Abstract: The 13th Five-Year National Key Research and Development Program has established a key project of "Prevention and Control of Major Animal Diseases, Efficient and Safe Husbandry Technology Research and Development" (Animal Project), which supported scientific and technological innovation research in the field of animal epidemic prevention and control, efficient and safe breeding and breeding environment treatment. This project carried out the design of "whole chain design and integrated implementation" according to basic research, key technology research and development and integrated demonstration to solve the important basic theory and technical bottleneck of animal breeding in China. Based on the method of bibliometric, a statistical analysis was conducted of the papers supported mainly by the project to master the research progress and hot spots of the special project in basic research and frontier theory. Moreover, the future key research direction and development trend in the field of animal husbandry and veterinary medicine was discussed in combination with the layout of animal husbandry and veterinary related projects in the 14th Five-Year Plan. The results showed that this special funded papers had achieved breakthrough research in the basic research fields of major animal diseases and zoonotic diseases such as the COVID-19, Zika virus and African Swine Fever Achievements:Agriculture-related universities and scientific research institutes cooperate closely and have made great contributions; International cooperation is not only with the United States and other developed countries, but also closely cooperated with developing countries such as Pakistan and Egypt related to the "Belt and Road" initiative. The probability of publishing high-quality papers which cooperated with scientific research teams in developed countries has increased significantly; Research hotspots mainly focus on epidemiology, pathogen replication and evolution, drug resistance, pathogen and host interaction and network regulation, immune and pathogenic mechanisms, cross-species transmission,etc.The livestock and poultry special project focuses on the research direction of the prevention and control of major livestock and poultry diseases and efficient and safe breeding, and has made important research progress in major basic theories, supporting the research and application demonstration of key core technologies. The 14th Five-Year National Key Research and Development Program will make a comprehensive layout in the field of animal seed industry innovation, prevention and control of animal diseases, purification and eradication, nutrition regulation and efficient breeding, waste resource utilization and green breeding, breeding equipment and intelligent breeding.

Key words: bibliometric, National Key R&D Program, animal husbandry and veterinary medicine, basic research progress, research hot spots, review and analysis