反刍动物胃肠道葡萄糖感应受体与转运载体的功能特征及相关调控

doi:10.11843/j.issn.0366-6964.2024.11.004

Abstract

Abstract:

The glucose sensing receptor (T1R2/T1R3) in the gastrointestinal tract of ruminants can detect the presence of glucose, transmit sweet signals to the central nervous system, and promote the secretion of gastrointestinal hormones and up-regulate the expression of glucose transporters through gastrointestinal hormones. Glucose transporters mainly consist of SGLT1 and GLUT2. The former one is primarily responsible for transporting glucose into gastrointestinal epithelial cells, while the latter one basically involves in transporting glucose from gastrointestinal epithelial cells into adjacent blood vessels. Glucose sensing receptors and transporters work together to fulfill the glucose absorption process in the gastrointestinal tract. In this paper, the functional characteristics of glucose sensing receptors and transporters in the gastrointestinal tract of ruminants and their relevant regulatory mechanisms were reviewed, in order to provide insights and references for improving the utilization efficiency of glucose in ruminants.

Key words: ruminant gastrointestinal tract, T1R2/T1R3, SGLT1, GLUT2, gastrointestinal hormone

CLC Number:

S852

Quanjun CHEN, Zuo WANG, Fachun WAN, Weijun SHEN. Functional Characteristics and Related Regulation of Glucose Sensing Receptors and Transporters in the Gastrointestinal Tract of Ruminants[J]. Acta Veterinaria et Zootechnica Sinica, 2024, 55(11): 4819-4828.

Figures/Tables 4

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Functional Characteristics and Related Regulation of Glucose Sensing Receptors and Transporters in the Gastrointestinal Tract of Ruminants

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