Acta Veterinaria et Zootechnica Sinica ›› 2025, Vol. 56 ›› Issue (6): 2525-2536.doi: 10.11843/j.issn.0366-6964.2025.06.001

• Review • Previous Articles     Next Articles

Research Progress on the Regulation of Uterine Involution in Ewes by the Hypothalamic-Pituitary-Gonadal Axis

MA Qingling1,2(), WANG Zhiyou2, HOU Shengzhen1, YANG Chao1,*()   

  1. 1. State Key Laboratory of Sanjiangyuan Ecology and Plateau Agriculture and Animal Husbandry, Qinghai University, Xining 810016, China
    2. College of Agriculture and Animal Husbandry, Qinghai University, Xining 810016, China
  • Received:2024-11-21 Online:2025-06-23 Published:2025-06-25
  • Contact: YANG Chao E-mail:2923161984@qq.com;yangchao@qhu.edu.cn

Abstract:

Uterine involution represents a crucial component of the reproductive process in animals, with the extent of involution being a key determinant of whether a female animal can achieve subsequent pregnancy. The completion of uterine involution in female animals postpartum is influenced by a variety of factors, including nutrition, postpartum care, and the season of parturition. In ruminants, this process is primarily regulated by the hypothalamic-pituitary-gonadal axis (HPGA). However, current research on the mechanisms underlying uterine involution in ewes remains fragmented, and the specific regulatory pathways of the HPGA in this context are not yet fully elucidated. This review aims to comprehensively examine the mechanisms of uterine involution in ewes, the factors influencing this process, and the role of the HPGA. It is intended to provide a foundational reference for a deeper understanding of the significance of the HPGA in uterine involution in ewes and to offer a theoretical basis for future research into the regulatory mechanisms of the HPGA in this area.

Key words: ewe, uterine involution, hypothalamic-pituitary-gonadal axis, regulatory mechanism

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