畜牧兽医学报 ›› 2021, Vol. 52 ›› Issue (12): 3335-3345.doi: 10.11843/j.issn.0366-6964.2021.012.002
赵磊, 康晓龙*
收稿日期:
2021-04-19
出版日期:
2021-12-25
发布日期:
2021-12-22
通讯作者:
康晓龙,主要从事动物基因组与分子育种研究,E-mail:kangxl9527@126.com
作者简介:
赵磊(1997-),男,陕西榆林人,硕士生,主要从事动物遗传育种研究,E-mail:zl18629227731@163.com
基金资助:
ZHAO Lei, KANG Xiaolong*
Received:
2021-04-19
Online:
2021-12-25
Published:
2021-12-22
摘要: 超级增强子是一类包含多个普通增强子的大簇,主要富集高密度的转录因子、辅助因子及增强子相关表观修饰位点。与普通增强子相比,超级增强子具有更高的转录激活能力,在细胞类型特异性发育、分化以及肿瘤的发展进程中发挥关键作用。研究超级增强子在基因转录过程中的作用机制,对于揭示哺乳动物表型性状的分子机理具有十分重要的生物学意义。本文概述了超级增强子的概念、特性及鉴定方法,总结了超级增强子发挥作用的主要机制,最后对超级增强子调控动物重要表型的研究进展进行综述,并且结合超级增强子在哺乳动物方面的最新研究进展,讨论了其在哺乳类动物中的应用前景,旨在为超级增强子在动物重要性状表型研究中提供参考。
中图分类号:
赵磊, 康晓龙. 超级增强子调控基因表达的生物学作用及其在哺乳动物中的应用前景[J]. 畜牧兽医学报, 2021, 52(12): 3335-3345.
ZHAO Lei, KANG Xiaolong. The Biological Role of Super Enhancers in Regulating Gene Expression and Their Application Prospects in Mammals[J]. Acta Veterinaria et Zootechnica Sinica, 2021, 52(12): 3335-3345.
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