种养循环模式中黏菌素抗性基因mcr-1的归趋

doi:10.11843/j.issn.0366-6964.2025.10.008

畜牧兽医学报 ›› 2025, Vol. 56 ›› Issue (10): 4851-4862.doi: 10.11843/j.issn.0366-6964.2025.10.008

种养循环模式中黏菌素抗性基因mcr-1的归趋

冉红丽¹(), 温馨¹, 胥娇娇¹, 陈龙海¹, 吴银宝¹^,²^,³^,⁴^,*()

1. 华南农业大学动物科学学院, 广州 510642
2. 猪禽种业全国重点实验室, 广州 510642
3. 国家生猪种业工程技术研究中心, 广州 510642
4. 广东省农业动物基因组学与分子育种重点实验室, 广州 510642

收稿日期:2024-12-24 出版日期:2025-10-23 发布日期:2025-11-01
通讯作者: 吴银宝 E-mail:3350656529@qq.com;wuyinbao@scau.edu.cn
作者简介:冉红丽(2003-), 女, 土家族, 贵州铜仁人, 本科生, 主要从事智慧养殖研究, E-mail: 3350656529@qq.com
基金资助:
国家自然科学基金项目(32402821);国家博士后科学基金面上资助(2024M760976);广东省基础与应用基础研究基金资助项目(2023A1515110839);国家现代农业产业技术体系(CARS-40)

Fate of the Colistin Resistance Gene mcr-1 in Crop-Livestock Integrated Farming Systems

RAN Hongli¹(), WEN Xin¹, XU Jiaojiao¹, CHEN Longhai¹, WU Yinbao¹^,²^,³^,⁴^,*()

1. College of Animal Science, South China Agricultural University, Guangzhou 510642, China
2. State Key Laboratory of Swine and Poultry Breeding Industry, Guangzhou 510642, China
3. National Engineering Research Center for Breeding Swine Industry, Guangzhou 510642, China
4. Guangdong Provincial Key Laboratory of Agro-Animal Genomics and Molecular Breeding, Guangzhou 510642, China

Received:2024-12-24 Online:2025-10-23 Published:2025-11-01
Contact: WU Yinbao E-mail:3350656529@qq.com;wuyinbao@scau.edu.cn

摘要/Abstract

摘要：

抗性基因mcr-1作为介导细菌对"最后一道防线"抗生素黏菌素产生耐药性的关键遗传元件, 一经发现就成为当前研究热点之一, 对公共卫生构成潜在威胁。本文旨在探讨种养循环模式下黏菌素抗性基因mcr-1的归趋。本文首先概述了mcr-1的抗性机制、水平传播、适应性代价和补偿性进化, 然后介绍了mcr-1在种养循环系统中的赋存、转归与水平传播特征, 并探讨了影响其传播的关键因素, 最后提出相应的防控措施, 以期为循环农业的高质量发展和公共卫生安全提供参考。

关键词: 种养循环, 抗性基因, mcr-1, 归趋, 水平传播, 黏菌素

Abstract:

The resistance gene mcr-1, as a key genetic element mediating bacterial resistance to "last-resort" antibiotic colistin, has become a research hotspot since its discovery and poses a potential threat to public health. This paper aims to investigate the fate of colistin resistance gene mcr-1 in the planting-breeding cycling system. First, we summarize the resistance mechanisms, horizontal gene transfer, fitness costs, and compensatory evolution of mcr-1. Subsequently, we examine its occurrence, fate, and horizontal transmission characteristics in the planting-breeding cycling system, along with the key factors influencing its dissemination. Finally, we propose corresponding control measures, providing insights for high-quality development of circular agriculture and public health security.

Key words: crop-livestock integrated farming system, antibiotic resistance gene, mcr-1, fate, horizontal gene transfer, colistin

中图分类号:

S851

冉红丽, 温馨, 胥娇娇, 陈龙海, 吴银宝. 种养循环模式中黏菌素抗性基因mcr-1的归趋[J]. 畜牧兽医学报, 2025, 56(10): 4851-4862.

RAN Hongli, WEN Xin, XU Jiaojiao, CHEN Longhai, WU Yinbao. Fate of the Colistin Resistance Gene mcr-1 in Crop-Livestock Integrated Farming Systems[J]. Acta Veterinaria et Zootechnica Sinica, 2025, 56(10): 4851-4862.

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样本来源 Sample sources	样本种类 Sample type	样本数量 Sample size	采样时间 Sampling time	地域分布 Geographical distribution	检出率或丰度 Detection rate or abundance
畜禽肠道 Livestock intestinal tract	鸡Chicken	275	2021年前	中国	5.8%^[37]
	鸭Duck	15	2024年	中国(广东)	100%^[38]
	猪Pig	325	2023年	中国(上海)	41.8%^[39]
	猪Pig	804	2012—2014年	中国(广东、广西、湖南、江西)	20.6%^[3]
	牛Cattle	118	2018年	中国(辽宁、陕西、贵州和湖南)	0.02 copies/16S rRNA gene copies^[36]
畜禽粪便 Livestock manure	鸡粪Chicken manure	202	2021年前	英国、德国、保加利亚、意大利、法国、西班牙、波兰、比利时、荷兰	7.4%^[37]
	鸭粪Duck manure	66	2022年	中国(青岛)	24.2%^[40]
	猪粪Pig manure	753	2019年	中国(武汉)	59.6%^[41]
	猪粪Pig manure	57	2021年	西班牙	7.0%^[42]
	牛粪Cattle manure	51	2019年	中国(江苏、浙江)	31.3%^[34]
	牛粪Cattle manure	152	2021年	西班牙	8.6%^[42]
畜禽污水 Livestock sewage	鸡场Chicken farm	53	2020年	中国东部	69.9%^[43]
	鸭场Duck farm	143	2017年	中国(广东)	22.4%^[44]
	猪场Pig farm	412	2016—2019年	中国(北京、河南、山东、四川和浙江)	>85%^[45]
	猪场Pig farm	65	2019年	中国(广东、福建、江苏、山东、河南和辽宁)	64.6%^[46]
	猪场Pig farm	/	2016年	中国(武汉)	5.0×10⁴ copies·L^-1^[47]

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种养循环模式中黏菌素抗性基因mcr-1的归趋

Fate of the Colistin Resistance Gene mcr-1 in Crop-Livestock Integrated Farming Systems

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