Abstract: According to the chicken BMP4 gene sequence in GenBank, a pair of specific primers were designed, and total RNA extracted from the dorsal skin of Wanxi White goose at embryonic day 12 was used to amplify a partial cDNA encoding BMP4 with RT-PCR technique. The PCR product was cloned into pGEM-T easy vector, and the recombinant plasmid was digested with restriction endonuclease, and then the positive plasmid was sent to be sequenced. After being aligned with the related cDNA sequences of Gallus gallus, Rattus norvegicus, Mus musculus, Homo sapiens and Pan troglodytes, some mutations were found. When being translated into amino acid sequence, some mutations in BMP4 among goose and other species were also observed. These mutations may cause the differentiation in the morphology between the feathers of the fowl and the hairs of the mammal.