β-折叠抗菌肽的研发及应用策略

doi:10.11843/j.issn.0366-6964.2022.08.008

Abstract

Abstract: The abuse of antibiotics has led to the problem of bacterial resistance more and more serious in the world, which has posed a great threat to the health of human beings and livestock as well as the development of animal husbandry. Antimicrobial peptides (AMPs), which have diverse functions and are not tend to cause bacterial resistance, have gradually developed into potential substitutes of antibiotics. β-sheet structure is a major secondary element constituting the classification of AMPs, which usually maintains the structural stability through one or more disulfide bonds. Compared with the widely studied α-helical AMP, they are believed to have stronger resistance to enzymolysis and higher cell selectivity. This review briefly introduces the natural sources and antibacterial mechanism of β-sheet AMPs, and sorts out some common molecular design methods and application strategies. The content obtained here can provide novel ideas for the research and application of β-sheet AMPs.

Key words: β-sheet antimicrobial peptides, molecular design, antibacterial mechanism, application strategy

CLC Number:

SHAO Changxuan, DANG Ankai, ZHAN Zhaohan, LAI Zhenheng, ZHU Yongjie, SHAN Anshan. Development and Application Strategy of Beta Sheet Antimicrobial Peptides[J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53(8): 2490-2501.

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Development and Application Strategy of Beta Sheet Antimicrobial Peptides

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