猪流行性腹泻病毒的天然免疫逃避机制及其防控研究进展

doi:10.11843/j.issn.0366-6964.2025.06.006

畜牧兽医学报 ›› 2025, Vol. 56 ›› Issue (6): 2590-2599.doi: 10.11843/j.issn.0366-6964.2025.06.006

猪流行性腹泻病毒的天然免疫逃避机制及其防控研究进展

吴超¹(), 明文含¹, 卢姝婉¹, 杨彩梅¹, 刘金松², 马翔¹, 张瑞强¹^,*()

1. 浙江农林大学动物科技学院·动物医学院，浙江省畜禽绿色生态健康养殖应用技术研究重点实验室，动物健康互联网检测技术浙江省工程实验室，临安 311300
2. 浙江省绿色动物保健品重点农业企业研究院，浙江惠嘉生物科技股份有限公司，安吉 313300

收稿日期:2024-11-19 出版日期:2025-06-23 发布日期:2025-06-25
通讯作者: 张瑞强 E-mail:jt32208@163.com;zrq1034@163.com
作者简介:吴超(1999-)，男，安徽六安人，硕士生，主要从事动物肠道健康调控方面的研究，E-mail: jt32208@163.com
基金资助:
浙江省“尖兵领雁+X”研发攻关计划项目(2024C04016)

Innate Immune Evasion Mechanisms of Porcine Epidemic Diarrhea Virus and Advances in Prevention and Control Strategies

WU Chao¹(), MING Wenhan¹, LU Shuwan¹, YANG Caimei¹, LIU Jinsong², MA Xiang¹, ZHANG Ruiqiang¹^,*()

1. Zhejiang Provincial Engineering Laboratory for Animal Health Inspection & Internet Technology, Key Laboratory of Applied Technology on Green-Eco-Healthy Animal Husbandry of Zhejiang Province, College of Animal Science and Technology, College of Veterinary Medicine, Zhejiang Agricultural and Forestry University, Lin' an 311300, China
2. Zhejiang Vegamax Biotechnology Co., Ltd., Vegamax Green Animal Health Products Key Agricultural Enterprise Research Institute, Anji 313300, China

Received:2024-11-19 Online:2025-06-23 Published:2025-06-25
Contact: ZHANG Ruiqiang E-mail:jt32208@163.com;zrq1034@163.com

摘要/Abstract

摘要：

猪流行性腹泻病(porcine epidemic diarrhea，PED)是由猪流行性腹泻病毒(porcine epidemic diarrhea virus，PEDV)引起的一种以呕吐、脱水和腹泻为主要特征的急性、高度接触性肠道传染病。近年来，由于PEDV变异毒株的不断出现，许多国家的养猪业遭受了巨大的经济损失。由此，探究PEDV的致病机制及其有效防控措施，可为生猪养殖提供重要保障。本文综述了PEDV在抑制干扰素产生，调控细胞凋亡、细胞自噬、细胞焦亡与炎症反应过程中的逃避机制，分析了PEDV的疫苗和营养防控研究进展，旨在为PED的有效控制提供理论参考。

关键词: 猪流行性腹泻病毒, 逃逸机制, 防控措施

Abstract:

Porcine epidemic diarrhea (PED) is an acute, highly contagious intestinal infectious disease caused by porcine epidemic diarrhea virus (PEDV), characterized primarily by vomiting, dehydration, and diarrhea. In recent years, the emergence of variant PEDV strains has led to significant economic losses in the pig farming industry in many countries. Therefore, investigating the pathogenic mechanisms of PEDV and identifying effective prevention and control measures are essential to ensuring the health and productivity of pig farming. This review summarizes the mechanisms by which PEDV evades host immune responses, including the inhibition of interferon production and the regulation of apoptosis, autophagy, pyroptosis, and inflammatory responses. Additionally, it discusses the progress in vaccine development and nutritional interventions aimed at controlling PEDV, providing a theoretical foundation for the effective control of PED.

Key words: porcine epidemic diarrhea virus, escape mechanism, prevention and control measures

中图分类号:

S852.65

吴超, 明文含, 卢姝婉, 杨彩梅, 刘金松, 马翔, 张瑞强. 猪流行性腹泻病毒的天然免疫逃避机制及其防控研究进展[J]. 畜牧兽医学报, 2025, 56(6): 2590-2599.

WU Chao, MING Wenhan, LU Shuwan, YANG Caimei, LIU Jinsong, MA Xiang, ZHANG Ruiqiang. Innate Immune Evasion Mechanisms of Porcine Epidemic Diarrhea Virus and Advances in Prevention and Control Strategies[J]. Acta Veterinaria et Zootechnica Sinica, 2025, 56(6): 2590-2599.

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猪流行性腹泻病毒的天然免疫逃避机制及其防控研究进展

Innate Immune Evasion Mechanisms of Porcine Epidemic Diarrhea Virus and Advances in Prevention and Control Strategies

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