犬多层螺旋CT肝多期增强扫描技术研究

doi:10.11843/j.issn.0366-6964.2022.10.037

摘要/Abstract

摘要： 本试验旨在确定犬肝多期增强扫描造影剂使用剂量、注射速率及最佳延迟时间。选取不同的碘海醇剂量（500、575、650 mg·kg^-1，以I含量计）及速率（2、3 mL·s^-1）对犬进行造影，动态扫描，计算造影前后主动脉、门静脉、肝实质CT增强值，确定最佳造影剂剂量及注射速率。然后采用最佳造影剂剂量和注射速率对不同体型的犬进行造影，动态扫描后绘制时间-密度曲线，统计主动脉、门静脉、肝实质的达峰时间，计算达峰时间和注射时间的差值（Δt_AO/Δt_SP/Δt_L），确定各期最佳扫描延迟时间。研究结果显示，当采用575 mg·kg^-1、3 mL·s^-1的造影剂剂量和注射速率时得到的主动脉、门静脉、肝实质CT增强值较高，可获得较好的增强效果。通过时间-密度曲线分别计算小、中、大3种体型犬的Δt_AO分别为7、9、4 s，Δt_SP分别为21、23、17 s，Δt_L分别为41、44、34 s，各期最佳扫描延迟时间可用公式“注射时间+Δt_ROI-1/2扫描时间”计算得到。通过临床病例验证，本试验使用的造影剂剂量（575 mg·kg^-1）、注射速率（3 mL·s^-1）及延迟时间（“注射时间+Δt_AO/Δt_SP/Δt_L-1/2扫描时间”）临床效果较好，可应用于犬肝疾病的CT造影检查。

关键词: 犬, 肝, CT, 多期增强, 碘海醇, 注射速率, 延迟时间

Abstract: The aim of this research was to determine the dose and injection rate of contrast medium and the optimal delay time for multi-phase contrast-enhanced scanning of liver in dogs. Different iohexol doses (500, 575 and 650 mg·kg^-1, calculated based on I content) and injection rates (2 and 3 mL·s^-1) were selected for dynamic scanning modality in dog. The CT enhancement values of aorta, portal vein and liver parenchyma were respectively calculated to determine the optimal dose and injection rate of contrast medium. Then the dogs of different sizes were scanned using the optimal contrast medium dose and injection rate. The time-density curves of aorta, portal vein and liver parenchyma were drawn after dynamic scanning. The peak arrival times of aorta, portal vein and liver parenchyma were counted, and the difference between the peak arrival time and injection time (Δt_AO/Δt_SP/Δt_L) were calculated to determine the optimal scanning delay time of each phase. The results showed that the CT enhancement values of aorta, portal vein and liver parenchyma were higher with a dose of 575 mg·kg^-1 at an injection rate of 3 mL·s^-1. Perfect contrast enhancement effect could be obtained in these situations. The Δt_AO values of small, medium and large size dogs were 7, 9 and 4 s, Δt_SP were 21, 23 and 17 s, and Δt_L were 41, 44 and 34 s, according to the time density curves. The optimal scan delay times in each phase could be calculated by the equation "injection time+Δt_ROI-1/2 scan time". It has been verified in clinical cases that the dose of contrast medium (I, 575 mg·kg^-1), injection rate (3 mL·s^-1) and delay times ("injection time +Δt_AO/Δt_SP/Δt_L-1/2 scan time") used in this research had better clinical contrast enhancement effects on liver image and can be applied to contrast-enhancement CT diagnosis of liver diseases in dogs.

Key words: dogs, liver, CT, multiphasic enhancement, iohexol, injection rate, delay time

中图分类号:

S854.7

廖云, 郭译文, 李翎旭, 苏泽楠, 蒋怀德, 杨德吉, 赵艳兵, 姚大伟. 犬多层螺旋CT肝多期增强扫描技术研究[J]. 畜牧兽医学报, 2022, 53(10): 3667-3674.

LIAO Yun,GUO Yiwen,LI Lingxu,SU Zenan,JIANG Huaide,YANG Deji,ZHAO Yanbing,YAO Dawei. Multiphasic Contrast-enhanced Multi-slice Spiral CT Scanning Technology of Liver in Dogs[J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53(10): 3667-3674.

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