ADP-核糖基化调控精子形成的研究进展

doi:10.11843/j.issn.0366-6964.2022.01.002

Abstract

Abstract: ADP-ribosylation is a kind of post-translational modification of proteins catalyzed by ADP-ribosyl transferases (ARTs). It is divided into poly-ADP-ribosylation and mono-ADP-ribosylation, which plays an important role in regulating many biological events during spermatogenesis, such as assembly of centromere and spindle, DNA damage repair and chromatin condensation. Part of the ARTs gene deletion leads to abnormal spermatogenesis, resulting in reduced semen quality and even male infertility. However, the detailed mechanism of spermatogenesis regulated by ADP-ribosylation is still unclear, and the understand on the role of mono-ADP-ribosylation within it is even less. Therefore, this paper reviews the research progress of ADP-ribosylation in spermatogenesis, hoping to provide new ideas for further revealing the regulatory mechanism of spermatogenesis, and promoting breakthrough in the prevention and control of male reproductive disorders and the treatment of male infertility.

Key words: ADP-ribosylation, spermatogenesis, poly-ADP-ribose polymerases, ecto-ADP-ribosyl transferase

CLC Number:

DUAN Chenying, LI Xin, ZHAO Junjin, LI Ruyi, ZHAO Lingjun, GUO Guanhua, YANG Liguo, HUA Guohua, WANG Dong. Research Progress of ADP-ribosylation in Regulating Spermatogenesis[J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53(1): 11-19.

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Research Progress of ADP-ribosylation in Regulating Spermatogenesis

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