Abstract: Seven muscle and adipose related miRNAs, including miR-1, miR-133, miR-24, miR-122, miR-103, miR-143 and let7 were selected to analyze their expression and target expression profiles. Muscles RNA from back and hind leg muscle of 4 cashmere goats were extracted, after reversetranscription, SYBR TaqMan PCR was used to detect gene expression, and miRNA target expression profiles were got by PAGE electrophoresis and MiRNA Targets Figure Print (MTFP) technique. The result showed that the expression of miRNA were as follows:miR-1>miR-133>miR-24>let7>miR-143>miR-103>miR-122, the expression patterns of miR-1 and miR-133 were similar,and the expression levels of all miRNAs in adult goat were higher than that in lamb; moreover, the difference of miRNAs expression levels were also affected by gender, and they had relationship with number and expression levels of target genes. 10 target genes in 5 miRNAs were sequenced and Blast annotation, which coded proteins related to signal transduction, cell cycle, and so on. The expression analysis of 7 miRNAs and their target genes showed differences and similarities between muscle development related miRNAs and adipose development related miRNAs in cashmere goat skeletal muscle, which were favorable to the research for meat quality related genes in cashmere goat.