miR-184及miR-205在绵羊不同生长时期毛囊及其他组织中的表达研究

Abstract

Abstract:

In order to study the roles of miR-184 and miR-205 in hair follicle development of sheep, the expression of miR-184 and miR-205 at three different developmental stages of hair follicle of sheep was detected by QPCR. The precursors of the two microRNAs was predicted and the sequences were mapped to genome of sheep. Furthermore target genes and pathways of the two microRNAs were predicted. The results indicated that the expression of miR-184 in hair follicle tissue showed increasing trend from anagen to telogen. However, the miR-205 was upregulated from anagen to catagen, and then downregulated from catagen to telogen. The expression of miR-205 was highest in catagen. miR-184 and miR-205 both express in many different tiusses. Moreover, the candidate target genes of the two microRNAs are involved in 15 different pathways and miR-184 and miR-205 probably regulate the hair follicle development through Wnt signaling pathway.

CLC Number:

S826
S813.3

TANG Xiao-hui, LIU Guang-bin, DU Xiao-yong, CAO Jian-hua, LI Xin-yun, LUO Zhang, YU Mei, ZHAO Shu-hong. The Study on Expression of miR-184 and miR-205 at Different Developmental Stages of Hair Follicle and Other Tissues of Sheep[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, doi: .

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The Study on Expression of miR-184 and miR-205 at Different Developmental Stages of Hair Follicle and Other Tissues of Sheep

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