RNA结合蛋白ELAVL1的功能及其调控病毒复制的研究进展

doi:10.11843/j.issn.0366-6964.2024.05.010

Abstract

Abstract: Embryonic lethal abnormal vision like 1 (ELAVL1), also called human antigen R (HuR).It is a typical RNA binding protein (RBP) that binds to the AU-rich element (ARE) in the 3'untranslated element (3'UTR) and plays an important role in the process of mRNA transcription and translation. ELAVL1 has a wide range of functions and can regulate the occurence and development, apoptosis, migration, and invasion of tumors, making it the key target for many cancer treatments. It can also participate in the regulation of protein and mRNA levels encoding organ development and tissue homeostasis. Many studies have also shown that ELAVL1 regulates viral replication through post-transcriptional regulation and post-translational modification. This review summarizes the biological characteristics, functions, regulatory mechanisms of ELAVL1 and its regulatory role in the process of virus replication, aiming to provide a theoretical reference for further studies on the interaction between ELAVL1 and virus replication in livestock and poultry.

Key words: ELAVL1, RNA binding protein, virus, regulatory mechanism

CLC Number:

S855.3

YU Zuhua, GAO Mengru, QI Zhiying, ZHANG Jingyu, HE Lei, CHEN Jian, DING Ke. Research Progress on the Function of RNA Binding Protein ELAVL1 and Its Regulation of Viral Replication[J]. Acta Veterinaria et Zootechnica Sinica, 2024, 55(5): 1914-1925.

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Research Progress on the Function of RNA Binding Protein ELAVL1 and Its Regulation of Viral Replication

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