H6N6亚型禽流感病毒广东分离株分子遗传演化分析

doi:10.11843/j.issn.0366-6964.2014.06.018

Abstract

Abstract:

Two H6N6 subtype avian influenza viruses (AIV)，A/Duck/Guangdong/C45/2010(H6N6) and A/Duck/Guangdong/C120/2011(H6N6)，were isolated from the live-poultry markets of Guangdong during 2010 to 2011.The sequence analysis of the hemagglutinin (HA) gene showed that the isolates were categorized as low pathogenic AIV，with the typical HA cleavage site of P-Q-I-E-T-R-G.The HA gene of the two isolates was closely related to that of A/Duck/Guangxi/GXd-5/2010(H6N1).The NA genes of the two isolates were closely related to that of A/Duck/Fujian/3242/2007(H6N6) and A/Duck/Fujian/6159/2007(H6N6)，respectively.The phylogenic analysis indicated that the eight genes of the two isolates belonged to the Eurasian avian lineage.The HA and NP genes of them belonged to ST2853-like lineage and HN573-like lineage，respectively.However，the other genes of them belonged to ST339-like lineage.Those indicated that the two isolates were recombinant viruses resulted from different genotype viruses.Therefore，we should focus on studying the pathogenic evolution and genetic variation of H6N6 subtype AIV to prevent and control the AIV.

Key words: avian influenza virus, H6N6, phylogenic analysis

CLC Number:

S852.659.5

ZHANG Shuo，LIN Hong-wen，YUAN Run-yu，SONG Ya-fen，CUI Jin，GONG Lang，QU Xiao-yun，HAN Fei，WU Xiao-wei，XU Cheng-gang，LIAO Ming，JIAO Pei-rong. Phylogenetic Analysis of H6N6 Subtype Avian Influenza Virus from Guangdong[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2014, 45(6): 989-996.

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Phylogenetic Analysis of H6N6 Subtype Avian Influenza Virus from Guangdong

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