NF-κB信号通路调控奶牛乳腺炎的分子作用机制

doi:10.11843/j.issn.0366-6964.2021.010.005

摘要/Abstract

摘要： 乳腺炎通常是由微生物感染引起的乳腺炎症反应，是奶牛最常见的疾病之一，可导致牛奶产量及品质下降，奶牛利用年限减少，严重地影响着牧场的经济效益。近年来，学者们在奶牛乳腺炎分子调节机制方面开展了大量研究，发现NF-κB及其信号通路可参与调控多个免疫相关基因的表达，在细胞炎症反应和免疫应答等过程起关键性作用，也是奶牛乳腺炎研究的热点。本文阐述了奶牛乳腺炎的病因和病理变化，以及NF-κB信号通路与机体免疫的关系，并重点综述了mRNA、非编码RNA（miRNA、lncRNA和circRNA）及生物活性物质通过NF-κB信号通路调控奶牛乳腺炎的最新研究进展，为奶牛乳腺炎的分子调控网络解析、抗乳腺炎分子育种与生物活性药物研发提供参考。

关键词: 奶牛, 乳腺炎, NF-κB信号通路, 非编码RNA, 生物活性物质

Abstract: Mastitis is usually an inflammatory reaction of mammary gland caused by microbial infection, and is one of the most common diseases of dairy cows, which can lead to the decline of milk yield and quality, reduce the productive life of dairy cows, and seriously affect the economic benefits of pasture. In recent years, scholars have carried out a lot of researches on the molecular regulation mechanism of dairy cow mastitis, and found that NF-κB and its signaling pathway can participate in regulating the expression of many immune related genes, and play a key role in the process of cellular inflammatory response and immune response, which is also a hotspot in the research of dairy cow mastitis. This paper reviewed the etiology and pathological changes of dairy cow mastitis, as well as the relationship between NF-κB signaling pathway and body immunity, and the latest research progress of the molecular mechanism of regulating dairy cow mastitis by mRNA, non-coding RNA (miRNA, lncRNA and circRNA) and bioactive substances through NF-κB signaling pathway, which will provide the reference for the analysis of molecular regulatory network of mastitis, molecular breeding of anti-mastitis, and the development of bioactive drugs for treatment of dairy cow mastitis.

Key words: dairy cow, mastitis, NF-κB signaling pathway, non-coding RNA, bioactive substance

中图分类号:

S823.9

李宇航, 罗仍卓么, 王兴平, 杨箭, 马云, 魏大为. NF-κB信号通路调控奶牛乳腺炎的分子作用机制[J]. 畜牧兽医学报, 2021, 52(10): 2740-2752.

LI Yuhang, LUORENG Zhuoma, WANG Xingping, YANG Jian, MA Yun, WEI Dawei. Molecular Regulatory Mechanism of NF-κB Signaling Pathway Regulating Mastitis in Dairy Cows[J]. Acta Veterinaria et Zootechnica Sinica, 2021, 52(10): 2740-2752.

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