAVORA J S, KUHNLEIN U, CRITTENDEN L B, et al.Endogenous viral genes:association with reduced egg production rate and egg size in White Leghorns[J].Poult Sci, 1991, 70(3):618-623.
[12]	WEISS R A.On the concept and elucidation of endogenous retroviruses[J].Philos Trans R Soc Lond B Biol Sci, 2013, 368(1626):20120494.
[13]	CRITTENDEN L B, SALTER D W.Spontaneous mobility of subgroup a avian leukosis virus pro viruses in the genome of the chicken[J].Avian Pathol, 1998, 27(S1):S26-S35.
[14]	李拓凡.我国十种优质鸡群内源性禽白血病病毒分子特征及其与J亚群禽白血病病毒流行株相关性的研究[D].武汉:长江大学, 2016.LI T F.Research on the molecular characteristics of endogenous avian leukosis viruses in ten types of Chinese high quality flocks and their roles in the prevalent subgroup J avian leukosis viruses strains in China[D].Wuhan:Yangtze University, 2016.(in Chinese)
[15]	白少川, 张乐超, 葛琳涵, 等.内源性逆转录病毒的转录表达与宿主功能关系的研究进展[J].畜牧兽医学报, 2021, 52(8):2107-2114.BAI S C, ZHANG L C, GE L H, et al.Research progress of relation between transcriptional expression of endogenous retrovirus and host function[J].Acta Veterinaria et Zootechnica Sinica, 2021, 52(8):2107-2114.(in Chinese)
[16]	GIFFORD R, TRISTEM M.The evolution, distribution and diversity of endogenous retroviruses[J].Virus Genes, 2003, 26(3):291-315.
[17]	MASON A S, LUND A R, HOCKING P M, et al.Identification and characterisation of endogenous Avian Leukosis Virus subgroup E (ALVE) insertions in chicken whole genome sequencing data[J].Mob DNA, 2020, 11(1):22.
[18]	MASON A S, FULTON J E, SMITH J.Endogenous avian leukosis virus subgroup E elements of the chicken reference genome[J].Poult Sci, 2020, 99(6):2911-2915.
[19]	MASON A S, MIEDZINSKA K, KEBEDE A, et al.Diversity of endogenous avian leukosis virus subgroup E (ALVE) insertions in indigenous chickens[J].Genet Sel Evol, 2020, 52(1):29.
[20]	BOLISETTY M, BLOMBERG J, BENACHENHOU F, et al.Unexpected diversity and expression of avian endogenous retroviruses[J]. mBio, 2012, 3(5):e00344-12.
[21]	SU Q, LI Y, LI W H, et al.Molecular characteristics of avian leukosis viruses isolated from indigenous chicken breeds in China[J].Poult Sci, 2018, 97(8):2917-2925.
[22]	葛琳涵, 白少川, 李雪梅, 等.鸡内源性白血病毒ev21与其侧翼区SNP位点的连锁关系[J].河北农业大学学报, 2020, 43(6):101-107.GE L H, BAI S C, LI X M, et al.The linkage between chicken endogenous leukemia virus ev21 and the SNP locus in the cell flanking region[J].Journal of Hebei Agricultural University, 2020, 43(6):101-107.(in Chinese)
[23]	LI Z Y, CHEN Y H, LI W R, et al.Cell division cycle 2 protects neonatal rats against hyperoxia-induced bronchopulmonary dysplasia[J].Yonsei Med J, 2020, 61(8):679-688.
[24]	盘道兴, 王振, 杨茂林, 等.不同品种猪PPARγ和C/EBPα基因表达规律与肌内脂肪含量的相关[J].中国农业科学, 2017, 50(1):171-182.PAN D X, WANG Z, YANG M L, et al.Association of the PPARγ and C/EBPα gene expression with intramuscular fat content in different varieties of pig[J].Scientia Agricultura Sinica, 2017, 50(1):171-182.(in Chinese)
[25]	DARAEI A, IZADI P, KHORASANI G, et al.Methylation of progesterone receptor isoform A promoter in normal breast tissue:an epigenetic link between early age at menarche and risk of breast cancer[J].J Cell Biochem, 2019, 120(8):12393-12401.
[26]	SUN X H, WANG Y, JI K H, et al.NRF2 preserves genomic integrity by facilitating ATR activation and G2 cell cycle arrest[J].Nucleic Acids Res, 2020, 48(16):9109-9123.
[27]	WESOLOWSKI R, KOWENZ-LEUTZ E, ZIMMERMANN K, et al.Myeloid transformation by MLL-ENL depends strictly on C/EBP[J].Life Sci Alliance, 2021, 4(1):e202000709.
[28]	WALLACE A D, WENDT G A, BARCELLOS L F, et al.To ERV is human:A phenotype-wide scan linking polymorphic human endogenous retrovirus-K insertions to complex phenotypes[J].Front Genet, 2018, 9:298.
[29]	RUDDELL A.Transcription regulatory elements of the avian retroviral long terminal repeat[J].Virology, 1995, 206(1):1-7.
[30]	WANG Z P, QU L J, YAO J F, et al.An EAV-HP insertion in 5' Flanking region of SLCO1B3 causes blue eggshell in the chicken[J].PLoS Genet, 2013, 9(1):e1003183.
[31]	WRAGG D, MWACHARO J M, ALCALDE J A, et al.Endogenous retrovirus EAV-HP linked to blue egg phenotype in Mapuche fowl[J].PLoS One, 2013, 8(8):e71393.
[32]	胡序明, 朱文奇, 陈世豪, 等.禽内源性反转录病毒ALVE1 LTR转录水平分析[J].中国动物传染病学报, 2015, 23(5):27-31.HU X M, ZHU W Q, CHEN S H, et al.Transcriptional analysis of avian endogenous retrovirus ALVE1 LTR[J].Chinese Journal of Animal Infectious Diseases, 2015, 23(5):27-31.(in Chinese)
[33]	THOMPSON P J, MACFARLAN T S, LORINCZ M C.Long terminal repeats:from parasitic elements to building blocks of the transcriptional regulatory repertoire[J].Mol Cell, 2016, 62(5):766-776.
[34]	MONTESION M, WILLIAMS Z H, SUBRAMANIAN R P, et al.Promoter expression of HERV-K (HML-2) provirus-derived sequences is related to LTR sequence variation and polymorphic transcription factor binding sites[J].Retrovirology, 2018, 15(1):57.
[35]	朱文奇, 胡序明, 陈世豪, 等.miR-155体外特异性靶向鸡内源性反转录病毒ALVE1 env转录物的研究[J].畜牧与兽医, 2016, 48(5):7-11.ZHU W Q, HU X M, CHEN S H, et al.Studies on avian endogenous retrovirus ALVE1 env transcripts specifically targeted by miR-155 in vitro[J].Animal Husbandry & Veterinary Medicine, 2016, 48(5):7-11.(in Chinese)
[36]	CHUNG H C, NGUYEN V G, MOON H J, et al.Regulation of porcine endogenous retrovirus by dual LTR1+2 (Long Terminal Region) miRNA in primary porcine kidney cells[J].J Vet Sci, 2019, 20(5):e50.
[37]	LEE H E, JO A, IM J, et al.Characterization of the Long Terminal Repeat of the endogenous retrovirus-derived microRNAs in the Olive Flounder[J].Sci Rep, 2019, 9(1):14007.
[38]	CONKLIN K F.Activation of an endogenous retrovirus enhancer by insertion into a heterologous context[J].J Virol, 1991, 65(5):2525-2532.
[39]	戴开宇.猪AQP3基因启动子区变异对其表达水平和PEDV抗性的调控作用分析[D].扬州:扬州大学, 2020.DAI K Y.Analysis of the effect of variation in porcine AQP3 gene promoter on its expression level and PEDV resistance[D].Yangzhou:Yangzhou University, 2020.(in Chinese)
[40]	王麒.太行鸡胚内源白血病病毒ev21表达调控研究[D].保定:河北农业大学, 2019.WANG Q.Regulation of endogenous leukemia virus ev21 expression in Taihang chicken embryos[D].Baoding:Agricultural University of Hebei, 2019.(in Chinese)
[41]	YU Y, ZHANG H M, TIAN F, et al.Quantitative evaluation of DNA methylation patterns for ALVE and TVB genes in a neoplastic disease susceptible and resistant chicken model[J].PLoS One, 2008, 3(3):e1731.
[42]	JOHNSON J A, HENEINE W.Characterization of endogenous avian leukosis viruses in chicken embryonic fibroblast substrates used in production of measles and mumps vaccines[J].J Virol, 2001, 75(8):3605-3612.
[43]	FULTON J E, MASON A S, WOLC A, et al.The impact of endogenous Avian Leukosis Viruses (ALVE) on production traits in elite layer lines[J].Poult Sci, 2021, 100(6):101121.
[44]	CHEN W G, QU H, LI C Y, et al.Polymorphism of avian leukosis virus subgroup E loci showing selective footprints in chicken[J].Biochem Genet, 2014, 52(11-12):524-537.
[45]	宁中华, 王忠, 彭丹芳, 等.禽白血病和羽速基因对白壳蛋鸡生产性能的影响[J].中国畜牧杂志, 2005, 41(10):23-25.NING Z H, WANG Z, PENG D F, et al.Effect of avian leukosis virus and sex-linked feather gene on performance of white Leghorn Hens[J].Chinese Journal of Animal Science, 2005, 41(10):23-25.(in Chinese)
[46]	ROBINSON H L, ASTRIN S M, SENIOR A M, et al.Host susceptibility to endogenous viruses:defective, glycoprotein-expressing proviruses interfere with infections[J].J Virol, 1981, 40(3):745-751.
[47]	KA S, KERJE S, BORNOLD L, et al.Proviral integrations and expression of endogenous avian leucosis virus during long term selection for high and low body weight in two chicken lines[J].Retrovirology, 2009, 6(1):68.
[48]	董征英.内源性ALV的全基因测序、J-ALV实时荧光定量PCR检测方法的建立及应用[D].泰安:山东农业大学, 2012.DONG Z Y.Development and application of real-time PCR for detection of avian leukosis virus subgroup J[D].Taian:Shandong Agricultural University, 2012.(in Chinese)
[49]	SMITH EUGENE J, FADLY A M, LEVIN I, et al.The Influence of ev 6 on the immune response to avian leukosis virus infection in rapid-feathering progeny of slow-and rapid-feathering dams[J].Poult Sci, 1991, 70(8):1673-1678.
[50]	MO G D, WEI P, HU B W, et al.Advances on genetic and genomic studies of ALV resistance[J].J Anim Sci Biotechnol, 2022, 13(1):123.
[51]	CHIAPPINELLI K B, STRISSEL P L, DESRICHARD A, et al.Inhibiting DNA methylation causes an interferon response in cancer via dsRNA including endogenous retroviruses[J].Cell, 2015, 162(5):974-986.
[52]	ITO J, WATANABE S, HIRATSUKA T, et al.Refrex-1, a soluble restriction factor against feline endogenous and exogenous retroviruses[J].J Virol, 2013, 87(22):12029-12040.
[53]	KOZAK C A.Origins of the endogenous and infectious laboratory mouse gammaretroviruses[J].Viruses, 2014, 7(1):1-26.
[54]	ASWAD A, KATZOURAKIS A.Paleovirology and virally derived immunity[J].Trends Ecol and Evol, 2012, 27(11):627-636.
[55]	NADEAU M J, MANGHERA M, DOUVILLE R N.Inside the envelope:Endogenous retrovirus-K env as a biomarker and therapeutic target[J].Front Microbiol, 2015, 6:1244.
[56]	王归燕.内源性逆转录病毒ev-1对鸡抗ALV-J先天免疫的影响[D].广州:华南农业大学, 2020.WANG G Y.Effects of endogenous retrovirus ev-1 on innate immunity of ALV-J infection chicken[D].Guangzhou:South China Agricultural University, 2020.(in Chinese)
[57]	LUO H, HU X M, WU H X, et al.Activation of lnc-ALVE1-AS1 inhibited ALV-J replication through triggering the TLR3 pathway in chicken macrophage like cell line[J].Vet Res Commun, 2023, 47(2):431-443.
[58]	MASON A S.Falling fowl of the chicken reference genome:pitfalls of studying polymorphic endogenous retroviruses[J]. Retrovirology, 2021, 18(1):10.
[59]	CHEN J F, HUA G Y, HAN D P, et al.An EAV-HP insertion in the promoter region of SLCO1B3 has pleiotropic effects on chicken liver metabolism based on the transcriptome and proteome analysis[J].Sci Rep, 2021, 11(1):7571.
[60]	CRITTENDEN L B, SMITH E J, FADLY A M.Influence of endogenous viral (ev) gene expression and strain of exogenous avian leukosis virus (ALV) on mortality and ALV infection and shedding in chickens[J].Avian Dis, 1984, 28(4):1037-1056.
[61]	FEDERSPIEL M J, CRITTENDEN L B, PROVENCHER L P, et al.Experimentally introduced defective endogenous proviruses are highly expressed in chickens[J].J Virol, 1991, 65(1):313-319.
[62]	SHI M Y, TAN L, ZHANG Y D, et al.Characterization and functional analysis of chicken APOBEC4[J].Dev Comp Immunol, 2020, 106:103631.