畜禽m6A甲基化修饰及营养调控研究进展

doi:10.11843/j.issn.0366-6964.2025.09.008

Abstract

Abstract:

N6-methyladenosine (m⁶A) methylation represents a dynamic and reversible post-transcriptional modification regulated by m⁶A methyltransferases, m⁶A demethylases, and m⁶A reader proteins. It is recognized as the most prevalent RNA modification in eukaryotic organisms. Recent studies have progressively elucidated the biological roles of m⁶A methylation in livestock and poultry production, highlighting its involvement in regulating critical life processes, including growth and development, reproductive physiology, glucose and lipid metabolism, oxidative stress, and cellular damage. Alterations in factors such as nutrition, environment, and disease within livestock and poultry production can disrupt m⁶A methylation modifications, thereby impacting the physiological metabolic processes of these animals. Nonetheless, nutritional regulation strategies have the potential to restore methylation homeostasis, thereby facilitating the regulation of growth, development, and diseases in livestock and poultry. This article provides a comprehensive review of these topics, offering novel insights and strategies for enhancing growth performance and ensuring the health of livestock and poultry.

Key words: m⁶A methylation modification, methylation homeostasis, nutrients regulation, livestock and poultry

CLC Number:

S852.2

BAI Guangdong, LOU Zekai, WANG Ruiqi, ZHAO Xuan, LI Jiawei, XIA Yaoyao, PANG Jiaman. Advances in m⁶A Methylation Modification and Nutritional Regulation in Livestock and Poultry[J]. Acta Veterinaria et Zootechnica Sinica, 2025, 56(9): 4215-4231.

Figures/Tables 3

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病原性细菌 Pathogenic bacteria	器官/细胞 Organs/cells	m⁶A甲基转移酶/甲基化水平 m⁶A methylase/methylation levels	文献来源 Literature sources
金黄色葡萄球菌 Staphylococcus aureus	牛乳腺上皮细胞	METTL3、METTL14、WTAP、ALKBH5↑	[75]
大肠杆菌 Escherichia coli	牛乳腺上皮细胞	METTL3、METTL14、WTAP、ALKBH5↑	[76]
大肠杆菌F18 Escherichia coli F18(E.coli F18)	IPEC-J2	METTL3↑	[77]
	IPEC-J2	METTL3↑	[78]
	IPEC-J2	WTAP↑	[79]
大肠杆菌K88 Escherichia coli K88(E.coli K88)	IPEC-J2	m⁶A水平↑	[80]
C型产气荚膜梭菌 Clostridium perfringens beta2 toxin(CPB2)	仔猪回肠	METTL3、METTL14、FTO、ALKBH5、YTHDF1↑ WATP、YTHDF2、YTHDF3、YTHDC2↓ m⁶A水平↑	[81]
C型产气荚膜梭菌 Clostridium perfringens beta2 toxin(CPB2)	IPEC-J2	METTL3、ALKBH5、YTHDF3↑ METTL14、WATP、FTO、YTHDC1、YTHDC2↓ m⁶A水平↑	[81]
副猪嗜血杆菌 Haemophilus parasuis(Hps)	猪肺泡巨噬细胞	METTL3、METTL14、WTAP、YTHDF2和FTO↓	[82]

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Advances in m⁶A Methylation Modification and Nutritional Regulation in Livestock and Poultry

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Advances in m⁶A Methylation Modification and Nutritional Regulation in Livestock and Poultry