膳食营养成分对犬过敏性皮肤疾病的作用

doi:10.11843/j.issn.0366-6964.2024.09.004

畜牧兽医学报 ›› 2024, Vol. 55 ›› Issue (9): 3777-3791.doi: 10.11843/j.issn.0366-6964.2024.09.004

膳食营养成分对犬过敏性皮肤疾病的作用

王清政¹^,²(), 肖晓杰¹^,²(), 黄福青¹^,²^,⁴, 季新雨¹^,², 张鑫¹^,²^,³^,⁴^,*(), 胡曼丽¹^,²^,³^,⁴^,*()

1. 赣南医科大学，赣南创新与转化医学研究院，赣州 341000
2. 重大疾病新药靶发现及新药创制全国重点实验室，赣州 341000
3. 赣南医学院附属第一医院，心脑血管疾病防治教育部重点实验室，赣州 341000
4. 赣州大健康宠物科学研究院，赣州 341000

收稿日期:2023-12-15 出版日期:2024-09-23 发布日期:2024-09-27
通讯作者: 张鑫,胡曼丽 E-mail:1816791824@qq.com;xxjyonghe@163.com;zhangxin@gmu.edu.cn;humanli@gmu.edu.cn
作者简介:王清政(1999-)，男，河南开封人，硕士生，主要从事宠物食品和动物疾病模型建立研究，E-mail: 1816791824@qq.com
肖晓杰(1999-)，男，江西赣州人，硕士生，主要从事营养与食品卫生和动物疾病模型建立研究，E-mail: xxjyonghe@163.com
第一联系人：
王清政和肖晓杰为同等贡献作者
基金资助:
江西省赣鄱俊才支持计划-主要学科学术和技术带头人培养项目(20232BCJ23087)

The Role of Dietary Nutrients in Allergic Skin Diseases in Dogs

Qingzheng WANG¹^,²(), Xiaojie XIAO¹^,²(), Fuqing HUANG¹^,²^,⁴, Xinyu JI¹^,², Xin ZHANG¹^,²^,³^,⁴^,*(), Manli HU¹^,²^,³^,⁴^,*()

1. Gannan Innovation and Transformation Medical Research Institute, Gannan Medical University, Ganzhou 341000, China
2. State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases, Ganzhou 341000, China
3. Key Laboratory of Cardiovascular Disease Prevention and Control, First Affiliated Hospital of Gannan Medical University, Ganzhou 341000, China
4. Ganzhou Pet Health Science Research Institute, Ganzhou 341000, China

Received:2023-12-15 Online:2024-09-23 Published:2024-09-27
Contact: Xin ZHANG, Manli HU E-mail:1816791824@qq.com;xxjyonghe@163.com;zhangxin@gmu.edu.cn;humanli@gmu.edu.cn

摘要/Abstract

摘要：

犬过敏性皮炎是兽医临床常见的皮肤疾病，它受到多种因素的影响，包括自身遗传和环境过敏原。这些因素导致患犬不同皮肤部位的炎症和瘙痒，严重降低了它们的生活质量和健康状况。除了常规的药物治疗和护理方法外，研究还发现饮食中一些膳食成分在犬皮肤疾病治疗中发挥作用，通过饮食治疗改善皮肤症状逐渐引起了兽医和宠物主人的关注。因此，本文总结了常见的犬过敏性皮肤疾病类别、发病机制和临床症状，并阐述了不同的膳食调控物质，包括必需脂肪酸、水解蛋白、多酚、益生菌、维生素和矿物质对犬过敏性皮肤疾病的作用机制和改善效果的研究进展，旨在为犬过敏性皮肤疾病的研究、饮食设计与产品开发提供参考依据。

关键词: 犬, 皮肤过敏, 饮食治疗, 膳食调控

Abstract:

Canine allergic dermatitis is a common skin disease in the veterinary clinic, and it is affected by several factors, including autogenetic and environmental allergens. These factors cause inflammation and itching in different skin sites of the affected dogs, severely reducing their quality of life and health status. In addition to routine drug treatment and care methods, studies have found that some dietary components in the diet play a role in the treatment of canine skin diseases, and improving skin symptoms through dietary treatment has gradually attracted the attention of veterinarians and pet owners. Therefore, this paper summarizes the common categories, pathogenesis and clinical symptoms of dog allergic skin diseases in dogs, and expounds the research progress of different dietary regulatory substances, including essential fatty acids, hydrolytic proteins, polyphenols, probiotics, vitamins and minerals on dog allergic skin diseases and the improvement effect, aiming to provide reference for the research, diet design and product development of dog allergic skin diseases.

Key words: canine, skin allergy, dietary treatment, dietary regulation

中图分类号:

S858.2927.5

王清政, 肖晓杰, 黄福青, 季新雨, 张鑫, 胡曼丽. 膳食营养成分对犬过敏性皮肤疾病的作用[J]. 畜牧兽医学报, 2024, 55(9): 3777-3791.

Qingzheng WANG, Xiaojie XIAO, Fuqing HUANG, Xinyu JI, Xin ZHANG, Manli HU. The Role of Dietary Nutrients in Allergic Skin Diseases in Dogs[J]. Acta Veterinaria et Zootechnica Sinica, 2024, 55(9): 3777-3791.

参考文献 156

1	古丽沙哈提·孜亚西. 谈犬过敏性皮炎的临床表现及诊疗方法[J]. 畜禽业, 2016, (4): 93- 94.
	GULISHAHATI·Z Y D . To discuss the clinical manifestations and diagnosis and treatment of canine. atopic dermatitis[J]. Livestock and Poultry Industry, 2016, (4): 93- 94.
2	胥辉豪, 李淑敏, 林德贵, 等. 犬猫过敏性皮肤病的诊疗[C]//第六届西部宠物医师大会论文集. 成都: 中国畜牧兽医学会, 2017: 99-104.
	XU H H, LI S M, LIN D G, et al. Diagnosis and treatment of allergic skin diseases in dogs and. cats[C]//The 6th Western Small Animal Veterinarian Congress. Chengdu: Chinese Association of Animal Science and Veterinary Medicine, 2017: 99-104. (in Chinese)
3	曾玉淇, 李德均, 官琼珍, 等. 犬猫皮肤病的研究进展[J]. 今日畜牧兽医, 2021, 37 (3): 62- 65.
	ZENG Y Q , LI D J , GUAN Q Z , et al. Research progress of canine and feline skin diseases[J]. Animal Husbandry and Veterinary Medicine Today, 2021, 37 (3): 62- 65.
4	HENSEL P , SANTORO D , FAVROT C , et al. Canine atopic dermatitis: detailed guidelines for diagnosis and allergen identification[J]. BMC Vet Res, 2015, 11, 196. doi: 10.1186/s12917-015-0515-5
5	SAUVÉ F . Use of topical glucocorticoids in veterinary dermatology[J]. Can Vet J, 2019, 60 (7): 785- 788.
6	VARGO C , BANOVIC F . Is injectable methylprednisolone acetate valuable for treatment of feline hypersensitivity dermatitis?[J]. Vet Dermatol, 2021, 32 (4): 402- 403. doi: 10.1111/vde.13000
7	SANTORO D . Therapies in canine atopic dermatitis: an update[J]. Vet Clin North Am Small Anim Pract, 2019, 49 (1): 9- 26. doi: 10.1016/j.cvsm.2018.08.002
8	MARSELLA R , DOERR K , GONZALES A , et al. Oclacitinib 10 years later: lessons learned and directions for the future[J]. J Am Vet Med Assoc, 2023, 261 (S1): S36- S47. doi: 10.2460/javma.22.12.0570
9	OUTERBRIDGE C A , JORDAN T J M . Current knowledge on canine atopic dermatitis: pathogenesis and treatment[J]. Adv Small Anim Care, 2021, 2, 101- 115. doi: 10.1016/j.yasa.2021.07.004
10	KIECKA A , MACURA B , SZCZEPANIK M . Modulation of allergic contact dermatitis via gut microbiota modified by diet, vitamins, probiotics, prebiotics, and antibiotics[J]. Pharmacol Rep, 2023, 75 (2): 236- 248. doi: 10.1007/s43440-023-00454-8
11	MICHÁL'OVÁ A , TAKÁČOVÁ M , KARASOVÁ M , et al. Comparative study of classical and alternative therapy in dogs with allergies[J]. Animals (Basel), 2022, 12 (14): 1832.
12	ANTURANIEMI J , ZALDÍVAR-LÓPEZ S , SAVELKOUL H F J , et al. The effect of atopic dermatitis and diet on the skin transcriptome in Staffordshire bull terriers[J]. Front Vet Sci, 2020, 7, 552251. doi: 10.3389/fvets.2020.552251
13	DE SANTIAGO M S , ARRIBAS J L G , LLAMAS Y M , et al. Randomized, double-blind, placebo-controlled clinical trial measuring the effect of a dietetic food on dermatologic scoring and pruritus in dogs with atopic dermatitis[J]. BMC Vet Res, 2021, 17 (1): 354. doi: 10.1186/s12917-021-03063-w
14	NUTTALL T J , MARSELLA R , ROSENBAUM M R , et al. Update on pathogenesis, diagnosis, and treatment of atopic dermatitis in dogs[J]. J Am Vet Med Assoc, 2019, 254 (11): 1291- 1300. doi: 10.2460/javma.254.11.1291
15	NOLI C . Assessing quality of life for pets with dermatologic disease and their owners[J]. Vet Clin North Am Small Anim Pract, 2019, 49 (1): 83- 93. doi: 10.1016/j.cvsm.2018.08.008
16	WILHEM S , KOVALIK M , FAVROT C . Breed-associated phenotypes in canine atopic dermatitis[J]. Vet Dermatol, 2011, 22 (2): 143- 149. doi: 10.1111/j.1365-3164.2010.00925.x
17	GRIFFIN C E , DEBOER D J . The ACVD task force on canine atopic dermatitis (XIV): clinical manifestations of canine atopic dermatitis[J]. Vet Immunol Immunopathol, 2001, 81 (3-4): 255- 269. doi: 10.1016/S0165-2427(01)00346-4
18	SHAW S C , WOOD J L N , FREEMAN J , et al. Estimation of heritability of atopic dermatitis in Labrador and Golden retrievers[J]. Am J Vet Res, 2004, 65 (7): 1014- 1020. doi: 10.2460/ajvr.2004.65.1014
19	李常兴, 李雪梅, 张锡宝, 等. 南方汉族人特应性皮炎中间丝聚合蛋白基因多态性检测与分析[J]. 中华医学遗传学杂志, 2011, 28 (5): 572- 574.
	LI C X , LI X M , ZHANG X B , et al. Association of filaggrin gene polymorphism with atopic dermatitis in Southern Chinese Han population[J]. Chinese Journal of Medical Genetics, 2011, 28 (5): 572- 574.
20	WOOD S H , OLLIER W E , NUTTALL T , et al. Despite identifying some shared gene associations with human atopic dermatitis the use of multiple dog breeds from various locations limits detection of gene associations in canine atopic dermatitis[J]. Vet Immunol Immunopathol, 2010, 138 (3): 193- 197. doi: 10.1016/j.vetimm.2010.07.020
21	TENGVALL K , KIERCZAK M , BERGVALL K , et al. Genome-wide analysis in German shepherd dogs reveals association of a locus on CFA 27 with atopic dermatitis[J]. PLoS Genet, 2013, 9 (5): e1003475. doi: 10.1371/journal.pgen.1003475
22	WOOD S H , KE X Y , NUTTALL T , et al. Genome-wide association analysis of canine atopic dermatitis and identification of disease related SNPs[J]. Immunogenetics, 2009, 61 (11-12): 765- 772. doi: 10.1007/s00251-009-0402-y
23	ROQUE J B , O'LEARY C A , DUFFY D L , et al. Atopic dermatitis in west highland white terriers is associated with a 1. 3-Mb region on CFA 17[J]. Immunogenetics, 2012, 64 (3): 209- 217. doi: 10.1007/s00251-011-0577-x
24	BRZOZA Z , GRZESZCZAK W , ROGALA B , et al. PTPN22 polymorphism presumably plays a role in the genetic background of chronic spontaneous autoreactive urticaria[J]. Dermatology, 2012, 224 (4): 340- 345. doi: 10.1159/000339332
25	ROQUE J B , O'LEARY C A , KYAW-TANNER M , et al. Haplotype sharing excludes canine orthologous Filaggrin locus in atopy in west highland white terriers[J]. Anim Genet, 2009, 40 (5): 793- 794. doi: 10.1111/j.1365-2052.2009.01915.x
26	SHIMADA K , YOON J S , YOSHIHARA T , et al. Increased transepidermal water loss and decreased ceramide content in lesional and non-lesional skin of dogs with atopic dermatitis[J]. Vet Dermatol, 2009, 20 (5-6): 541- 546. doi: 10.1111/j.1365-3164.2009.00847.x
27	OLIVRY T . Is the skin barrier abnormal in dogs with atopic dermatitis?[J]. Vet Immunol Immunopathol, 2011, 144 (1-2): 11- 16. doi: 10.1016/j.vetimm.2011.07.014
28	LUGER T , AMAGAI M , DRENO B , et al. Atopic dermatitis: Role of the skin barrier, environment, microbiome, and therapeutic agents[J]. J Dermatol Sci, 2021, 102 (3): 142- 157. doi: 10.1016/j.jdermsci.2021.04.007
29	REITER L V , TORRES S M F , WERTZ P W . Characterization and quantification of ceramides in the nonlesional skin of canine patients with atopic dermatitis compared with controls[J]. Vet Dermatol, 2009, 20 (4): 260- 266. doi: 10.1111/j.1365-3164.2009.00759.x
30	YOON J S , NISHIFUJI K , SASAKI A , et al. Alteration of stratum corneum ceramide profiles in spontaneous canine model of atopic dermatitis[J]. Exp Dermatol, 2011, 20 (9): 732- 736. doi: 10.1111/j.1600-0625.2011.01306.x
31	POPA I , REMOUE N , OSTA B , et al. The lipid alterations in the stratum corneum of dogs with atopic dermatitis are alleviated by topical application of a sphingolipid-containing emulsion[J]. Clin Exp Dermatol, 2012, 37 (6): 665- 671. doi: 10.1111/j.1365-2230.2011.04313.x
32	POPA I , REMOUE N , HOANG L T , et al. Atopic dermatitis in dogs is associated with a high heterogeneity in the distribution of protein-bound lipids within the stratum corneum[J]. Arch Dermatol Res, 2011, 303 (6): 433- 440. doi: 10.1007/s00403-011-1120-5
33	SANTORO D , MARSELLA R , PUCHEU-HASTON C M , et al. Review: pathogenesis of canine atopic dermatitis: skin barrier and host-micro-organism interaction[J]. Vet Dermatol, 2015, 26 (2): 84- e25. doi: 10.1111/vde.12197
34	DAVID BOOTHE W, TARBOX J A, TARBOX M B. Atopic dermatitis: pathophysiology[M]//FORTSON E A, FELDMAN S R, STROWD L C. Management of Atopic Dermatitis: Methods and Challenges. Cham: Springer, 2017: 21-37.
35	DEBOER D J , MARSELLA R . The ACVD task force on canine atopic dermatitis (XII): the relationship of cutaneous infections to the pathogenesis and clinical course of canine atopic dermatitis[J]. Vet Immunol Immunopathol, 2001, 81 (3-4): 239- 249. doi: 10.1016/S0165-2427(01)00345-2
36	MCEWAN N A , MELLOR D , KALNA G . Adherence by Staphylococcus intermedius to canine corneocytes: a preliminary study comparing noninflamed and inflamed atopic canine skin[J]. Vet Dermatol, 2006, 17 (2): 151- 154. doi: 10.1111/j.1365-3164.2006.00503.x
37	SIMOU C , THODAY K L , FORSYTHE P J , et al. Adherence of Staphylococcus intermedius to corneocytes of healthy and atopic dogs: effect of pyoderma, pruritus score, treatment and gender[J]. Vet Dermatol, 2005, 16 (6): 385- 391. doi: 10.1111/j.1365-3164.2005.00484.x
38	MEASON-SMITH C , OLIVRY T , LAWHON S D , et al. Malassezia species dysbiosis in natural and allergen-induced atopic dermatitis in dogs[J]. Med Mycol, 2020, 58 (6): 756- 765. doi: 10.1093/mmy/myz118
39	BOND R , MORRIS D O , GUILLOT J , et al. Biology, diagnosis and treatment of Malassezia dermatitis in dogs and cats: clinical consensus guidelines of the world association for veterinary dermatology[J]. Vet Dermatol, 2020, 31 (1): 73- 77. doi: 10.1111/vde.12834
40	MARTINS L M L . Allergy to fungi in veterinary medicine: Alternaria, dermatophytes and Malassezia pay the Bill![J]. J Fungi (Basel), 2022, 8 (3): 235. doi: 10.3390/jof8030235
41	BLICHARZ L , RUDNICKA L , SAMOCHOCKI Z . Staphylococcus aureus: an underestimated factor in the pathogenesis of atopic dermatitis?[J]. Postepy Dermatol Alergol, 2019, 36 (1): 11- 17. doi: 10.5114/ada.2019.82821
42	NAKAMURA Y , OSCHERWITZ J , CEASE K B , et al. Staphylococcus δ-toxin induces allergic skin disease by activating mast cells[J]. Nature, 2013, 503 (7476): 397- 401. doi: 10.1038/nature12655
43	SAKAMOTO M , ASAHINA R , KAMISHINA H , et al. Transcription of thymic stromal lymphopoietin via toll-like receptor 2 in canine keratinocytes: a possible association of Staphylococcus spp. in the deterioration of allergic inflammation in canine atopic dermatitis[J]. Vet Dermatol, 2016, 27 (3): 184- e46. doi: 10.1111/vde.12301
44	BIZIKOVA P , SANTORO D , MARSELLA R , et al. Review: clinical and histological manifestations of canine atopic dermatitis[J]. Vet Dermatol, 2015, 26 (2): 79- e24. doi: 10.1111/vde.12196
45	MAJEWSKA A , GAJEWSKA M , DEMBELE K , et al. Lymphocytic, cytokine and transcriptomic profiles in peripheral blood of dogs with atopic dermatitis[J]. BMC Vet Res, 2016, 12 (1): 174. doi: 10.1186/s12917-016-0805-6
46	SCHLOTTER Y M , RUTTEN V P M G , RIEMERS F M , et al. Lesional skin in atopic dogs shows a mixed type-1 and type-2 immune responsiveness[J]. Vet Immunol Immunopathol, 2011, 143 (1-2): 20- 26. doi: 10.1016/j.vetimm.2011.05.025
47	FRVH S P , SAIKIA M , EULE J , et al. Elevated circulating Th2 but not group 2 innate lymphoid cell responses characterize canine atopic dermatitis[J]. Vet Immunol Immunopathol, 2020, 221, 110015. doi: 10.1016/j.vetimm.2020.110015
48	HILL P B , OLIVRY T . The ACVD task force on canine atopic dermatitis (V): biology and role of inflammatory cells in cutaneous allergic reactions[J]. Vet Immunol Immunopathol, 2001, 81 (3-4): 187- 198. doi: 10.1016/S0165-2427(01)00310-5
49	MARSELLA R . Advances in our understanding of canine atopic dermatitis[J]. Vet Dermatol, 2021, 32 (6): 547- e151. doi: 10.1111/vde.12965
50	OETJEN L K , MACK M R , FENG J , et al. Sensory neurons co-opt classical immune signaling pathways to mediate chronic itch[J]. Cell, 2017, 171 (1): 217- 228. e13. doi: 10.1016/j.cell.2017.08.006
51	OLIVRY T , MAYHEW D , PAPS J S , et al. Early Activation of Th2/Th22 inflammatory and pruritogenic pathways in acute canine atopic dermatitis skin lesions[J]. J Invest Dermatol, 2016, 136 (10): 1961- 1969. doi: 10.1016/j.jid.2016.05.117
52	FURUE M , FURUE M . Interleukin-31 and pruritic skin[J]. J Clin Med, 2021, 10 (9): 1906. doi: 10.3390/jcm10091906
53	CORNELISSEN C , LVSCHER-FIRZLAFF J , BARON J M , et al. Signaling by IL-31 and functional consequences[J]. Eur J Cell Biol, 2012, 91 (6-7): 552- 566. doi: 10.1016/j.ejcb.2011.07.006
54	MICHELS G M , RAMSEY D S , WALSH K F , et al. A blinded, randomized, placebo-controlled, dose determination trial of lokivetmab (ZTS-00103289), a caninized, anti-canine IL-31 monoclonal antibody in client owned dogs with atopic dermatitis[J]. Vet Dermatol, 2016, 27 (6): 478- e129. doi: 10.1111/vde.12376
55	WATSON A L , FRAY T R , BAILEY J , et al. Dietary constituents are able to play a beneficial role in canine epidermal barrier function[J]. Exp Dermatol, 2006, 15 (1): 74- 81. doi: 10.1111/j.0906-6705.2005.00385.x
56	POPA I , PIN D , REMOUÉ N , et al. Analysis of epidermal lipids in normal and atopic dogs, before and after administration of an oral omega-6/omega-3 fatty acid feed supplement. A pilot study[J]. Vet Res Commun, 2011, 35 (8): 501- 509. doi: 10.1007/s11259-011-9493-7
57	OLIVRY T , MARSELLA R , HILLIER A . The ACVD task force on canine atopic dermatitis (XXIII): are essential fatty acids effective?[J]. Vet Immunol Immunopathol, 2001, 81 (3-4): 347- 362. doi: 10.1016/S0165-2427(01)00316-6
58	SCHUMANN J , BASIOUNI S , GVCK T , et al. Treating canine atopic dermatitis with unsaturated fatty acids: the role of mast cells and potential mechanisms of action[J]. J Anim Physiol Anim Nutr (Berl), 2014, 98 (6): 1013- 1020. doi: 10.1111/jpn.12181
59	MAGRONE T , JIRILLO E . Influence of polyphenols on allergic immune reactions: mechanisms of action[J]. Proc Nutr Soc, 2012, 71 (2): 316- 321. doi: 10.1017/S0029665112000109
60	SINGH A , HOLVOET S , MERCENIER A . Dietary polyphenols in the prevention and treatment of allergic diseases[J]. Clin Exp Allergy, 2011, 41 (10): 1346- 1359. doi: 10.1111/j.1365-2222.2011.03773.x
61	FRAY T R , WATSON A L , CROFT J M , et al. A combination of aloe vera, curcumin, vitamin C, and taurine increases canine fibroblast migration and decreases tritiated water diffusion across canine keratinocytes in vitro[J]. J Nutr, 2004, 134 (8): 2117s- 2119s. doi: 10.1093/jn/134.8.2117S
62	LEE S Y , LEE E , PARK Y M , et al. Microbiome in the gut-skin axis in atopic dermatitis[J]. Allergy Asthma Immunol Res, 2018, 10 (4): 354- 362. doi: 10.4168/aair.2018.10.4.354
63	FANG Z F , LI L Z , ZHANG H , et al. Gut microbiota, probiotics, and their interactions in prevention and treatment of atopic dermatitis: a review[J]. Front Immunol, 2021, 12, 720393. doi: 10.3389/fimmu.2021.720393
64	XIE A N , CHEN A L , CHEN Y Q , et al. Lactobacillus for the treatment and prevention of atopic dermatitis: clinical and experimental evidence[J]. Front Cell Infect Microbiol, 2023, 13, 1137275. doi: 10.3389/fcimb.2023.1137275
65	KIM H , RATHER I A , KIM H , et al. A double-blind, placebo controlled-trial of a probiotic strain lactobacillus sakei probio-65 for the prevention of canine atopic dermatitis[J]. J Microbiol Biotechnol, 2015, 25 (11): 1966- 1969. doi: 10.4014/jmb.1506.06065
66	OHSHIMA-TERADA Y , HIGUCHI Y , KUMAGAI T , et al. Complementary effect of oral administration of Lactobacillus paracasei K71 on canine atopic dermatitis[J]. Vet Dermatol, 2015, 26 (5): 350- e75. doi: 10.1111/vde.12224
67	林德贵. 犬猫过敏性皮肤病的诊疗[C]//第17次全国犬业科技学术研讨会论文集. 太原: 中国畜牧兽医学会, 1994: 48-52.
	LIN D G. Diagnosis and treatment of allergic skin diseases in dogs and cats[C]//The 17th National Symposium on Canine Science and Technology. Taiyuan: Chinese Association of Animal Science and Veterinary Medicine, 1994: 48-52. (in Chinese)
68	SOOD N K , MEKKIB B , SINGLA L D , et al. Cytopathology of parasitic dermatitis in dogs[J]. J Parasit Dis, 2012, 36 (1): 73- 77. doi: 10.1007/s12639-011-0083-y
69	SOUSA C A , HALLIWELL R E W . The ACVD task force on canine atopic dermatitis (XI): the relationship between arthropod hypersensitivity and atopic dermatitis in the dog[J]. Vet Immunol Immunopathol, 2001, 81 (3-4): 233- 237. doi: 10.1016/S0165-2427(01)00344-0
70	WILKERSON M J , BAGLADI-SWANSON M , WHEELER D W , et al. The immunopathogenesis of flea allergy dermatitis in dogs, an experimental study[J]. Vet Immunol Immunopathol, 2004, 99 (3-4): 179- 192. doi: 10.1016/j.vetimm.2004.02.006
71	WUERSCH K , BRACHELENTE C , DOHERR M , et al. Immune dysregulation in flea allergy dermatitis—a model for the immunopathogenesis of allergic dermatitis[J]. Vet Immunol Immunopathol, 2006, 110 (3-4): 311- 323. doi: 10.1016/j.vetimm.2005.10.008
72	SOUSA C A . Fleas, flea allergy, and flea control: a review[J]. Dermatol Online J, 1997, 3 (2): 7.
73	IANNINO F , SULLI N , MAITINO A , et al. Fleas of dog and cat: species, biology and flea-borne diseases[J]. Vet Ital, 2017, 53 (4): 277- 288.
74	THOMSON P , CARREÑO N , NÚÑEZ A . Main mites associated with dermatopathies present in dogs and other members of the canidae family[J]. Open Vet J, 2023, 13 (2): 131- 142. doi: 10.5455/OVJ.2023.v13.i2.1
75	CAO H , LIU Z G . Clinical significance of dust mite allergens[J]. Mol Biol Rep, 2020, 47 (8): 6239- 6246. doi: 10.1007/s11033-020-05613-1
76	MAEDA S , MAEDA S , SHIBATA S , et al. House dust mite major allergen der f 1 enhances proinflammatory cytokine and chemokine gene expression in a cell line of canine epidermal keratinocytes[J]. Vet Immunol Immunopathol, 2009, 131 (3-4): 298- 302. doi: 10.1016/j.vetimm.2009.04.012
77	FERNÁNDEZ-CALDAS E . On mite allergy in dogs and humans[J]. Int Arch Allergy Immunol, 2013, 160 (4): 329- 330. doi: 10.1159/000343492
78	MCCALL C , HUNTER S , STEDMAN K , et al. Characterization and cloning of a major high molecular weight house dust mite allergen (der f 15) for dogs[J]. Vet Immunol Immunopathol, 2001, 78 (3-4): 231- 247. doi: 10.1016/S0165-2427(00)00258-0
79	STAHL J , PAPS J , BÄUMER W , et al. Dermatophagoides farinae house dust mite allergen challenges reduce stratum corneum ceramides in an experimental dog model of acute atopic dermatitis[J]. Vet Dermatol, 2012, 23 (6): 497- e97. doi: 10.1111/j.1365-3164.2012.01114.x
80	OLIVRY T , MUELLER R S . Critically appraised topic on adverse food reactions of companion animals (3): prevalence of cutaneous adverse food reactions in dogs and cats[J]. BMC Vet Res, 2016, 13 (1): 51. doi: 10.1186/s12917-017-0973-z
81	BVSC D G . Muller and Kirk's small animal dermatology[J]. N Z Vet J, 2014, 62 (4): 234. doi: 10.1080/00480169.2013.830281
82	VERLINDEN A , HESTA M , MILLET S , et al. Food allergy in dogs and cats: a review[J]. Crit Rev Food Sci Nutr, 2006, 46 (3): 259- 273. doi: 10.1080/10408390591001117
83	JACKSON H A . Food allergy in dogs and cats; current perspectives on etiology, diagnosis, and management[J]. J Am Vet Med Assoc, 2023, 261 (S1): S23- S29. doi: 10.2460/javma.22.12.0548
84	PUCHEU-HASTON C M , BIZIKOVA P , EISENSCHENK M N C , et al. Review: the role of antibodies, autoantigens and food allergens in canine atopic dermatitis[J]. Vet Dermatol, 2015, 26 (2): 115- e30. doi: 10.1111/vde.12201
85	PICCO F , ZINI E , NETT C , et al. A prospective study on canine atopic dermatitis and food-induced allergic dermatitis in Switzerland[J]. Vet Dermatol, 2008, 19 (3): 150- 155. doi: 10.1111/j.1365-3164.2008.00669.x
86	MUELLER R S , OLIVRY T . Critically appraised topic on adverse food reactions of companion animals (4): can we diagnose adverse food reactions in dogs and cats with in vivo or in vitro tests?[J]. BMC Vet Res, 2017, 13 (1): 275. doi: 10.1186/s12917-017-1142-0
87	HO K K , CAMPBELL K L , LAVERGNE S N . Contact dermatitis: a comparative and translational review of the literature[J]. Vet Dermatol, 2015, 26 (5): 314- e67. doi: 10.1111/vde.12229
88	VOCANSON M , HENNINO A , ROZIÈRES A , et al. Effector and regulatory mechanisms in allergic contact dermatitis[J]. Allergy, 2009, 64 (12): 1699- 1714. doi: 10.1111/j.1398-9995.2009.02082.x
89	CHAMBERLAIN K W . Allergic contact dermatitis[J]. Vet Clin North Am, 1974, 4 (1): 147- 152. doi: 10.1016/S0091-0279(74)50014-0
90	OLIVRY T , PRÉLAUD P , HÉRIPRET D , et al. Allergic contact dermatitis in the dog: principles and diagnosis[J]. Vet Clin North Am Small Anim Pract, 1990, 20 (6): 1443- 1456. doi: 10.1016/S0195-5616(90)50154-0
91	POWELL K , FOSTER C , EVANS S . Environmental risk assessment of veterinary medicines[J]. Vet Rec, 2018, 183 (24): 752.
92	HORSEY J . Environmental dangers of veterinary antiparasitic agents[J]. Vet Rec, 2018, 183 (21): 662. doi: 10.1136/vr.k5025
93	MOOG F , PLICHART G V , BLUA J L , et al. Evaluation of a plant-based food supplement to control flea populations in dogs: a prospective double-blind randomized study[J]. Int J Parasitol Drugs Drug Resist, 2020, 12, 35- 38. doi: 10.1016/j.ijpddr.2020.02.001
94	BANULS D , BRUN J , BLUA J L , et al. A dietary plant extract formulation helps reduce flea populations in cats: a double-blind randomized study[J]. Pharmaceuticals (Basel), 2023, 16 (2): 195. doi: 10.3390/ph16020195
95	JACKSON H A , JACKSON M W , COBLENTZ L , et al. Evaluation of the clinical and allergen specific serum immunoglobulin E responses to oral challenge with cornstarch, corn, soy and a soy hydrolysate diet in dogs with spontaneous food allergy[J]. Vet Dermatol, 2003, 14 (4): 181- 187. doi: 10.1046/j.1365-3164.2003.00338.x
96	PUIGDEMONT A , BRAZÍS P , SERRA M , et al. Immunologic responses against hydrolyzed soy protein in dogs with experimentally induced soy hypersensitivity[J]. Am J Vet Res, 2006, 67 (3): 484- 488. doi: 10.2460/ajvr.67.3.484
97	LOEFFLER A , LLOYD D H , BOND R , et al. Dietary trials with a commercial chicken hydrolysate diet in 63 pruritic dogs[J]. Vet Rec, 2004, 154 (17): 519- 522. doi: 10.1136/vr.154.17.519
98	OLIVRY T , BEXLEY J , MOUGEOT I . Extensive protein hydrolyzation is indispensable to prevent IgE-mediated poultry allergen recognition in dogs and cats[J]. BMC Vet Res, 2017, 13 (1): 251. doi: 10.1186/s12917-017-1183-4
99	YOON J S , NISHIFUJI K , IWASAKI T . Supplementation with eicosapentaenoic acid and linoleic acid increases the production of epidermal ceramides in in vitro canine keratinocytes[J]. Vet Dermatol, 2020, 31 (5): 419- e112. doi: 10.1111/vde.12881
100	WEYLANDT K H , CHIU C Y , GOMOLKA B , et al. Omega-3 fatty acids and their lipid mediators: towards an understanding of resolvin and protectin formation[J]. Prostaglandins Other Lipid Mediat, 2012, 97 (3-4): 73- 82. doi: 10.1016/j.prostaglandins.2012.01.005
101	BAUER J E . Therapeutic use of fish oils in companion animals[J]. J Am Vet Med Assoc, 2011, 239 (11): 1441- 1451. doi: 10.2460/javma.239.11.1441
102	BALIĆ A , VLAŠIĆ D , ŽUŽUL K , et al. Omega-3 versus omega-6 polyunsaturated fatty acids in the prevention and treatment of inflammatory skin diseases[J]. Int J Mol Sci, 2020, 21 (3): 741. doi: 10.3390/ijms21030741
103	ABBA C , MUSSA P P , VERCELLI A , et al. Essential fatty acids supplementation in different-stage atopic dogs fed on a controlled diet[J]. J Anim Physiol Anim Nutr (Berl), 2005, 89 (3-6): 203- 207. doi: 10.1111/j.1439-0396.2005.00541.x
104	ELISIA I , YEUNG M , KOWALSKI S , et al. Omega 3 supplementation reduces C-reactive protein, prostaglandin E₂ and the granulocyte/lymphocyte ratio in heavy smokers: an open-label randomized crossover trial[J]. Front Nutr, 2022, 9, 1051418. doi: 10.3389/fnut.2022.1051418
105	KIRBY N A , HESTER S L , BAUER J E . Dietary fats and the skin and coat of dogs[J]. J Am Vet Med Assoc, 2007, 230 (11): 1641- 1644. doi: 10.2460/javma.230.11.1641
106	LOGAS D , KUNKLE G A . Double-blinded crossover study with marine oil supplementation containing high-dose icosapentaenoic acid for the treatment of canine pruritic skin disease[J]. Vet Dermatol, 1994, 5 (3): 99- 104. doi: 10.1111/j.1365-3164.1994.tb00020.x
107	MUELLER R S , FIESELER K V , FETTMAN M J , et al. Effect of omega-3 fatty acids on canine atopic dermatitis[J]. J Small Anim Pract, 2004, 45 (6): 293- 297. doi: 10.1111/j.1748-5827.2004.tb00238.x
108	BAUER J E . The essential nature of dietary omega-3 fatty acids in dogs[J]. J Am Vet Med Assoc, 2016, 249 (11): 1267- 1272. doi: 10.2460/javma.249.11.1267
109	MILLER W H JR . Nutritional considerations in small animal dermatology[J]. Vet Clin North Am Small Anim Pract, 1989, 19 (3): 497- 511. doi: 10.1016/S0195-5616(89)50057-3
110	MUELLER R S , FETTMAN M J , RICHARDSON K , et al. Plasma and skin concentrations of polyunsaturated fatty acids before and after supplementation with n-3 fatty acids in dogs with atopic dermatitis[J]. Am J Vet Res, 2005, 66 (5): 868- 873. doi: 10.2460/ajvr.2005.66.868
111	MÜLLER M R , LINEK M , LÖWENSTEIN C , et al. Evaluation of cyclosporine-sparing effects of polyunsaturated fatty acids in the treatment of canine atopic dermatitis[J]. Vet J, 2016, 210, 77- 81. doi: 10.1016/j.tvjl.2015.11.012
112	BRUET V , MOSCA M , BRIAND A , et al. Clinical guidelines for the use of antipruritic drugs in the control of the most frequent pruritic skin diseases in dogs[J]. Vet Sci, 2022, 9 (4): 149.
113	STOECKEL K , NIELSEN L H , FUHRMANN H , et al. Fatty acid patterns of dog erythrocyte membranes after feeding of a fish-oil based DHA-rich supplement with a base diet low in n-3 fatty acids versus a diet containing added n-3 fatty acids[J]. Acta Vet Scand, 2011, 53 (1): 57. doi: 10.1186/1751-0147-53-57
114	HALL J A , PICTON R A , SKINNER M M , et al. The (n-3) fatty acid dose, independent of the (n-6) to (n-3) fatty acid ratio, affects the plasma fatty acid profile of normal dogs[J]. J Nutr, 2006, 136 (9): 2338- 2344. doi: 10.1093/jn/136.9.2338
115	MAGALHÃES T R , LOURENÇO A L , GREGÓRIO H , et al. Therapeutic effect of EPA/DHA supplementation in neoplastic and non-neoplastic companion animal diseases: a systematic review[J]. In Vivo, 2021, 35 (3): 1419- 1436. doi: 10.21873/invivo.12394
116	WATSON T D G . Diet and skin disease in dogs and cats[J]. J Nutr, 1998, 128 (12): S2783- s2789. doi: 10.1093/jn/128.12.2783S
117	DUNBAR B L , BIGLEY K E , BAUER J E . Early and sustained enrichment of serum n-3 long chain polyunsaturated fatty acids in dogs fed a flaxseed supplemented diet[J]. Lipids, 2010, 45 (1): 1- 10. doi: 10.1007/s11745-009-3364-9
118	GLOS K , LINEK M , LOEWENSTEIN C , et al. The efficacy of commercially available veterinary diets recommended for dogs with atopic dermatitis[J]. Vet Dermatol, 2008, 19 (5): 280- 287. doi: 10.1111/j.1365-3164.2008.00688.x
119	HENSEL P . Nutrition and skin diseases in veterinary medicine[J]. Clinics in dermatology, 2010, 28 (6): 686- 693. doi: 10.1016/j.clindermatol.2010.03.031
120	SUTO A , SUTO Y , ONOHARA N , et al. Food allergens inducing a lymphocyte-mediated immunological reaction in canine atopic-like dermatitis[J]. J Vet Med Sci, 2015, 77 (2): 251- 254. doi: 10.1292/jvms.14-0406
121	BIZIKOVA P , OLIVRY T . A randomized, double-blinded crossover trial testing the benefit of two hydrolysed poultry-based commercial diets for dogs with spontaneous pruritic chicken allergy[J]. Vet Dermatol, 2016, 27 (4): 289-293, e69-e70. doi: 10.1111/vde.12302
122	BEXLEY J , KINGSWELL N , OLIVRY T . Serum IgE cross-reactivity between fish and chicken meats in dogs[J]. Vet Dermatol, 2019, 30 (1): 25-35, e7-e8. doi: 10.1111/vde.12691
123	MASUDA K , SATO A , TANAKA A , et al. Hydrolyzed diets may stimulate food-reactive lymphocytes in dogs[J]. J Vet Med Sci, 2020, 82 (2): 177- 183. doi: 10.1292/jvms.19-0222
124	SERRA M , BRAZÍS P , FONDATI A , et al. Assessment of IgE binding to native and hydrolyzed soy protein in serum obtained from dogs with experimentally induced soy protein hypersensitivity[J]. Am J Vet Res, 2006, 67 (11): 1895- 1900. doi: 10.2460/ajvr.67.11.1895
125	MARTÍN Á , SIERRA M P , GONZÁLEZ J L , et al. Identification of allergens responsible for canine cutaneous adverse food reactions to lamb, beef and cow's milk[J]. Vet Dermatol, 2004, 15 (6): 349- 356. doi: 10.1111/j.1365-3164.2004.00404.x
126	ROITEL O , BONNARD L , STELLA A , et al. Detection of IgE-reactive proteins in hydrolysed dog foods[J]. Vet Dermatol, 2017, 28 (6): 589- e143. doi: 10.1111/vde.12473
127	SURATANNON N , PRAPANSILP P , SRINARONGSOOK A , et al. Cost-effectiveness of therapeutic infant formulas for cow's milk protein allergy management[J]. Front Nutr, 2023, 10, 1099462. doi: 10.3389/fnut.2023.1099462
128	OLIVRY T , BIZIKOVA P . A systematic review of the evidence of reduced allergenicity and clinical benefit of food hydrolysates in dogs with cutaneous adverse food reactions[J]. Vet Dermatol, 2010, 21 (1): 32- 41. doi: 10.1111/j.1365-3164.2009.00761.x
129	PASTORE S , LULLI D , FIDANZA P , et al. Plant polyphenols regulate chemokine expression and tissue repair in human keratinocytes through interaction with cytoplasmic and nuclear components of epidermal growth factor receptor system[J]. Antioxid Redox Signal, 2012, 16 (4): 314- 328. doi: 10.1089/ars.2011.4053
130	CARBONE M L , LULLI D , PASSARELLI F , et al. Topical plant polyphenols prevent type Ⅰ interferon signaling in the skin and suppress contact hypersensitivity[J]. Int J Mol Sci, 2018, 19 (9): 2652. doi: 10.3390/ijms19092652
131	LEE Y S , RYU H W , YANG W K , et al. A combination of Olea europaea leaf extract and Spirodela polyrhiza extract alleviates atopic dermatitis by modulating immune balance and skin barrier function in a 1-chloro-2, 4-dinitrobenzene-induced murine model[J]. Phytomedicine, 2021, 82, 153407. doi: 10.1016/j.phymed.2020.153407
132	TRESCH M , MEVISSEN M , AYRLE H , et al. Medicinal plants as therapeutic options for topical treatment in canine dermatology?A systematic review[J]. BMC Vet Res, 2019, 15 (1): 174. doi: 10.1186/s12917-019-1854-4
133	TANPRASERTSUK J , TATE D E , SHMALBERG J . Roles of plant-based ingredients and phytonutrients in canine nutrition and health[J]. J Anim Physiol Anim Nutr (Berl), 2022, 106 (3): 586- 613. doi: 10.1111/jpn.13626
134	MASSIMINI M , DALLE VEDOVE E , BACHETTI B , et al. Polyphenols and cannabidiol modulate transcriptional regulation of Th1/Th2 inflammatory genes related to canine atopic dermatitis[J]. Front Vet Sci, 2021, 8, 606197. doi: 10.3389/fvets.2021.606197
135	MARSELLA R , MESSINGER L , ZABEL S , et al. A randomized, double-blind, placebo-controlled study to evaluate the effect of EFF1001, an Actinidia arguta (hardy kiwi) preparation, on CADESI score and pruritus in dogs with mild to moderate atopic dermatitis[J]. Vet Dermatol, 2010, 21 (1): 50- 57. doi: 10.1111/j.1365-3164.2009.00773.x
136	WITZEL-ROLLINS A , MURPHY M , BECVAROVA I , et al. Non-controlled, open-label clinical trial to assess the effectiveness of a dietetic food on pruritus and dermatologic scoring in atopic dogs[J]. BMC Vet Res, 2019, 15 (1): 220. doi: 10.1186/s12917-019-1929-2
137	WATSON A , ROSTAHER A , FISCHER N M , et al. A novel therapeutic diet can significantly reduce the medication score and pruritus of dogs with atopic dermatitis during a nine-month controlled study[J]. Vet Dermatol, 2022, 33 (1): 55-61, e17-e18. doi: 10.1111/vde.13020
138	SINGH S , KAUR I , KARIYAT R . The multifunctional roles of polyphenols in plant-herbivore interactions[J]. Int J Mol Sci, 2021, 22 (3): 1442. doi: 10.3390/ijms22031442
139	ROUSSEAUX A , BROSSEAU C , BODINIER M . Immunomodulation of B lymphocytes by prebiotics, probiotics and synbiotics: application in pathologies[J]. Nutrients, 2023, 15 (2): 269. doi: 10.3390/nu15020269
140	CRAIG J M . Atopic dermatitis and the intestinal microbiota in humans and dogs[J]. Vet Med Sci, 2016, 2 (2): 95- 105. doi: 10.1002/vms3.24
141	MARSELLA R , SANTORO D , AHRENS K . Early exposure to probiotics in a canine model of atopic dermatitis has long-term clinical and immunological effects[J]. Vet Immunol Immunopathol, 2012, 146 (2): 185- 189. doi: 10.1016/j.vetimm.2012.02.013
142	STROMPFOVÁ V , KUBAŠOVÁ I , LAUKOVÁ A . Health benefits observed after probiotic Lactobacillus fermentum CCM 7421 application in dogs[J]. Appl Microbiol Biotechnol, 2017, 101 (16): 6309- 6319. doi: 10.1007/s00253-017-8425-z
143	PAWAR M M , PATTANAIK A K , SINHA D K , et al. Effect of dietary mannanoligosaccharide supplementation on nutrient digestibility, hindgut fermentation, immune response and antioxidant indices in dogs[J]. J Anim Sci Technol, 2017, 59, 11. doi: 10.1186/s40781-017-0136-6
144	FORSBERG A , WEST C E , PRESCOTT S L , et al. Pre- and probiotics for allergy prevention: time to revisit recommendations?[J]. Clin Exp Allergy, 2016, 46 (12): 1506- 1521. doi: 10.1111/cea.12838
145	GUIDI E E A , GRAMENZI A , PERSICO P , et al. Effects of feeding a hypoallergenic diet with a nutraceutical on fecal dysbiosis index and clinical manifestations of canine atopic dermatitis[J]. Animals (Basel), 2021, 11 (10): 2985.
146	UMAR M , SASTRY K S , AL ALI F , et al. Vitamin D and the pathophysiology of inflammatory skin diseases[J]. Skin Pharmacol Physiol, 2018, 31 (2): 74- 86. doi: 10.1159/000485132
147	KLINGER C J , HOBI S , JOHANSEN C , et al. Vitamin D shows in vivo efficacy in a placebo-controlled, double-blinded, randomised clinical trial on canine atopic dermatitis[J]. Vet Rec, 2018, 182 (14): 406. doi: 10.1136/vr.104492
148	HOUGHTON C C , LEW S Q . Long-term hypervitaminosis D-induced hypercalcaemia treated with glucocorticoids and bisphosphonates[J]. BMJ Case Rep, 2020, 13 (4): e233853. doi: 10.1136/bcr-2019-233853
149	BERARDESCA E , CAMELI N . Vitamin E supplementation in inflammatory skin diseases[J]. Dermatol Ther, 2021, 34 (6): e15160. doi: 10.1111/dth.15160
150	PLEVNIK KAPUN A , SALOBIR J , LEVART A , et al. Plasma and skin vitamin E concentrations in canine atopic dermatitis[J]. Vet Q, 2013, 33 (1): 2- 6. doi: 10.1080/01652176.2012.758395
151	PLEVNIK KAPUN A , SALOBIR J , LEVART A , et al. Vitamin E supplementation in canine atopic dermatitis: improvement of clinical signs and effects on oxidative stress markers[J]. Vet Rec, 2014, 175 (22): 560. doi: 10.1136/vr.102547
152	BEHERA S K , DIMRI U , SINGH S K , et al. The curative and antioxidative efficiency of ivermectin and ivermectin+vitamin E-selenium treatment on canine Sarcoptes scabiei infestation[J]. Vet Res Commun, 2011, 35 (4): 237- 244. doi: 10.1007/s11259-011-9468-8
153	WESSELS I , MAYWALD M , RINK L . Zinc as a gatekeeper of immune function[J]. Nutrients, 2017, 9 (12): 1286. doi: 10.3390/nu9121286
154	OGAWA Y , KINOSHITA M , SHIMADA S , et al. Zinc in keratinocytes and langerhans cells: relevance to the epidermal homeostasis[J]. J Immunol Res, 2018, 2018, 5404093.
155	MCFADDEN R A , HEINRICH N A , HAARSTAD A C , et al. A double-blinded, randomized, controlled, crossover evaluation of a zinc methionine supplement as an adjunctive treatment for canine atopic dermatitis[J]. Vet Dermatol, 2017, 28 (6): 569.e138. doi: 10.1111/vde.12466
156	PEREIRA A M , MAIA M R G , FONSECA A J M , et al. Zinc in dog nutrition, health and disease: a review[J]. Animals (Basel), 2021, 11 (4): 978.

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膳食营养成分对犬过敏性皮肤疾病的作用

The Role of Dietary Nutrients in Allergic Skin Diseases in Dogs

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