禽源多杀性巴氏杆菌流行趋势及耐药性研究进展

doi:10.11843/j.issn.0366-6964.2025.12.013

Abstract

Abstract: Avian pathogenic Pasteurella multocida, a widespread Gram-negative short bacillus, causes avian cholera and leads to significant economic losses on the global poultry industry. The long-term reliance on antibiotic treatment for avian cholera has led to an increase in antibiotic-resistant bacteria in poultry. This article compiles data on the prevalence and antibiotic resistance of avian P. multocida from 17 regions domestically and internationally over the past two decades. Statistics indicate that avian P. multocida is prevalent across all continents, particularly in areas with common poultry farming and consumption, where the prevalence rate exceeds 43.50%. Domestically, it is highly prevalent in Jiangsu Province (53.73%) and Guangdong Province (48.97%), with rates over 48%. Genomic analysis of avian Pasteurella multocida in the database revealed a total of 31 sequence types (STs), among which ST159 (115/733,15.69%) and ST128 (82/733,11.19%) exhibited host preferences for chickens (n=109) and ducks (n=65), respectively. Both domestic and international studies have found high resistance rates to commonly used antibiotics, especially kanamycin (99/165, 60%), chloramphenicol (124/230,53.91%), and tetracycline (258/556,46.40%). Genome analysis has detected 29 resistance genes covering eight classes of antibiotics, with sul2 (13.64%) and tet(B) (10.64%) being the most prevalent. In conclusion, there are differences in the prevalence of avian P. multocida between domestic and international regions, and resistance rates to multiple antibiotics are high. Prevention and control measures such as vaccines and bacteriophages can be implemented based on local prevalence characteristics, and the use of antibiotics with high resistance should be reduced to achieve effective treatment and establish green, sustainable farming practices.

Key words: avian Pasteurella multocida, antimicrobial resistance, genomic analysis

CLC Number:

S852.61

MIAO Fengcheng, LONG Xiaoqian, LI Zhiyu, SHEN Yao, LÜ Kaikai, JIAN Huafeng, LI Junxing, LI Shuangmao, YANG Hua, MA Jiangang, DAI Bing. Research Progress on the Epidemic Trend and Antimicrobial Resistance of Avian Pasteurella multocida[J]. Acta Veterinaria et Zootechnica Sinica, 2025, 56(12): 6080-6093.

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Research Progress on the Epidemic Trend and Antimicrobial Resistance of Avian Pasteurella multocida

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